The study of hepatitis B surface antigen and anti-HCV in HIV infected patients (original) (raw)
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Coinfection of hepatitis B and hepatitis C virus in HIV-infected patients in south India
World Journal of Gastroenterology, 2007
AIM: To screen for the co-infection of hepatitis B (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected patients in southern India. METHODS: Five hundred consecutive HIV infected patients were screened for Hepatitis B Virus (HBsAg and HBV-DNA) and Hepatitis C virus (anti-HCV and HCV-RNA) using commercially available ELISA kits; HBsAg, HBeAg/ anti-HBe (Biorad laboratories, USA) and anti-HCV (Murex Diagnostics, UK). The HBV-DNA PCR was performed to detect the surface antigen region (pre S-S). HCV-RNA was detected by RT-PCR for the detection of the constant 5' putative non-coding region of HCV. RESULTS: HBV co-infection was detected in 45/500 (9%) patients and HCV co-infection in 11/500 (2.2%) subjects. Among the 45 co-infected patients only 40 patients could be studied, where the detection rates of HBe was 55% (22/40), antiHBe was 45% (18/40) and HBV-DNA was 56% (23/40). Among 11 HCV co-infected subjects, 6 (54.5%) were anti-HCV and HCV RNA positive, while 3 (27.2%) were positive for anti-HCV alone and 2 (18%) were positive for HCV RNA alone. CONCLUSION: Since the principal routes for HIV transmission are similar to that followed by the hepatotropic viruses, as a consequence, infections with HBV and HCV are expected in HIV infected patients. Therefore, it would be advisable to screen for these viruses in all the HIV infected individuals and their sexual partners at the earliest.
HBV and HCV Co infection in HIV Patients in Northeren India
2021
1. Abstract 1.1. Introduction: Hepatitis B and hepatitis C virus (HBV and HCV) which have potential not only for causing both acute and chronic hepatitis but also are responsible for coinfection in HIV-infected patients. 1.2. Aims and Objectives: The aim of present study was to determine the co-infection of hepatitis B and C virus in serum samples of HIV positive individuals attending HIV clinic in Tertiary care centre of Northern India. 1.3. Material and Methods: The present study was conducted to determine the Co-infection of hepatitis B and C virus in stored serum samples of HIV-positive individuals attending the HIV Clinic at Post Graduate Institute of Medical Sciences in North India. A total of 3311 serum samples of HIV confirmed patients, who were coming on daily basis in HIV Clinic for consultation and treatment were used for the detection of HBV and HCV infection. 1.4. Observations: HBV Co-infection was seen in 65 patients (1.96%) was found to be comparable to HCV Co-infection which was seen in 67 patients (2.02%) amongst the HIV seropositive. The maximum number of HBV & HCV Co-infected patients were seen in 20-40 yrs of age group. 1.5. Results: HBV and HCV Co-infection was found to be1.96% & 2.02% respectively in HIV-positive individuals which is surprisingly less in comparison to seen in normal population in Haryana which is hotspot both for hepatitis B & C.
Virology Journal, 2009
Background: HIV, HBVand HCV is major public health concerns. Because of shared routes of transmission, HIV-HCV coinfection and HIV-HBV coinfection are common. HIV-positive individuals are at risk of coinfection with HBV and HCV infections. The prevalence rates of coinfection with HBV and HCV in HIV-patients have been variable worldwide depending on the geographic regions, and the type of exposure. Aim: This study aimed to examine HBV and HCV coinfection serologically and determine the shared and significant factors in the coinfection of HIV-positive patients. Methods: This descriptive, cross-sectional study was carried out on 391 HIV-positive patients including 358 males and 33 females in Lorestan province, west Iran, to survey coinfection with HBsAg and anti-HCV. The retrospective demographic data of the subjects was collected and the patients' serums were analyzed by ELISA kits including HBsAg and anti-HCV. The collected data was analyzed with SPSS software (15) and Chi-square. Fisher's exact test with 5% error intervals was used to measure the correlation of variables and infection rates. Results: The results of the study indicated that the prevalence of coinfection in HIV-positive patients with hepatitis viruses was 94.4% (370 in 391), out of whom 57 (14.5%) cases were HBsAg positive, 282 (72%) cases were anti-HCV positive, and 31 (7.9%) cases were both HBsAg and anti-HCV positive. Conclusion: There was a significant correlation between coinfection with HCV and HBV and/or both among HIV-positive patients depending on different variables including sex, age, occupation, marital status, exposure to risk factors.(p < 0.001).
