αvβ5 Integrin Receptors at the Apical Surface of the RPE: One Receptor, Two Functions (original) (raw)

The research investigates the role of αvβ5 integrin receptors located on the apical surface of retinal pigment epithelial (RPE) cells in regulating two critical functions: phagocytosis of photoreceptor outer segments (POS) and maintaining retinal adhesion. It finds that the lack of αvβ5 leads to impaired rhythm in POS phagocytosis and reduced retinal adhesion, with both processes operating independently and following distinct diurnal rhythms. The study explores possible ligands for αvβ5 integrin functions and highlights the implications for age-related retinal diseases linked to dysfunctional RPE phagocytosis.