Cow's milk protein allergy. A multi-centre study: clinical and epidemiological aspects (original) (raw)
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Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2016
Cow's milk protein allergy (CMPA) is the most frequently encountered form of food allergy in pediatric patients and occurs secondary to cow's milk proteins (CMP) ingestion. The aim of this study is to define the profile of children suffering from CMPA and to describe the associated pathological findings. The authors performed a retrospective case-control study on 160 infants that presented with CMPA symptoms at "Sf. Maria" Emergency Clinical Hospital for Children, Iassy, Romania, between January 2013 and January 2015. Fifty-five infants were diagnosed with CMPA (Group 1 - cases group) and 105 had no proven allergy (Group 2 - control group). Mean age of patients, gender distribution and prevalence of premature birth registered no statistically significant difference between the two groups. The prevalence of familial history of allergy was higher in case of patients with CMPA (36.36% versus 20% in control group). The delay between the introduction of CMP into aliment...
Symptoms of Cow Milk Protein Allergy in Children – a Retrospective Study
Romanian Journal of Pediatrics, 2015
Introduction. Recent meta-analyses of population-based studies show considerable heterogeneity in the prevalence of perceived and confirmed allergic reactions, as well as sensitization to cow milk ingestion. Adverse reactions to cow milk ingestion have different prevalence patterns in different age groups. There is increasing public concern about the true prevalence and a possible increase of food allergies over time, particularly among parents, child care and school staff, health care providers, regulators and food producers. Materials and methods. We performed a retrospective study of children admitted in IOMC hospital in Bucharest between January 2011 to May 2013. The primary aim of this study was to establish and compare the prevalence of confirmed allergic reactions to food in young children from IOMC hospital to known symptoms established by different researches. Results. 312 patients were evaluated with IgE panel blood test, 64 were IgE positive to cow milk protein fraction. ...
Role of results of immunological investigations in diagnosing cow's milk protein allergy
2021
Cow’s milk is one of the main causes of food allergy in young and pre-school children. Symptoms of cow’s milk protein allergy can differ, depending on affected target organ. Thus, compiling anamnesis, it is necessary to conduct complex assessment of complaints and a child’s general condition. Active investigation is being conducted to improve diagnostics of cow’s milk protein allergy in children, particularly with involvement of modern laboratory capabilities. The aim of the work was to optimize diagnostics of cow’s milk protein allergy considering results of immunological investigations in children over three years of age. Materials and methods. Establishment of diagnosis included record of allergological anamnesis, elimination diet, conduction of elimination and provocation food test, determination of specific IgE, conduction of skin allergy testing and oral provocation test in adequate conditions. Optimal tactics of treatment is determined based on the results of conducted invest...
Assessment of IgE-Mediated and Non-IgE-Mediated Cow’s Milk Protein Allergy in Children
ARS Medica Tomitana, 2019
Cow’s milk protein allergy (CMPA) is the most common food allergy found in children under 3 years of age. In most cases, it occurs in infancy. Early diagnosis and appropriate treatment can decrease the risk of impaired growth. In our study, we evaluated 40 children, with ages between 1 month and 3 years, diagnosed with IgE-mediated or non-IgE-mediated CMPA, from january to december 2017, in the Department of Pediatrics of the Clinical Emergency County Hospital of Constanta. The inclusion criteria consisted of: age, natural or artificial feeding, specific IgE levels, CoMiSS score, and clinical manifestations. The Cow’s Milk-related-Symptom-Score (CoMiSS) was developed as a screening and diagnostic tool for CMPA prediction, and can guide pediatricians and primary care physicians to make an early diagnostic, as it can be easily missed. We observed a higher number of cases of CMPA registered among children who were artificially fed (57,5%), followed by those with mixed nutrition (25%), ...