P1613Elastic properties of the ascending aorta in patients with a bicuspid aortic valve and isolated severe aortic stenosis versus regurgitation (original) (raw)

2018, European Heart Journal

Congenital heart disease diagnostic aspects 315 vanced hemodynamic parameter. The previous study demonstrated greater ventricular kinetic energy is necessary to generate flow in the pulmonary circulations in patients with repaired tetralogy of Fallot (rTOF). However, there is no clear mechanism regarding the energy transfer between myocardium and intraventricular flow. Purpose: The purpose of this study is to assess the MRI derived kinetic energy transfer in the right ventricle (RV) of rTOF patients. Methods: The study consisted of 26 rTOF patients (age: 22.2±3.2 y/o; male/female: 17/9) and 15 age-matched normal subjects (age: 22.0±1.2 y/o; male/female: 8/7) without known cardiovascular disease. They all underwent MRI with tissue phase mapping (TPM) and 4D flow. TPM was performed in longitudinal (z), radial (r), and circumferential (Ø) directions. Kinetic energy (KE) derived from 4D flow was computed. MRI derived parameters were compared between two groups. Results: rTOF group presented higher PR fraction, higher RV stroke volume index, and increased RV end-systolic and end-diastolic volume index than normal group (all p<0.001). There was no statistically difference of RV ejection fraction (p>0.05) in both groups. In systolic phase of RV, rTOF group exhibited significantly higher KEr (1.7±0.7 mJ vs 1.3±0.5 mJ, p<0.05), lower KEØ (0.4±0.2 mJ vs 1.3±0.6 mJ, p<0.001), and KEz (1.5±1.0 mJ vs 5.0±2.7 mJ, p<0.001) than normal group. In diastolic phase of RV, TOF group presented higher KEr (2.3±1.1 mJ vs. 1.2±0.4 mJ, p<0.001) and lower KEz (1.6±1.3 mJ vs. 5.8±2.2 mJ, p<0.001) than normal group. rTOF group demonstrated lower summation of KE than normal group during both systole (p<0.001) and diastole (p<0.001) of RV myocardium. As for RV intraventricular flow, only higher summation of diastolic KE were observed in rTOF group than in normal group (p<0.001). rTOF group had shorter basal time to peak of KE gradient than normal subjects (p<0.01). Conclusions: Our study quantified the difference of RV myocardial and intraventricular flow KE in rTOF patients with preserved RV function. Further studies are required to elucidate the effect of the different kinetic energy transfer on the cardiac function in rTOF patients.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact