Regulation of Src Family Kinases Involved in T Cell Receptor Signaling by Protein-tyrosine Phosphatase CD148 (original) (raw)

CD148, a receptor-like protein-tyrosine phosphatase, plays contradictory roles in signal transduction within the immune system, exhibiting both inhibitory and activating effects on Src family kinases (SFKs) involved in T cell receptor signaling. Unlike its role in B cells and macrophages, CD148 does not compensate for the absence of CD45 in T cells, which may relate to its expression patterns and the specific SFKs it targets. Data indicate that CD148's influence is context-dependent, suggesting a nuanced understanding of its role in T cell signaling and potential implications for therapeutic strategies targeting immune responses.