Current Biomedical Applications of 3D Printing and Additive Manufacturing (original) (raw)
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Additive Manufacturing in Biomedical Application
IJIRIS:: AM Publications,India, 2024
Additive Manufacturing (AM), commonly known as 3D printing, has revolutionized the field of biomedical applications by offering innovative solutions for personalized and complex structures. This technology enables the fabrication of patient-specific implants, prosthetics, and tissues with enhanced precision and customization. The versatility of additive manufacturing allows the incorporation of biocompatible materials, fostering the development of implants tailored to individual anatomical requirements. Additionally, the rapid prototyping capabilities of 3D printing facilitate the creation of intricate models for surgical planning and education. The use of bioinks and biomaterials in additive manufacturing has paved the way for the fabrication of functional tissues and organs, advancing the prospects of regenerative medicine. Furthermore, the scalability and cost-effectiveness of 3D printing in the biomedical field hold significant promise for widespread adoption and accessibility. In conclusion, additive manufacturing stands as a transformative force in biomedical applications, offering unparalleled opportunities for personalized healthcare and advancing the frontiers of medical technology.
Additive Manufacturing in Medical Applications: A Comprehensive Review
IJRAME PUBLICATIONS, 2024
Additive Manufacturing (AM), or 3D printing, is transforming the medical field by enabling the creation of highly customized and complex medical devices and implants. This review examines AM's applications in prosthetics, orthotics, surgical instruments, and bioprinting. AM enhances patient-specific treatments by providing better-fitting prosthetics, tailored surgical instruments, and customized implants, leading to improved clinical outcomes. Additionally, bioprinting offers promising advancements in regenerative medicine and tissue engineering. Despite its benefits, AM faces challenges such as material limitations, regulatory hurdles, and technical constraints. Future directions include advances in bioprinting, integration with digital health technologies, and expansion of material options. As researchers and clinicians collaborate to overcome these challenges, AM is poised to play an increasingly crucial role in healthcare, enhancing patient care and advancing medical science.
Three-dimensional (3-D) cell printing, which can accurately deposit cells, biomaterial scaffolds and growth factors in precisely defined spatial patterns to form biomimetic tissue structures, has emerged as a powerful enabling technology to create live tissue and organ structures for drug discovery and tissue engineering applications. Unlike traditional 3-D printing that uses metals, plastics and polymers as the printing materials, cell printing has to be compatible with living cells and biological matrix. It is also required that the printing process preserves the biological functions of the cells and extracellular matrix, and to mimic the cell-matrix architectures and mechanical properties of the native tissues. Therefore, there are significant challenges in order to translate the technologies of traditional 3-D printing to cell printing, and ultimately achieve functional outcomes in the printed tissues. So it is essential to develop new technologies specially designed for cell printing and in-depth basic research in the bioprinted tissues, such as developing novel biomaterials specifically for cell printing applications, understanding the complex cell-matrix remodeling for the desired mechanical properties and functional outcomes, establishing proper vascular perfusion in bioprinted tissues, etc. In recent years, many exciting research progresses have been made in the 3-D cell printing technology and its application in engineering live tissue constructs. This review paper summarized the current development in 3-D cell printing technologies; focus on the outcomes of the live printed tissues and their potential applications in drug discovery and regenerative medicine. Current challenges and limitations are highlighted, and future directions of 3-D cell printing technology are also discussed.
Application of 3D printing for engineering and bio-medicals: recent trends and development
https://doi.org/10.1007/s12008-022-01145-z, 2022
Manufacturing, industrial design, decorations, footwear, design, architecture, engineering and construction, car, aviation, dentistry and clinical enterprises, education, geographic data frameworks, structural designing, and a variety of other fields have all seen 3D printing as beneficial. In every area of application, additive manufacturing has been seen as a speedy and cost-effective solution. The applications of 3D printing are rapidly developing, and it is quickly becoming a genuinely remarkable breakthrough worth paying close attention to. In this article, we'll look at how 3D printing works, as well as existing and prospective applications in engineering and biomedicine. Scarcity of organ transplant recipients is a serious clinical concern all around the globe. Older procedures had a number of drawbacks, including complications, future injuries, and a scarcity of donors. Tissue engineering scaffolds, cell healing, and direct tissue printing are all potential for overcoming these limitations using 3D printing technology. This article provides an overview of 3D printing advancements, materials, applications, advantages, limitations, challenges, financial considerations, and 3D metal printing applications. An introduction to biomedical materials, a discussion of material-related 3D printing challenges, and a discussion of the future potential uses for medical applications has been discussed in present article.