The Indian journal of medical research, 2013
Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. We undertook this study to evaluate the presence of HBV and HCV in HIV infected individuals attending a tertiary care centre in southern India. A total of 120 cases with HIV infection and 120 healthy adult control subjects were included in the study. Samples were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies by enzyme linked immunosorbent assay (ELISA) method. HBsAg and anti-HCV positive serum samples were further tested for the presence of hepatitis B e antigen (HBeAg), anti-HBe antibodies, HBV-DNA and HCV-RNA. The most common mode of transmission was sexual promiscuity (79%), followed by spouse positivity (15%) and history of blood transfusion (6%). HBsAg and anti-HCV were positive in 18 (15%) and 10 (8.3%) HIV infected patients; the corresponding figures in healthy controls being 2 (1....
2017
With HBV carrier rate of 4% and approximate carrier pool of 40 million, India belongs to region of intermediate endemicity. 6,7 Antibodies against HCV are present in 1-1.5% of Indian population. 8 The Northeastern State of Manipur, bordering the countries considered to be the Golden Triangle of drug trafficking (Myanmar, Laos and Thailand), has a high population of people who inject drugs (PWID). 9 Manipur ABSTRACT Background: Viral hepatitis is a serious public health problem affecting billions of people globally. The hepatitis B virus (HBV) and hepatitis C virus (HCV) are blood borne pathogens, frequently causing deaths among general and various high risk populations. This study was carried out with the aim to determine the seroprevalence of HBV and HCV in people who inject drugs (PWID) and other risk groups. Methods: A cross-sectional study carried out in the Dept. of Microbiology, RIMS, Imphal from October 2014 to September 2016. 103 high risk individuals, including PWID, spouse of high risk people, unprotected sex with female sex worker (FSW), multiple partners (MP), men having sex with men (MSM) and needle prick injuries were included in this study. Serum samples were tested using enzyme linked immunosorbent assay (ELISA). Results: Out of 103 cases, 87.4% were males and 12.6% females. PWID comprised of 49.5%. Seroprevalence of HBV was 17.4%, anti HBc IgG 16.5% and anti HBc IgM 0.9%. Seroprevalence of HCV was 41.7%, anti HCV IgG 39.8% and anti HCV IgM 1.9%. The rate of HBV and HCV coinfection was 9.7%. Among the PWID seroprevalence of HBV and HCV was 17.6% and 64.7% respectively. Conclusions: This study determines the current status of acute and chronic infection with HBV and HCV in high risk populations. Anti HBc IgG & IgM and anti HCV IgG and IgM are sensitive epidemiological markers to determine the burden of the disease.
SEROPREVALENCE OF HIV, HBV & HCV IN HIGH RISK GROUPS
Aim: The present study is to know the seroprevalence of HIV, HBV, HCV in "high risk groups” i.e STD patients, hemophiliacs and patients undergoing repeated dialysis, voluntary blood donors and also the incidence of co-infections. Materials and Methods: A serological screening was carried out during the period November 20005 to September 2007 to assess the risk of infection with HIV and co infection with HBV, HCV at Siddhartha Medical College, Vijayawada. A total of 200 samples collected and were tested by ELISA with commercial test kits which were commonly used for HIV, HBV, HCV. Results: Among the 200 samples serological reactivity was detected for HIV in 13(15.5%), HBV in 16(8%), HCV in 18(9%). All the three viruses shown more incidence in STD patients. Co infection with all the three viruses was noted in 3 cases out of 200 cases, which happened to be from STD O.P. 7cases out of 200 cases were positive for HIV and HCV of which all 7 were STD patients. 4 patients from STD group were positive for both HIV and HBV. Conclusion: Screening procedures for hepatotropic viruses and HIV should be made mandatory. Health education to people about Safe Sexual practices and awareness about these viruses.
