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A novel oxidative stress marker in acute myocardial infarction; thiol/disulphide homeostasis
The American Journal of Emergency Medicine, 2015
Background: The aim of this study was to investigate a novel oxidative stress marker (thiol/ disulphide homeostasis) in patients with acute myocardial infarction (AMI), and compare the results with healthy controls for the first time in literature. Methods: A total of 450 participants including 300 patients with AMI, and 150 healthy individuals were included in the study. Left ventricular ejection fraction, body mass index, peak troponin I levels, triglyceride, total cholesterol, LDL, HDL, native thiol, total thiol, and disulphide, as well as disulphide/native thiol and disulphide/total thiol ratios were compared between the groups. Results: There were significant differences between AMI patients and the controls for LVEF, and troponin, HDL, native thiol, total thiol, and disulphide levels, as well as disulphide/ native thiol and disulphide/ total thiol ratios (p<0.05). Stepwise logistic regression model indicated that HDL (OR=0.923: p<0.001) and disulphide levels (OR=0.548: p<0.001), and disulphide / total thiol ratio (OR=0.356: p<0.001) were significantly and independently related to AMI. The cutoff value of disulphide / total thiol ratio percentage on admission to predict AMI in all population was 4.3, with a sensitivity of 70%, and a specificity of 69%. Conclusion: Thiol/ disulphide homeostasis may be used as a novel oxidative stress marker in patients with AMI because it is readily available, easily calculated and relatively cheap. Further studies are needed to confirm the pathophysiological role of thiol/ disulphide homeostasis in AMI.
Kardiologia polska, 2018
Cardiovascular diseases are still one of the leading causes of death in industrialised countries, and oxidative stress plays an important role in the pathogenesis of acute coronary syndromes (ACS). The dynamic thiol/disulphide homeostasis plays an important role in maintaining the oxidant-antioxidant balance. We aimed to demonstrate the relationship between dynamic thiol/disulphide homeostasis parameters and non-ST elevation ACS (NSTE-ACS). Patients with NSTE-ACS (n = 210) and a control group (n = 185) were included in the study. The GRACE risk score and the development of major adverse cardiovascular event (MACE) were used to evaluate the prognosis. Native thiol, total thiol, disulphide/native thiol, disulphide/total thiol, and native thiol/total thiol levels were found to be lower in the NSTE-ACS group (p < 0.001). There was a statistically significant difference between native and total thiol levels in the GRACE risk score subgroups (p < 0.001). There was a correlation betw...
Online Journal of Health and Allied …, 2010
Background: Reactive oxygen species have been implicated in the pathogenesis of ischemic and reperfusion injury. In the current work we have measured malondialdehyde (MDA), total thiols, total CK, CK-MB and AST in ECG proven acute myocardial infarction (AMI) patients immediately after admission and 24 hours after administration of thrombolytic agent streptokinase, and in healthy controls. Methods: Blood samples from 44 AMI patients and 25 age and sex matched healthy controls were obtained and analyzed for MDA, total thiols using spectrophotometric methods and cardiac enzymes CK, CK-MB and AST using automated analyzer. Results: We have found significant increase in MDA, CPK, CK-MB, AST (p< 0.001) and significant decrease in total thiols (p<0.001) in AMI patients after thrombolytic therapy compared to values at admission, and healthy controls. MDA correlated negatively with total thiols (r = -0.333, p<0.05) and positively with CK-MB (r = 0.491, p<0.01) in AMI patients after thrombolytic therapy. Conclusions: Reperfusion following thrombolytic therapy increases reactive oxygen species with concomitant decrease in antioxidant total thiols.
Journal of Medical Biochemistry
Background: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI. Methods: The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography. Results: Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI...
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2018
The aim of this study was to investigate whether low thiol levels are associated with peri-procedural factors during primary percutaneous coronary intervention (pPCI) upon admission with ST-segment elevation myocardial infarction (STEMI), and the prognostic value at 6-month follow-up. A total of 241 consecutive acute STEMI patients who underwent pPCI and a control group of 67 individuals with a normal coronary angiography were enrolled in the study. While age, contrast-induced nephropathy, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), stent length, and creatinine were related to native thiol, NT-proBNP, contrast-induced nephropathy, and creatinine were related to total thiol. NT-proBNP was also related to the disulphide level. The left ventricular ejection fraction (LVEF) and the levels of native thiol, total thiol, low-density lipoprotein, and serum albumin were found to be independent predictors of major adverse cardiovascular events (MACEs) during 6 months of fo...
Study of hyponatremia as prognostic factor In acute ST elevation myocardial infarction (STEMI
Hyponatremia has been shown to be a predictor of cardiovascular mortality among patients with heart failure and the same mechanism of neurohormonal activation is also acting in cases of STEMI 1 Hence we aimed to investigate importance of hyponatremia in acute STEMI regarding prognosis and short term survival. 100 consecutive patients presenting with acute STEMI admitted to Rajendra institute of medical science (RIMS) Ranchi, Jharkhand from October 2016 to September 2017 were studied. Qualifying patients underwent detailed history and clinical examination. Plasma sodium concentrations were obtained on admission and at 24, 48 and 72 hours thereafter along with other relevant investigations. Males made up 81% of patients who presented with hyponatremia on admission and 77% of patients who developed hyponatremia within 72 hours. Patients who presented with or developed hyponatremia more often were smokers(81%) and had diabetes(44%), anterior infarction(72%) and higher killip class, lower ejection fraction(40.36 ±6.14) compared to patients with normal sodium levels. The odd's ratio for 30-day mortality was found to be high in the hyponatremic groups compared to normal group. We also found a significant linear relationship between severity of hyponatremia and mortality. Multivariate analysis was performed which identified hyponatremia on admission or early development of hyponatremia as a significant independent predictor of 30 day mortality.
Study of pro-oxidant status in acute myocardial infarction
Asian Journal of Medical Sciences, 2018
Background: Apart from several well documented risk factors; oxidative stress may play an important role in the pathogenesis of myocardial infarction. Our study has been designed to investigate the pro-oxidant status in AMI patients who have no previous history of diabetes, hypertension and habit of smoking.Aims and Objectives: To measure the level of serum thiobarbituric acid reactive substances(TBARS) to assess the extent of oxidative damage in recently diagnosed cases of AMI and to look for any correlation between this stress marker and some of the lipid profile markers.Materials and Methods: A cross sectional study was conducted in a tertiary care hospital with 50 non-diabetic, non-hypertensive, non-smoker AMI patients of either sex as Cases and 50 age and sex matched healthy Controls. The biochemical parameters were measured by validated techniques.Results: Level of serum TBARS (4.78 ± 1.06 nmol/ml) has significantly increased…