Synthesis and Antimycobacterial Activity of a Novel Series of Isonicotinylhydrazide Derivatives (original) (raw)
2009, Archiv der Pharmazie
A series of eight N'-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 µg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.
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