Phenotypic and molecular genetic profiles of fluconazole and voriconazole sensitive versus resistant candida spp (original) (raw)

Frequent use of azole group of antifungal drugs for prophylaxis and treatment of Candida infections has contributed to the emergence of resistant strains, especially among non-albicans Candida species. The present study was done to identify genetic variations and changes in cellular morphology among non-albicans Candida isolates resistant to fluconazole and voriconazole. Candida isolates obtained from two local hospitals were identified using CHROMagar CandidaTM and commercial biochemical test kits. Among these 41 isolates, the most predominant species was C. alis (n=10), followed by C. albicans (n=7), C. parapsilosis (n=6), C. krusei (n=6), C. rugosa (n=6), C. dubliniensis (n=3) and C. glabrata (n=3). Resistance breakpoints of fluconazole and voriconazole were determined for these 41 Candida isolates using the E-test method. C. glabrata and C. parapsilosis strains that were susceptible and resistant towards the two azoles were selected for further studies as they were commonly isol...

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