Preparation, Physical Characterization and Antibacterial Activity of Ni (II), Cu (II), Co (II), Cd (II), Zn (II) and Cr (III) Schiff Base Complex Compounds (original) (raw)
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Synthesis, Characterisation and Antimicrobial Studies of Schiff Base and Its Metal Complexes
International Research Journal of Pure and Applied Chemistry, 2020
Four metal complexes of Co(II), Pb(II), Ni(II) and Fe(II) ions with a Schiff base derived from (3methoxy-4-hydroxy-benzaldehyde with leucine) have been synthesized and characterized using several physical techniques, in particular; molar conductance measurements, colour, melting point, infrared and electronic spectra. The molar conductance values reveal a non-electrolytic nature. The infrared spectral data display the coordination behaviour of the Schiff base toward Co(ll) ,pb(ll) ,Ni(ll) and Fe(ll) ions. The electronic absorption spectra of the Schiff base and its complexes show π→π* (phenyl ring) and, n→π* (HC=N) and the expected geometrical structure for the prepared complexes. The Schiff base and its complexes were tested for antimicrobial activity against grampositive bacteria; Staphylococcus aurous; E. Coli and Klebsiella, in addition Rizopus as fungal. The effect of the Schiff base leucine complex on bacteria was recorded only against Staphylococcus aureus and Escherichia col...
The Pharma Innovation Journal, 2016
The new bidentate Schiff base ligand namely [(E)-N 1-(4-methoxy benzylidene) benzene-1, 2-diamine] was prepared from condensation of 4-Methoxy benzaldehyde with O-Phenylene diamine at 1:1 molar ratio in ethanol as a solvent in presence of drops of 48% HBr. The structure of ligand (L) was characterized by, FT-IR, U.V-Vis., 1 H-, 13 C-NMR spectrophotometer, melting point and elemental microanalysis C.H.N. Metal complexes of the ligand (L) in general molecular formula [M(L)3], where M= Mn(II), Co(II), Ni(II),Cu(II) and Hg(II); L=(C14H14N2O) in ratio (1:3)(Metal:Ligand) were synthesized and characterized by Atomic absorption, FT-IR, U.V-Vis. spectra, molar conductivity, chloride content, melting point and magnetic susceptibility from the above data the geometrical formula was octahedral for all complexes. And in vitro tests for antibacterial activity showed that most of the prepared compounds display activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeruginosa).
Medical Laboratory Journal, 2017
Background and objectives: Synthesis and characterization of several metal complexes (metal ions: Co 2+ , Ti 4+ and Ce 3+) of macroacyclic Schiff base ligand have been reported. The Schiff base ligand is prepared from the condensation reaction of 1, 4-di-(4fluoro-2-aminophenoxy) butane with salicylaldehyde in ethanol. In addition, antibacterial activity of metal ions, Schiff base ligand and their complexes have been investigated. Recent studies show that many Schiff base complexes have antibacterial activity against Grampositive and Gram-negative bacteria. Therefore, we aimed to synthesize new Schiff base complexes and evaluate their antibacterial activity against a number of Gram-positive and Gram-negative bacteria. Methods: Schiff base ligand and their complexes were characterized by mass spectrometry, FTIR, 1 H-NMR and 13 C-NMR spectroscopy. The invitro antibacterial activity of the Schiff base ligand, metal ions and their complexes were evaluated against some Grampositive and Gram-negative bacteria by disk diffusion method and determining minimum inhibitory concentration. Results: In this study, the Schiff base complexes had good antibacterial activity, but the Schiff base ligand and metal ions did not show any antibacterial effect. In some cases, the antibacterial effect of the complexes was higher than that of the standard antibiotics tetracycline and gentamycin. The titanium complex showed the highest antibacterial activity in both methods. This complex created the largest growth inhibition zone (diameter: 100mm) against Staphylococcus aureus, and had the lowest minimum inhibitory concentration against Bacillus subtilis (6.75 mg/mL). Conclusion: The compounds synthesized in our study have strong antibacterial activity.
The aim of the present work is to synthesize some Schiff base complexes of metal ion and to evaluate their antimicrobial activities. Novel Schiff base ligand derived from 2-hydroxybenzophenone with S-benzyldithiocarbazate and its metal complexes with Ni (II), Cu (II), Zn (II) and Cd (II) have been synthesized and evaluated for their antibacterial activities by disc diffusion method and antifungal activities by PDA medium. The complexes have been characterized by conductance, magnetic, IR and electronic spectroscopic techniques.
