Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors (original) (raw)

This review discusses the potential of analyzing circulating tumor DNA (ctDNA) from cerebrospinal fluid (CSF) as a minimally invasive method for detecting and characterizing primary and metastatic brain tumors. It highlights the limitations of traditional tissue acquisition methods and emphasizes the emerging role of liquid biopsies in providing critical genomic data without the need for invasive procedures. The review also addresses the implications of ctDNA profiling for precision medicine, particularly in the context of brain tumor management.