Phytochemical and pharmacological activities of Solanum surattense Burm. f.–A review (original) (raw)
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Ethno medicinal, phytochemical and pharmacological aspects of solanum incanum (lin.)
Solanum incanum is used in Africa and other parts of world as a folklore remedy for various ailments that include; sore throat, angina, stomach ache, ear inflammation, snake bites, wounds, liver disorders, skin ailments (ringworm), warts, inflammatory conditions, painful periods and fever. Phytochemical studies of this herb indicate that it contains substances such as steroidal alkaloids, glyco-alkaloids, antioxidants (flavonoids and chlorogenics), saponins and even carcinogenic substances. The herbal extract posses antinociceptive, antipyretic, anti-spasmolytic, orexic, anorexic, hypoglycemic, antimicrobial, anti-schistosomal, anti-fungal, and anti-cancer activity. The herb is therefore likely to be a major source of novel, affordable and effective therapeutic substances against myriad ailments afflicting people in the world. This review explores the phyto-pharmacological effects of the S. incanum and compiles vital information that may assist researchers on what is known about this herb and gaps for further investigation.
Journal of applied and natural sciences, 2024
Turkey berry, also known as Solanum torvum Swartz, is native to Africa, Asia and South America. This tropical plant of the fami-ly Solanaceae has versatile uses in both food and medicine in tropical and subtropical countries. It has been employed in tradi-tional medicine all over the world. Chemical composition of this fruit, its pharmacological properties as ascertained through sci-entific investigations and its clinical applications are discussed. S. torvum contains numerous important metabolites such as saponins steroids and flavonoids, which function as antioxidants, antifungal, antidiabetic, anticancer, antiulcer, antianxiety and immunomodulators. Various notable roles in ethnomedicinal uses and approaches as a traditional medicinal herb. These have been found in large amounts and have various functions, including antioxidant properties against cardiovascular diseases and immune-modulating activities. Notably leaves extracts, fruits etc. have beneficial therapeutic traits. For a long time now, “Solanum torvum” has been used to treat numerous conditions such as fever, wounds, etc. Research backs up these traditional uses by pointing out the plant’s blood pressure management, kidney protection nature, and immune-boosting capabilities. The review summarizes the importance of ethnobotany, its chemical composition, and the scientifically proven pharmacological ac-tivities of S. torvum.
The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review
Natural Products and Bioprospecting
Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using "Solanum" and the species' names as search terms ("all fields"). Keywords Solanum • Solanaceae • Phytochemistry • Steroidal saponins and alkaloids • Ethnopharmacology Abbreviations ABTS 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) CC 50 Cytotoxic concentration of the extracts to cause death to 50% of host's viable cells CDDP cis-Diamminedichloroplatinum DPPH 2,2-Diphenyl-1-picrylhydrazyl EC50 Half maximal effective concentration GABA Neurotransmitter gamma-aminobutyric acid HBV Hepatitis B Virus HSV-1 Herpes simplex virus type 1 IC50 Minimum inhibition concentration for inhibiting 50% of the pathogen LD50 Dose required to kill half the members of a tested population after test duration MIC Minimum inhibitory concentration MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide SAG Superoxide anion generation
Phytochemical screening and evaluation of analgesic activity of Solanum surattense
The leaves of the medicinal plant Solanum surattense (Family-Solancceae) were extracted in 95% ethanol to evaluate centrally acting analgesic potential at two different doses, (250 and 500 mg/kg body weight). Three different test methodologies; hot plate test, acetic acid induced writhing test and formalin test were employed to assess the analgesic activity. A significant analgesic activity of the extract was observed in mice; 39.34% and 60.47% (P<0.05 and P<0.001) protection against thermal-induced pain, 33.98% and 49.59% (P<0.001), protection against acetic acid-induced writhing and 40.00% and 67.80% (P<0.05 and P<0.001) protection against formalin induced pain. The crude extract of the plant was found to have significant (p<0.05) analgesic activity at the dose of 250 and 500 mg/kg that suggests the presence of active principles in the extract responsible for analgesic activity.
