Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens (original) (raw)

Norovirus: Targets and tools in antiviral drug discovery

Dirk Jochmans

Biochemical Pharmacology, 2014

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Discovery of a Novel Class of Norovirus Inhibitors with High Barrier of Resistance

Eloise Mastrangelo

Pharmaceuticals

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Computational studies on the interaction of ABO-active saccharides with the norovirus VA387 capsid protein can explain experimental binding data

Göran Larson, Per-Georg Nyholm

Journal of Computer-Aided Molecular Design, 2010

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An in silico virtual screening study for the design of norovirus inhibitors: fragment-based molecular docking and binding free energy calculations

Magnus Lundborg

Carbohydrate Research, 2013

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Identification of compelling inhibitors of human norovirus 3CL protease to combat gastroenteritis: A structure-based virtual screening and molecular dynamics study

Nawal Helmi

Frontiers in Chemistry

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Human Noroviruses' Fondness for Histo-Blood Group Antigens

Bishal Singh

Journal of Virology, 2014

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Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity

Frederick Neill

Nature Communications

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Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease

Gerald Lushington

European journal of medicinal chemistry, 2018

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High-Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus 1 Capsid Protein Protruding Domain

John Rubin

Journal of Virology, 2010

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Targeting Norovirus Infection—Multivalent Entry Inhibitor Design Based on NMR Experiments Dedicated to Professor Heinz Rüterjans on the occasion of his 75th birthday

Francisco Parra

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Unveiling of Pyrimidindinones as Potential Anti-Norovirus Agents—A Pharmacoinformatic-Based Approach

Oluwakemi Ebenezer

Molecules, 2022

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Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease

Gerald Lushington

Journal of Medicinal Chemistry, 2020

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Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors

Gerald Lushington

European Journal of Medicinal Chemistry, 2016

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Crystal Structure of Inhibitor-Bound GII.4 Sydney 2012 Norovirus 3C-Like Protease

Kurt Krause

Viruses

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In Silico Screening and Molecular Dynamics Simulation Studies in the Identification of Natural Compound Inhibitors Targeting the Human Norovirus RdRp Protein to Fight Gastroenteritis

Farah Anjum

International Journal of Molecular Sciences

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In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors

Jingxu Guo

Journal of Structural Biology: X, 2020

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Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives

Lijuan Yuan

Future Virology, 2015

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GII.4 Human Norovirus: Surveying the Antigenic Landscape

Ralph Baric

Viruses

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Characterization of a novel conformational GII.4 norovirus epitope: Implications in norovirus-host interactions

Javier Buesa

Journal of Virology, 2016

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Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments

Julie Guiard

Chemistry - A European Journal, 2011

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More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules

David J Rowlands

Nature Structural & Molecular Biology, 2014

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Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

Makoto Yamazaki

Journal of Virology, 2012

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The P Domain of Norovirus Capsid Protein Forms a Subviral Particle That Binds to Histo-Blood Group Antigen Receptors

Ming Tan

Journal of Virology, 2005

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Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Gabriela Alvarado

Nature Communications, 2021

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Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as Determined by STD NMR Spectroscopy

Francisco Parra

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Structure of human enterovirus 71 in complex with a capsid-binding inhibitor

Moh Yap

2013

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Structural analysis of a designed inhibitor complexed with the hemagglutinin-neuraminidase of Newcastle disease virus

Mark Von Itzstein

Glycoconjugate Journal, 2006

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Noroviral P particle: Structure, function and applications in virus–host interaction

Intan Less

Virology, 2008

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Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C

Naemi Welter

PLOS Biology

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Particle conformation regulates antibody access to a conserved GII.4 norovirus blockade epitope

Taylor Jones, Eric Donaldson

Journal of virology, 2014

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