Clinical and Immunological Markers of Pulmonary Impairment among People with HIV(PWH) in India (original) (raw)

Open Forum Infectious Diseases

Background Despite anti-retroviral therapy, chronic lung diseases remain an important source of morbidity and mortality in people with HIV (PWH). We sought to identify clinical and immunological markers of pulmonary impairment among PWH in India. Methods 210 adult PWH receiving antiretroviral therapy (ART) were prospectively evaluated for three years. Plasma concentrations of interleukin (IL)-6, IL-10, TNF-a, D-dimer, C-reactive protein, soluble (s)CD14 and sCD163 were measured at enrolment. We used multi-variable linear and logistic regression to measure the association of baseline and time-varying clinical and immunological variables with spirometry defined chronic obstructive pulmonary disease (COPD), restrictive spirometry pattern (RSP), preserved ratio impaired spirometry (PRISm), forced expiratory volume in 1st second (FEV1) and forced vital capacity (FVC) during the third year of follow-up. Results After adjusting confounders, females were 7 times more likely to have RSP (95%...