Clinical Outcomes and Cost of Outpatient Community-Based Treatment for Rituximab Refractory Non-Hodgkins Lymphoma (NHL) Patients (original) (raw)

Blood, 2004

Abstract

Introduction: We examined treatment patterns, clinical outcomes, and cost of treatment for NHL patients refractory to rituximab (no response or duration of less than 6 months) in US community outpatient hematology/oncology practices. Methods: Patients with an NHL diagnosis receiving antineoplastic treatment after failing rituximab were selected from a de-identified electronic medical record (EMR) database installed at 14 practices in 8 states. Any systemic chemo/immunotherapy regimen starting within 6 months of the end of a rituximab-containing treatment course was eligible for analysis, except rituximab monotherapy which could not be distinguished from maintenance treatment. Treatment-free interval (TFI) was calculated from last day of the post-rituximab regimen until start of the next antineoplastic regimen. Survival was calculated from day 1 of the regimen. Both were censored at the last active visit date if no event was recorded in the EMR at database cut-off (3/31/04). Hematolo...

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