Wars Do not Kill Only with Guns: A Case of Rabies in a Syrian Refugee (original) (raw)

2018, Mediterranean Journal of Infection Microbes and Antimicrobials

Despite developments in medicine, rabies remains nearly 100% mortal [1,2]. In this paper, we present a fatal case of rabies in a Syrian refugee who had been bitten by a dog in Syria and developed rabies in Turkey. A 28-year-old Syrian man admitted to the Emergency Service with a 2-day history of shortness of breath, difficulty in swallowing and muscle weakness. He had been living in Turkey as a refugee for three years but had visited Syria three times in the previous 12 months. He had a history of a dog bite on the posterior of his left foot, two months previously in Syria. The patient had killed the dog after being bitten. He had no history of rabies vaccination at the time of the dog bite. However, he had received antibacterial prophylaxis. His neurological examination was also normal except lack of Achilles deep tendon reflex. His laboratory findings were as follows; leukocytes: 5970/mm 3 neutrophils: 71.3% and C-reactive protein: 0.12 mg/dL. Cranial computed tomography and contrast-enhanced cranial magnetic resonance imaging were found to be normal. After 17 hours in the emergency department, the patient attacked the nurses and doctors on duty, who were also immunized with rabies vaccine after the event. Afterwards, the patient was sedated and intubated. Lumbar puncture revealed no leukocyte, protein level of 35 mg/dL and glucose level of 145 mg/dL. Cerebrospinal fluid (CSF) culture and multiplex polymerase chain reaction (PCR) for common viral agents did not show any pathogen. His specimens for rabies (serum, CSF, saliva, nuchal skin biopsy) were sent to Etlik Veterinary Control Central Research Institute, Rabies Diagnosis Laboratory in Ankara for rabies virus diagnostic evaluation. Viral RNA was positive in saliva sample with a RNA concentration of 229.2 ng/µL and with a crossing point value of 29.70 by real time PCR. Viral RNA was negative in CSF with a RNA concentration of 0.1 ng/µL and in nuchal skin biopsy with a RNA concentration of 1.7 ng/µL by real time PCR. No antibody titer was detected in the serum by fluorescent antibody virus neutralization test. Hypotension and pneumonia were detected on his examination after 12 hours and meropenem and linezolid were started. The patient was transferred to the isolation room in the intensive care unit. However, despite all efforts, he had cardiac arrest at the end of 48-h follow-up. After death, the brain sample was