Immunization against Paratuberculosis - Current perspectives (original) (raw)

2014, International Journal of Livestock Research

Johne's disease is chronic progressive enteritis of domestic and wild ruminants caused by Mycobacterium avium subsp. paratuberculosis. Organism is very sturdy in environment and young animals are more susceptible to the disease from infected carriers via contaminated milk, feed and colostrums. For the dairy industry, economic losses from Johne's disease are primarily due to premature disposal of animals and reduced milk production. Therefore, a vaccine that prevents animals from becoming infected would be an ideal goal and there is no proper test for the diagnosis, it is prudent to control the disease by immunization. There are mainly three types of vaccine, which are killed, modified live and subunit vaccine. Current vaccines could reduce the severity of infections but they are all failing to give sterile and long lasting immunity. So it is imperative that experimental studies should be conducted to produce an ideal vaccine candidate against MAP.

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