Effect of Aqueous Extract of Hibiscus Rosa-Sinensis. Linn. On Urinary Volume & Electrolyte Excretion in Albino Rats (original) (raw)

2013, International journal of pharma and bio sciences

Hibiscus rosa-sinensis. Linn grown widely in tropical countries, recently known to have anti-hypertensive effect in the albino rats. This report has shown new dimension to one clinical use & paucity of data available in this regard, the present work is undertaken to study this effect scientifically. Albino rats (100-200gms) deprived of food for 15hrs divided into seven groups of six in each and put in metabolic cages after hydration by normal saline for 24hrs. Aqueous extract of Hibiscus rosa-sinensis was administered in100,200,400 & 600 mg/kg doses per oral. Urinary volume, total Na + , K + , Cl - conc. was estimated at 5 th & 24 th hr and compared with control group. Furosemide 25mg/kg PO was taken as the standard. Aqueous extract of Hibiscus rosa-sinensis(AEHR ) was found to increase the urinary volume of the 5 th hr and 24 th hr sample. Na + & Cl - excretion also significantly increased in 200&400 mg/kg doses. AEHR was found to possesses diuretic activity.

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