Unicentric Castleman’s disease located between the aorta and inferior vena cava: A case report (original) (raw)
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Retroperitoneal unicentric Castleman's disease with multiple lymph node involvement
BMJ case reports, 2011
A 78-year-old woman with B-symptoms was referred for a left adrenal incidentaloma of 5 cm. Imaging revealed features compatible with adrenal cancer. The authors excluded excess production of catecholamines or adrenal steroids. The tumour was removed by en bloc radical left retroperitonectomy with adrenalectomy, nephrectomy, interaortocaval lymphadenectomy and splenectomy. Histology demonstrated periadrenal hyaline vascular Castleman's disease with local infiltration and 14 positive lymph nodes. The lymphoid infiltrate spilled into the adjacent renal cortex. HHV8 was negative. The Ki67 proliferative index was 30-40% in germinal centres. There was no syn- or metachronous disease on extended imaging including fluorodeoxyglucose positron emission tomography-CT and narrow follow-up at 3 years. This is a rare case of unicentric hyaline vascular Castleman's disease with documented locoregional lymph node involvement. The case exemplifies the transition from unifocal unicentric dise...
A Case of Retroperitoneal Castleman's Disease and an Update on the Latest Evidence
Case reports in surgery, 2014
Castleman's disease is a benign lymphoproliferative condition with three distinct histological subtypes. Clinically it presents in either a unicentric or multicentric manner and can affect various anatomic regions, the mediastinum being the most frequent location. We herein present a rare case of unifocal retroperitoneal mass proved to be hyaline vascular Castleman's disease. We perform a review of the current literature pertaining to such lesions, focusing on the management of the various clinical and histological variants of the disease. Surgical excision is the treatment of choice for unifocal Castleman's disease.
UNICENTRIC CASTLEMAN DISEASE PRESENTING AS A LARGE RETROPERITONEAL MASS-A CASE REPORT
Castleman disease (CD) described by castleman as a large,benign,asymptomatic mass involving mediastinal lymph nodes.The causes of CD are mostly unknown.As patients with CD can have markedly different presentation and clinical courses,with some lesions requiring innovative approaches to therapy, the major unifying feature is the histologic appearance. It may be unicentric or multicentric, hyaline-vascular variant or plasma cell variant. Unicentric variant mostly present as a isolated lymph node mass ,often mediastinal or cervical. We present a case of unicentriccastleman disease (hyaline vascular variant) presenting as a large retroperitoneal mass.
A rare case of retroperitoneal castleman disease
IP innovative publication pvt. ltd, 2019
Castleman disease is a rare hyperplastic disorder that can affect any group of lymph nodes. Clinically and radiologically, it can mimic a malignancy and can only be diagnosed by histopathological examination. Castleman disease should be considered as one of the differential diagnosis for a patient presenting with a retroperitoneal mass. Complete surgical excision is usually curative; a preoperative diagnosis by biopsy can avoid extensive surgery for this condition. In this case report, we present a 40 year old female with a retroperitoneal mass, which was clinically suspected to be a malignancy. Complete surgical excision was done and histopathological examination of the mass revealed a unicentric Hyaline vascular type of Castleman disease.
Life Science Journal
Castleman’s disease (CD) is a rare benign disorder characterized by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. CD comprises at least two distinct diseases (unicentric (localized) and multicentric) with very different prognoses. Surgery remains the main treatment for resectable unicentric CD. The two principal histologic subtypes of CD are hyaline-vascular, plasma cell variants and a mixed variant. We report two cases of unicentric Castleman’s disease (UCD) treated at our institute that mimic retroperitoneal neoplasm and cured by surgical excision. We review the literature on the management of this rare entity and concentrate more on UCD.
World Journal of Surgical Oncology, 2014
Background Castleman’s disease is a rare and poorly understood disease entity that may resemble more common conditions and represents a clinical challenge to the treating surgeon. Case presentation In this report, we describe a case of a 61-year-old Caucasian woman with a symptomatic retroperitoneal mass. The specimen obtained from her resection contained a protuberant encapsulated mass, exhibiting microscopic features consistent with localized, unicentric Castleman’s disease. These characteristics included architectural features and immunohistochemical findings consistent with the hyaline vascular variant of Castleman’s disease. Conclusion We report a very rare case of a retroperitoneal hyaline vascular type of Castleman’s disease. We discuss the diagnostic dilemma Castleman’s disease may present to the surgeon, with an emphasis on multidisciplinary management of these patients. We also review current data on pathogenesis, treatment and outcomes.
A Case Report on Isolated Retroperitoneal Castleman's Disease
Castleman disease (CD) is an uncommon lymph proliferative disorder and is especially rare in the retro peritoneum or per renal area. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. After removal of the lesion, local CD has a good prognosis. It is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue related to the chronic human herpes virus 8
Hyaline vascular Castleman's disease: a case report and brief review of the literature
The Netherlands journal of medicine, 2002
We describe a 27-year-old female with a mesenterial localisation of the hyaline vascular type of Castleman's disease. A review of the literature is given with emphasis on the different pathogenesis of the subtypes. The hyaline vascular type is a disorder of stromal cells, which can be complicated by the development of soft tissue sarcomas. The plasma cell type is a plasma cell disorder with elevated levels of interleukin-6 (IL-6). In the multicentric type, infection with human herpes virus-8 (HHV-8) plays an important role in the pathogenesis. The development of Kaposi's sarcoma and some lymphomas are related to the presence of HHV-8. As the different subtypes have a different pathogenesis they should be regarded as distinct diseases.