Asian Journal of Medical Sciences, 2023
Background: Hepatitis B virus (HBV), hepatitis C virus (HCV), and Human immunodeficiency virus (HIV) infections are prevalent throughout the world. HIV infection increases the risk of HBV and HCV liver disease especially when HIV-associated immunodeficiency progresses. Aims and Objectives: This study was carried out with the objectives as follows: Estimation of the prevalence of HIV-Hepatitis co-infection, determine CD4+T lymphocyte count in co-infected patients, identify most common opportunistic infections in HIV-Hepatitis co-infection. Materials and Methods: A hospital-based, prospective, cross-sectional, and observational study was carried among people with confirmed HIV infection. HIV antibody, hepatitis B surface antigen (HBsAg), and HCV antibody tests were done in all patients visiting to integrated counseling and testing center. HIV, HBV, and HCV viral load were done in all serologically confirmed patients. In HBsAg positive patients various markers for hepatitis such as hepatitis B envelop antigen (HBeAg), anti-hepatitis B core antibody (HBcAb), and anti-hepatitis B envelop antibody were also done. Results: Out of 357 people living with HIV/ AIDS (PLHA) patients 15/357 (4.20%) were co-infected with HBV, 03/357 (0.84%) were co-infected with HCV. The overall seroprevalence of Hepatitis virus (HBV+HCV) in PLHA patients was found to be 5.04% (18/357). CD4+T lymphocyte count <200 cells/µL was seen in 66/339 (19.4%), 04/15 (26.6%), and 03/03 (100%) patients of HIV mono-infected, HBV co-infected, and in HCV co-infected patients, respectively. HIV Viral load ≤1000 copies/ mL was seen in 324 and 15 patients in HIV mono-infected and HIV-hepatitis co-infected patient, respectively. Among PLHA patients who were positive for HBsAg; 46.7% (n=7) patients had HBV viral load >2000 IU/mL. All hepatitis B co-infected patients were positive for HBcAb test; HBeAg was positive in 40% (n=06). All HBeAg positive were having viral load >2000 IU/mL. Conclusion: HIV-infected patients are more prone to hepatitis associated liver diseases and exposure to the HBV infection than the general population.
Background: Hepatitis B virus (HBV) and hepatitis C virus (HBV) infections accounts for substantial proportions of the world wide liver disease. The two hepatotropic virus share common modes of transmission and their co-infection are common. Patients with dual HBV and HCV infection have more severe liver disease and are at increased risk of progression to hepatic cell carcinoma. This study was aimed to assess the prevalence of HBV and HCV among patients attending serology laboratory of Gondar University Teaching Hospital. Methods: A retrospective study was conducted from January 2007 to December 2011 at serology laboratory of Gondar University Teaching Hospital. Data were cross checked for completeness, entered and analyzed using SPSS version 16 statistical package. Results: From the total of 2,684 clinicaly suspected hepatitis patients, 563 (20.98%) were positive for HBsAg and anti-HCV test. Of all, 14.4% were seropositive for HBV (male= 7.89% female=6.27%) (p-value=0.011) while 12.4% were seropositive for HCV (male =7.6% and female=4.13%) (p-value<0.001). The coincidence of HBV and HCV were found to be 36 (6.39%) (male=3.9% and female=2.4%) (p-value <0.001). Majority of HBV (30.2%) and HCV (30.7%) infections were detected among age group of 25–34 years old (p-value=0.36) and 15–24 years old (p-value<0.001) respectively.