Helicobacter pylori Infection in a Pediatric Population from Romania: Risk Factors, Clinical and Endoscopic Features and Treatment Compliance (original) (raw)

Prevalence of Helicobacter Pylori Among Children in a Training and Research Hospital Clinic in Istanbul and Comparison with Updated Sydney Classification Criteria

Northern Clinics of Istanbul, 2020

H elicobacter pylori is a gram-negative microorganism that is commonly seen worldwide. Robin Warren and Barry Marshall discovered it as the causative agent of gastritis and peptic ulcer in 1982 [1]. More than 50% of the world's population is infected with H. pylori [2]. It is also more common in developing countries and the prevalence of H. pylori is approximately 90% in these countries [3]. H. pylori-associated infection can be either clinically silent or non-specific. Specific signs or symptoms are including esophagitis, gastroesophageal reflux, and various motility disorders. Older children with peptic complaints may have symptoms more than younger children, and diagnosis of H. pylori infection is more difficult in early childhood. Childhood, early adult years, living in developing or poor countries have an apparent risk for infection [4]. Although H. pylori-associated infection in our country has limited data for the epidemiology, in Turkey, the prevalence of H. pylori infection in children has been ABSTRACT OBJECTIVE: Helicobacter pylori (H. pylori) is a gram-negative bacterium and one of the reasons for gastritis, peptic and duodenal ulcers. It is a crucial public health problem for both children and adults, especially in developing countries. This study aims to investigate the prevalence of Helicobacter pylori positivity in children and to compare with updated Sydney classification criteria. METHODS: This study was conducted from January 2015 to June 2017. This study included 885 children aged 0-17 year(s). Endoscopic biopsies were evaluated for the diagnosis of infection due to H. pylori. RESULTS: The findings showed that 418 (47.2%) of 885 children were positive for H. pylori, and this positivity had a significantly increasing correlation with the presence of chronic inflammation, neutrophilic activity, lymphoid aggregates, and follicles. Erythematous pangastritis and antral nodularity on endoscopic findings had a correlation with H. pylori positivity. CONCLUSION: In this hospital-based study, the findings suggest that H. pylori infection is a problem for children and more extensive studies are needed to determine the prevalence of H. pylori positivity among children.

Decrease in prevalence of Helicobacter pylori infection during a 10-year period in Brazilian children

Arquivos de Gastroenterologia, 2008

BACKGROUND: Decreasing prevalence of H pylori infection has been reported in some countries. AIM: To evaluate the prevalence of Helicobacter pylori infection in a 10-year period in children submitted to upper digestive endoscopy. METHODS: It was a retrospective observational study. The records of 1,165 endoscopies performed during a 10-year period in a public hospital of the City of São Paulo, SP, Brazil, in patients up to 18-year-old. Only the first endoscopy was considered. Helicobacter pylori infection was defined by the rapid urease test, performed with one fragment of antral mucosa. Chi-square for trend has been estimated to compare Helicobacter pylori prevalence across the period. RESULTS: The main indication for endoscopy was epigastric pain (47.4%). There were 392 patients with H pylori infection (33.6%), 12.8% being infants, 19.4% toddlers, 28.8% schoolchildren and 46.3% adolescents. Prevalence was 60.47% in the first year of the study and 30.43% in the last. Among the less...

Change of Helicobacter pylori prevalence in a decade among children undergoing endoscopy

The Turkish journal of pediatrics, 2016

Our aim was to investigate the trend of H. pylori infection among children during the last decade by a retrospective analysis. Reports of children in whom esophago-gastroduodenoscopy was performed at our institution during two periods 2002-2003 and 2012-2013 were seperated into Group I and Group II, respectively. Pathology reports were investigated for gastritis, atrophy and H. pylori presence. A total of 380 children, 131 in Group I and 249 in Goup II were recruited in the study. H. pylori postivity was found to be higher in Group I (% 48.1 and % 23.1, respectively, p < 0.001). Gastritis and atrophy were associated with H. pylori and both were more prevalent in Group I (p < 0.001). Our study demonstrates that H. pylori prevalence is decreasing in a pediatric population undergoing EGD in Ankara. This is the most recent study regarding pediatric H. pylori prevalence change in Turkey that we know of.

Epidemiology, Diagnosis, and Risk Factors of Helicobacter pylori Infection in Children

Euroasian Journal of Hepato-Gastroenterology, 2017

ABSTRACTH. pyloriinfection is a global public health problem associated with some gastrointestinal diseases in children, especially in developing countries, since prevalence ofH. pyloriis low in the developed world. Both noninvasive (stool antigen test, urea breath test, and blood test) and invasive (histology, rapid urease test, and microbiological culture) tests have been utilized to detectH. pyloriinfection. However, a single test is not reliable enough and does not provide accurate enough data to determineH. pyloriinfection among children. Risk factors ofH. pyloriinfection in children were related to ethnicities, household properties, geographic location, living conditions, water sources, type of housing, presence/absence of sewage systems, and garbage collection within the living environment. These risk factors were usually associated with the socioeconomic status of the family. This review article aims to determine the gaps in the knowledge of the epidemiology, risk factors, a...