Metal complexes of Schiff base: Preparation, characterization and antibacterial activity
A total of five new metal complex derivatives of 2N-salicylidene-5-(p-nitro phenyl)-1,3,4thiadiazole, HL with the metal ions Vo(II), Co(II), Rh(III), Pd(II) and Au(III) have been successfully prepared in alcoholic medium. The complexes obtained are characterized quantitatively and qualitatively by using micro elemental analysis, FTIR spectroscopy, UV-Vis spectroscopy, mass spectroscopy, 1 H & 13 C NMR, magnetic susceptibility and conductivity measurements. From the spectral study, all the complexes obtained as monomeric structure and the metals center moieties are four-coordinated with square planar geometry except VO(II) and Co complexes which existed as a square pyramidal and tetrahedral geometry respectively. The preliminary in vitro antibacterial screening activity revealed that complexes 1-5 showed moderate activity against tested bacterial strains and slightly higher compared to the ligand, HL.
Synthesis and Antibacterial Study of Some Schiff Bases Complexes
Modern Organic Chemistry Research, 2017
Novel Schiff bases (E)-N-(4-chlorobenzylidene)-2-(2,4-dichlorophenyl) acetohydrazide and (E)-2-(2,4-dichlorophenyl)-N'-((1-methoxynaphthalen-2-yl)methylene) acetohydrazide were synthesized and further used for the synthesis of metal complexes. All these synthesized Schiff bases and metal complexes were characterized and screened for antimicrobial activity against bacteria Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis.
American Journal of Applied Chemistry, 2023
The Schiff base; 2-hydroxybenzalidene-1-naphthylamine and its Mn(II) and Ni(II) complexes were synthesized and characterized using, conductivity measurement, magnetic susceptibility, elemental analyses, melting point/decomposition temperature, electronic spectral analyses, infrared spectral analysis and solubility test. The Schiff base and its metal complexes were tested for antimicrobial activity. The molar conductance values range (6.52-23.1 Ω-1 cm 2 mol-1) revealed non-electrolytic nature of the complexes. The magnetic susceptibility values; 5.91 BM indicated Mn(II) complex as paramagnetic while-Ve indicated Ni(II) complex as diamagnetic. The elemental analyses results revealed slight differences between calculated and observed percentages of values of C, H, and N, which is in line with the proposed structures of the synthesized compounds. The high decomposition temperature range (201-223°C) indicated good stability of the complexes. The infrared spectra analysis results suggested that the Schiff base behave as bidentate ligand coordinates to metal ion via azomethine nitrogen and phenolic oxygen. The antimicrobial activity of the Schiff base and its metal complexes were carried out using agar well diffusion method against two bacteria strains; (Salmonella typhi and streptococcus pneumoniae) and two fungal isolates; (Aspergillus fumigatus and Rhizopus species). The results revealed that the Schiff base and its metal complexes exhibited moderate antimicrobial activity as compared with the standard drugs; (Gentamycin and Nystatin).
Benha Journal of Applied Sciences, 2022
Finding novel active compounds to solve the problem of microbial resistance of antibiotic is a matter of urgency. That's why several drugs were produced from many precursors. Schiff bases are a good base for synthesis several antimicrobial compounds. This work investigates biological activities as cytotoxicity and antimicrobial properties of some Schiff base compounds which synthesized by coupling reaction between two aromatic amines namely: aminoantipyrine, and 4-aminophenol by two aldehydes namely: vanillin and gluteraldehyde. Metal complexes of the obtained four Schiff bases were prepared throughout reaction with copper and ferric ions. FTIR, atomic absorption spectroscopy and 1 H-NMR measurements. microbial evaluation of Schiff bases and metal complexes was tested against various microorganisms including: gram +ve and gram-ve bacterial strains utilizing the diameter of inhibition zone, and minimum inhibitory concentration procedures. Showing that the cytotoxic effect of metal complexes is more than the ligand form. Furthermore, Ferric metal complexes exhibited significant inhibition than the copper complexes, which was attributed to the ability of oxidation-reduction tendency of Fe 3+ ions than Cu 2+. The gram genera of the bacterial strains played a significant role on their resistivity towards the tested antimicrobial compounds, own to the nature of their cellular membranes.