An updated ethnobotany, phytochemical and pharmacological potential of Solanum indicum L
Journal of Drug Delivery and Therapeutics, 2022
Solanum indicum L. (Family Solanaceae), also known as poison berry in English, is a thorny, heavily branched perennial under shrub that can grow up to 1 metre in height and reach heights of up to 1 metre in height. This wonderful medicinal plant is extensively used in folk and traditional Indian systems of medicine to treat toxic affections, skin problems, ulcers, difficulties breathing, stomach aches, coughing, and dyspepsia, among other conditions. It is native to India and can be found throughout the country, primarily in warmer climates up to an elevation of 1500 metres. It is a well-known Indian medicinal plant that has been utilised extensively in the Ayurvedic system of medicine of treatment for many years in various ailments. It is a key component of the dasamoola group of plants' composition. Solasodine, Solasonine, Solamargine, Solanidine, and Solanine are some of the active steroidal alkaloids/glycoalkaloids found in S. indicum. The presence of various phytoconstituen...
Pharmacognostical studies on Solanum surrattence Burm f. Root
Journal of Pharmacognosy and Phytochemistry, 2014
Objective: To investigate macroscopic, microscopic, qualitative phytochemical and pharmacognostic parameters of Kantakari (Solanum surrattense Burm f.) root, a plant species which is well mentioned in Ayurvedic classics and an important constituent of Ayurvedic combination forms i.e. laghupanchmula and dashmula. The plant is also used in preparation of variety of indigenous medicine. Methods: Macroscopic, microscopic, qualitative phytochemical analysis, physiochemical analysis, extractive values in ethanol and water of the root were done. Results: Macroscopic and microscopic study showed distinct morphological characteristics in the root. Physiochemical analysis of root powder revealed, moisture content 2.1%, total ash 10.4%, acid-insolubal ash 2.7%, sulphated ash 11.33%, alcohol soluble extractive7.5%, water soluble extractive 13.6%. Alkaloids, carbohydrates, proteins, resins, saponins, steroid, tannin, starch, glycosides, flavonoids and triterpenoids were present in root extracts....
International Journal of Scientific & Technology Research, 2016
Pharmacological properties of medicinal plants and various natural products of plant origin lie in the chemical constituents they contain. Thus, in most cases, the principal aim of phytochemical analysis of plants and natural products is to detect, isolate, characterize and identify these chemical substances. This paper reviews scientific works carried out on the ethnomedicinal uses, phytochemistry and pharmacological properties of Solanum incanum L. It was understood that various parts of this plant were traditionally used to treat various types of ailments. A study of literature reveals some notable pharmacological activities of the plant such as antimicrobial activity, antimalarial activity, the antinociceptive effects, antioxidative property, immunological effects and many more medicinal values. Various phytochemical analyses carried out on the plant also revealed the presence of vast array of phytocompounds which were medicinally important. There for this paper was reviewed and...
Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds
Journal of Tropical Medicine
Several medicinal plants have the potential to be a promising alternative pharmacological therapy for a variety of human illnesses. Many insects, including mosquitoes, are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Medicinal plants continue to provide a large library of phytochemicals, which can be used to replace chemically synthesized insecticides, and utilization of herbal product-based insecticides is one of the best and safest alternatives for mosquito control. Identifying new effective phyto-derived insecticides is important to counter increasing insect resistance to synthetic compounds and provide a safer environment. Solanum genus (Solanaceae family or nightshades) comprises more than 2500 species, which are widely used as food and traditional medicine. All research publications on insecticidal properties of Solanaceae plants and their phytoconstituents against mosq...
Solanum indicum L. (Fam. Solanaceae) commonly known as poison berry in English is a prickly, much branched perennial under shrub, nearly upto 1m high, mostly found throughout India in warmer parts upto an elevation of 1500 m. This important medicinal plant is widely used in folk and traditional Indian systems of medicine for poisonous affections, skin diseases, ulcers difficult breathing, abdominal pain, cough and dyspepsia. In Ayurveda and Siddha. It is an important ingredient of dasamoola group of plants. The review attempts to highlight various available literature with respect to the therapeutic uses, enthno-medicinal uses, pharmacognostic studies, chemical constitutes and various reported pharmacological activities. Some steroidal alkaloids/glycoalkaloids such as Solasodine, Solasonine, Solamargine, Solanidine and Solanine were reported by various investigators. Pharmacognostic studies revealed the presence black powdery depositions of sandy crystals, throughout the root, sclerieds in the cortical region, phloem fibres towards the periphery and uni to biseriate medullary rays in xylem and phloem as the diagnostic characters of root of S. indicum. It is reported to have hepatoprotective, anthelmintic, antioxident and antimicrobial activity.