Significant Reduction in the Prevalence of Helicobacter Pylori Infection in Albanian Children

2016

Background: In developing countries, Helicobacter pylori infection is very common and begins in the very early childhood. Aim: To determine the prevalence of H pylori infection in Albanian children aged 8-10 years comparing with the data of the study in 1994 and to identify factors associated with H pylori infection. Methods: The prevalence of H pylori infection was studied in 308 asymptomatic children between of 8 and 10 years from mixed urban and rural areas. Of two different districts of Albania. H pylori status was evaluated by stool antigen test (SAT). Urea-breath test were used in 1994 study. Demographic information, socio-economic feature, and living and hygiene condition, such as type of the house, number of person/children living in the house, practices related to water use and toilet facility were evaluated by a detailed questionnaire completed by the teachers with the cooperation of parent of each children. Results: The overall prevalence of H pylori infection was 58%. C...

Helicobacter pylori and gastrointestinal symptoms in school children in Russia

Journal of Gastroenterology and Hepatology, 2004

Background and Aims: Helicobacter pylori is considered to be the major cause of chronic gastritis and duodenal ulcer disease recurrence in childhood. However, the association between H. pylori and recurrent abdominal pain (RAP) syndrome is still controversial. Therefore, the spectrum of clinical variants of gastrointestinal symptoms associated with H. pylori-positive status was studied in consecutive symptomatic children who were undergoing diagnostic endoscopy. Methods: A consecutive series of 225 school children from the Ural area of Russia (mean age 11.1 + 1.4 years, age range 7-15 years) who presented with RAP were investigated using esophagogastroduodenoscopy, including three antral biopsies for histology and polymerase chain reaction. Helicobacter pylori immunoglobulin G antibodies were found using a second-generation enzyme immunoassay. Information about the clinical symptoms was collected using a special questionnaire. Results: The authors found a high incidence of H. pylori infection (80%) and peptic ulcers (16%) in 225 school children from the Ural area of Russia who were referred for upper gastrointestinal (UGI) endoscopy for chronic abdominal pain. Of the overall 225 symptomatic children who underwent endoscopy, 182 (80,8%) were found to be H. pylori-positive. Duodenal ulcers were detected in 36 H. pyloripositive children. A family history of peptic ulcers was significantly more frequent in the children infected with H. pylori (P < 0.001). Symptom score and duration of symptoms were similar, but nighttime pain (P < 0.0001) and fasting pain relieved by food (P < 0.001) were more frequent in the H. pyloripositive children as compared with the H. pylori-negative children. Conclusions: The present results provide further evidence for a significant association between H. pylori and some patterns of gastrointestinal symptoms in children who underwent UGI endoscopy in order to exclude an organic cause of severe chronic gastrointestinal disorders.

Potential Complications of Helicobacter pylori Infection in Children of a Non-Urban Community

Archives of Pediatric Infectious Diseases, 2015

Background: Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections worldwide and has several adverse consequences particularly on health of pediatric patients. Objectives: The current study addressed various clinical presentations associated with H. pylori infections among children of a rural community. Materials and Methods: In this case-control study, the number of cases (H. pylori-positive) were 120 (52.5% boys and 47.5% girls) and the control group (H. pylori-negative) were 100 cases aged 7-12 years old (Mean 9.9 ± 3 years). H. pylori infection was defined by positive results for H. pylori stool antigen test and serum IgG or urea breath test. All pediatric participants were assessed for weight, height, sideropenic anemia and gastrointestinal symptoms. Results: The results showed that recurrent abdominal pain, recurrent vomiting and anorexia were 81 (67.5%), 24 (20%) and 15 (12.5%), respectively in H. pylori-infected patients, compared to 28 (28%), 8 (8%) and 4 (4%) in control group. Weight and height were 20.4 ± 1 kg and 128.1 ± 1 cm in case group compared to 25.6 ± 1.7 kg and 133.8 ± 2 cm in control group. Sideropenic anemia was 36.7% in patients compared to 15% in control. Conclusions: In conclusion, the study findings revealed that pediatric H. pylori infection is associated with recurrent abdominal pain, anorexia and recurrent vomiting, also adversely affects the growth of children in various modalities; in particular weight, height and progressive incidence of sideropenic anemia.

Natural History and Symptomatology of Helicobacter pylori in Childhood and Factors Determining the Epidemiology of Infection

Journal of Pediatric Gastroenterology and Nutrition, 2006

Background: High seroprevalence rates for Helicobacter pylori have been reported in developing countries, yet few studies exist determining the pattern of change in the epidemiology of H. pylori infection in children. The knowledge of acquisition and loss rates of H. pylori and the relevance to the sociodemographic properties and the symptomatology of infection may provide clues for lifestyle changes that might protect children from infection, and also, it may provide rationale for eradication, screening, and protection policies. Our aim was to conduct a prospective study to elucidate the outcome, rate of acquisition, and loss of H. pylori infection in a population of healthy children.