A Comparative In-vivo Evaluation of Bioactive Glass Composite (HABG) and Osteogen (HAresorb) ® in The Treatment of Infrabony Defects (original) (raw)
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Biomaterials, 2001
Hydroxyapatite (HA)-based materials are considered to be potentially useful as bone implant materials, particularly those reinforced with glass to improve mechanical strength. However, the precise e!ects of glass-reinforced HA on the growth and functions of bone cells are still unclear. The present study has therefore examined the response of human osteoblast-like cells to HA and HA reinforced with two di!erent proportions of glass, namely 2.5% and 5%.
Biomaterials, 2004
The in vivo evaluation, in New Zealand rabbits, of a SiO 2 -P 2 O 5 -CaO sol-gel glass and a SiO 2 -P 2 O 5 -CaO-MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5 mm in diameter and 4 mm in depth, were filled with (i) sol-gel glass disks, (ii) glass-ceramic disks, or (iii) no material (control group). Each group included 8 mature and 8 immature rabbits. A 4-month radiographic study showed good implant stability without axial deviation of extremities in immature animals and periosteal growth and remodelling around and over the bone defect. After sacrifice, the macroscopic study showed healing of bone defects, with bone coating over the implants. The morphometric study showed a more generous bone formation in animals receiving sol-gel glass or glass-ceramic disks than in control group. Histomorphometric study showed an intimate union of the new-formed bone to the implants. This study allows considering both materials as eligible for bone substitution or repair. Their indications could include cavities filling and the coating of implant surfaces. The minimum degradation of glass-ceramic disks suggests its application in locations of load or transmission forces. As specific indication in growth plate surgery, both materials could be used as material of interposition after bony bridges resection. r
Journal of Biomedical Materials Research, 2001
In vitro and in vivo bioactivity studies were performed to assess the biocompatibility of CaO-P 2 O 5 glassreinforced hydroxyapatite (GR-HA) composites. The ability to form an apatite layer by soaking in simulated body fluid (SBF) was examined and surfaces were characterized using FTIR reflection and thin-film X-ray diffraction analyses. Qualitative histology, histomorphometric measurements, and push-out testing were performed in a rabbit model for characterizing bone/implant bonding. Under the in vitro conditions using SBF, an apatite layer could not be formed on GR-HA composites within 8 weeks. Results of push-out testing showed bonding between the composites and bone, ranging from 130-145 N after 2 weeks of implantation. After the longest implantation period, 16 weeks, the GR-HA composite prepared with the higher content of CaO-P 2 O 5 glass showed the highest bonding force, 606 ± 45 N, compared to 459 ± 30 N for sintered HA. Development of immature bone and modifications in the turnover of a more mature bone on the surface of GR-HA composites were similar to those on sintered HA.
Sintered porous DP-bioactive glass and hydroxyapatite as bone substitute
Biomaterials, 1994
There is extensive experimental and surgical experience with the use of bone tissue to fill defects in the skeleton, to bridge non-union sites, and to pack defects in bone created from cyst curettage. DPbioactive glass with a chemical composition of Na,O 8.4%, SiOp 39.6%, P205 12% and CaO 40% has been reported as an alternative bone substitute of high mechanical strength, good biocompatibility and which has a tight bond with living tissue. The bonding layer between DP-bioactive glass and bone tissue was considered to be formed by dissolution of calcium and phosphate ions from the DPbioactive glass into the surrounding body fluids. The biological hydroxyapatite was suspected to deposit directly onto the bonding layer. In order to confirm the interaction between the DP-bioactive glass and bone tissue, the developed bioactive glass was implanted into rabbit femur condyle for 2-32 weeks. The histological evaluation of DP-bioactive glass as a bone substitute was also investigated in the study. Porous hydroxyapatite bioceramic was used in the control group and the results were compared with those of DP-bioactive glass. The interface between the DP-bioactive glass and bone tissue examined with SEM-EPMA showed that the bioactive glass formed a reaction layer on the surface within 2 weeks after operation and formed a direct bond with natural bone. The elements contained in the bioactive glass apparently interdiffuse with the living bone and biological hydroxyapatite deposited onto the diffusion area, which was proved by EPMA and TEM. After implantation for over 8 weeks, the DP-bioactive glass was gradually biodegraded and absorbed by the living bone. Histological examination using the optical microscope showed that osteocytes grow into the inside of the DP-bioactive glass and the bioactive glass would be expected to be a part of bone.
Clinical oral investigations, 2014
The aim of this systematic review was to assess the efficacy of bioactive glass (BG) in bone regeneration for implant site development procedures. The following specific question was formulated with reference to Population, Intervention, Control, Outcomes (PICO): "In persons that undergo bone regeneration surgeries for implant site development, what histological outcomes does the use of BG yield, alone or in combination with AB, compared to positive or negative controls?". The 1st phase of screening yielded 400 titles and abstracts. A total of 12 studies reporting on the use of bioactive glass were scrutinized for inclusion in the final analysis and 5 studies were selected for qualitative synthesis of the results. Data were divided into two categories: ridge preservation (n = 2) and sinus augmentation (n = 3). Within the limitations of this review, it can be concluded that (1) the combination of BG with AB chips in a 1:1 ratio is an efficacious treatment modality for direc...