Medical Applications of 3D Printing
2018
Three-dimensional printing (3DP) is an entirely novel method of manufacture with its applications only limited by the imagination. The mainstay of 3DP utilisation practically to date has been in the field of engineering, largely for the purpose of generating model prototypes. However, the potential of 3DP has increasingly been recognised in areas of commercial manufacture in medicine due to its capacity to produce materials and devices that can equal, if not surpass, the benefits of traditional consumer goods. The opportunities for future uses are innumerable ranging from tissue engineering, the on-demand fabrication of medical devices and advanced applications in other fields with the same pressing need for medical personalisation. The 3D printing arena is ultimately exciting and endless in opportunities with the FDA encouraging the development of science and risk based approaches. This chapter will discuss the existing and future medical applications of 3DP and its potential to re...
3D Printing: Challenges and Its Prospect in Futuristic Tissue Engineering Applications
2020
Additive manufacturing in the healthcare sector has promisingly paved its way since the failure of implants, and tissue analogs resulted from the improper fabrication strategies of conventional manufacturing procedures. High energy source additive manufacturing strategies are optimum in regard to the appropriate mimicking of the shape of the host tissue or organ. However, there are subtle issues which critically impact the final outcome of the whole process, i.e., imaging of the patients’ tissue, reconstruction of the model, fabrication, and surgery. In many of the high-energy laser sintering facilities, the choice of the materials is very shallow. Moreover, cell-laden constructs are highly questionable to be used within these processes as it requires very low temperature (~37 °C) and low stress in the environment for the cells to be functional. Due to these drawbacks of other procedures, extrusion-based procedures have become popularly explored and utilized, leading the current add...
Recent Developments in 3D Bio-Printing and Its Biomedical Applications
Pharmaceutics
The fast-developing field of 3D bio-printing has been extensively used to improve the usability and performance of scaffolds filled with cells. Over the last few decades, a variety of tissues and organs including skin, blood vessels, and hearts, etc., have all been produced in large quantities via 3D bio-printing. These tissues and organs are not only able to serve as building blocks for the ultimate goal of repair and regeneration, but they can also be utilized as in vitro models for pharmacokinetics, drug screening, and other purposes. To further 3D-printing uses in tissue engineering, research on novel, suitable biomaterials with quick cross-linking capabilities is a prerequisite. A wider variety of acceptable 3D-printed materials are still needed, as well as better printing resolution (particularly at the nanoscale range), speed, and biomaterial compatibility. The aim of this study is to provide expertise in the most prevalent and new biomaterials used in 3D bio-printing as well...
Advances in 3D Printing for Tissue Engineering
Materials, 2021
Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering.
Toward Biomimetic Scaffolds for Tissue Engineering: 3D Printing Techniques in Regenerative Medicine
Frontiers in Bioengineering and Biotechnology, 2020
Three-dimensional (3D) printing technology allows fabricating complex and precise structures by stacking materials layer by layer. The fabrication method has a strong potential in the regenerative medicine field to produce customizable and defect-fillable scaffolds for tissue regeneration. Plus, biocompatible materials, bioactive molecules, and cells can be printed together or separately to enhance scaffolds, which can save patients who suffer from shortage of transplantable organs. There are various 3D printing techniques that depend on the types of materials, or inks, used. Here, different types of organs (bone, cartilage, heart valve, liver, and skin) that are aided by 3D printed scaffolds and printing methods that are applied in the biomedical fields are reviewed.
3D printed tissue and organ using additive manufacturing: An overview
Clinical Epidemiology and Global Health
Background: Research papers on Additive Manufacturing (AM)/3D printing in tissue/organ printing are studied to understand its capability for tissue and organ printing with and new advancement in the medical field. Aim of the research: To study and discuss the advantages and limitations of AM when used for printing of customised scaffold, tissue and organ, which are a challenge to the medical field. Materials and methods: This literature-based study understands the creation of innovation in the medical field and its different areas to address upcoming challenges. Thus, relevant research papers from the Scopus database are identified and purposefully analysed. Result: Studied the main components of additive manufacturing as required for tissue and organ printing and process used to create tissue/organ by using this technology. We have further identified different materials based requirements for tissue and organ printing and how this technology can fulfil this requirement to save the life of the patient. Finally, this paper identifies eight significant advancements of AM in the medical field with a brief description and limitations when additive manufacturing is used for tissue and organ printing. Conclusion: In the current scenario, tissue engineering and cell therapy employ an innovative approach to reduce the mortality rate. However, the main challenge for this is customisation, which is somewhat taken up by AM technologies. This technology has already addressed different challenges in the medical field. For tissue and organ printing, this technique seems better as compared to 2D conventional cell technique. With the help of scanned data, 3D printing allows us to create intricate internal structures. Thus, it can be used to develop bone tissues, which are required for clinical applications towards the treatment of bone defects. It also plays an outstanding role in cardiac masses, heart disease, physiology, electrophysiology, tested for diagnosis and better treatment of valvular heart disease. Doctors and surgeon easily understand the aortic valve of the patient. It improves post-surgery, blood flow and helps proper selection of devices including stents. AM is to take up the challenge for the development of artificial bone with biomechanical properties as similar to bone. It uses the material in the form of powder, wire and ceramic. It has promising applications to print liver tissue and liver cell and fulfils the requirement of customisation in different fields.