Saudi medical journal
To compare the effectiveness of bioactive glass (BG), natural hydroxyapatite (HA), and demineralized freeze-dried bone (DFDB) in bone defects. All animal experiments were conducted in Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey, under the Selcuk University Guidelines for Animal Experimentation, in 2005. Eighteen New Zealand rabbits were used for the experiment. Four cavities were prepared on right and left tibias. The cavities on the right tibia were filled with either BG, HA or DFDB. One cavity was left empty as a control. The cavities on the other tibial bone were grafted with HA(+)BG, HA(+)DFDB, BG(+)DFDB and HA(+)BG(+)DFDB composites. Histological examinations were performed at first, third, and sixth postoperative months. According to histomorphometric findings, the mixture containing HA(+)BG(+)DFDB obtained the best histological results (p<0.05). The composite graft of HA, BG and DFDB is more effective than when used as individual agents.
Materials Science Forum, 2012
The bovine bone and sintetic hydroxyapatite (HA) bioceramics are reference materials to employment as a bone substitute, however, their slow rate of degradation and its low rate of bioactivity index (Ib) are presented as limiting factors for application as bone graft. In contrast, the bioglass is a resorbable and osteoinductive material. the present work objective the development of composites of dispersed bovine bone or sintetic HA in silicate-phosphate bioglass, seeking to obtain a biomaterial with properties suitable for application as bone grafts. The composites were prepared by mixing between the powder components followed by sintering for 1h. Were used HA and bioglass (45S5) with particle size <240μm. The tested proportions of HA/45S5 were 20/80, 30/70 and 40/60 (wt%). The composites characterization was made employing scanning electron microscopy, Infra-Red Spectrometry and hydrolytic resistance test. The test results indicate the potential use of the materials developed f...
Diffusion and Defect Data Pt.B: Solid State Phenomena, 2010
Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts such as hydroxyapatite or ceramics and bioactive glasses are used as osteoconductive materials that serve as scaffold for new bony ingrowth. The purpose of this study was to ascertain the possible regenerative capability of glass reinforced hydroxyapatite (Bonelike ) an osteoconductive synthetic graft in the treatment of human periodontal intrabony angular defects. The material was placed in 2 defects in 2 individual patients and clinical parameters such as probing depth (PD) and clinical attachment level (CAL) have been included. Bone fill was determined using an intra oral periapical radiograph (IOPA) and Autocad Software. After 3 months implantation period, there was an improvement in CAL and reduction in PD along with bone fill was observed.
Clinical Oral Implants Research, 2005
Objective: The purpose of this study was to histologically analyze the influence of bioactive glass and/or a calcium sulfate barrier on bone healing in surgically created defects in rat tibias. Material and methods: Sixty-four rats were divided into 4 groups: C (control), CS (calcium sulfate), BG (bioactive glass), and BG/CS (bioactive glass/calcium sulfate). A surgical defect was created in the tibia of each animal. In Group CS, a calcium sulfate barrier was placed to cover the defect. In Group BG the defect was filled with bioactive glass. In Group BG/CS, it was filled with bioactive glass and protected by a barrier of calcium sulfate. Animals were sacrificed at 10 or 30 days post-operative. The formation of new bone in the cortical area of the defect was evaluated histomorphometrically.
A glass-reinforced hydroxyapatite (HA) composite (Bonelike®) was developed for bone grafting. This biomaterial is composed of a modified HA matrix with α- and β-tricalcium phosphate secondary phases, resulting in higher solubility than single HA type of materials. Several in vitro and in vivo studies demonstrated that Bonelike® has a highly bioactive behavior, which was also confirmed by employing granular forms of this biomaterial in orthopedics and dental applications. However, a fast consolidation vehicle was needed to promote the fixation of Bonelike® granules if applied in larger defects or in unstable sites. Surgical-grade calcium sulfate (CS), which is widely recognized as a well-tolerated and inexpensive bone graft material, was the chosen vehicle to improve the handling characteristics of Bonelike® as it can be used in the form of a powder that is mixed with a liquid to form a paste that sets in situ. After application in non-critical monocortical defects in sheep, histological, and scanning electron microscopy evaluations demonstrated that Bonelike® associated to CS functioned as a very satisfactory scaffold for bone regeneration as it achieved synchronization of the ingrowing bone with biomaterial resorption and subsequent preservation of the bone graft initial volume. Therefore, our results indicate that CS is an effective vehicle for Bonelike® granules as it facilitates their application and does not interfere with their proven highly osteoconductive properties. In the opposite way, the incorporation of Bonelike® improves the bone regeneration capabilities of CS.