Evaluation of Association of Diabetes Mellitus with Head and Neck Cancer: A Cross-Sectional Study (original) (raw)
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Diabetes Mellitus and the Risk for Developing Cancer
2013
Diabetes mellitus is a serious and growing health care problem, globally.The 'westernization' of diets around the world has led to an increase in obesity. Other contributing factors such as smoking, lack of physical activity and aging has led to epidemiological concerns regarding the link between diabetes and cancer. Research evidence suggests that patients with diabetes may be at greater risk for the development of some forms of cancer. The patient being discussed in this case report presented to New York University College of Dentistry (NYUCD), with a history that included type 2 diabetes mellitus, seeking comprehensive dental care. During the interim between his initial exam and following appointment, a lesion had developed on the palate, which was subsequently diagnosed as adenocarcinoma. This prompted the review of current literature, regarding the link between diabetes and the development of various cancers.
Diabetologia, 2017
The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Sig...
Diabetes and Oral Tumors in Hungary: Epidemiological correlations
Diabetes Care, 2004
OBJECTIVE-Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem. RESEARCH DESIGN AND METHODS-Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint-and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients. RESULTS-Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P Ͼ 0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P Ͻ 0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P Ͻ 0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies. CONCLUSIONS-Diabetes may be a risk factor for oral premalignancies and tumors.
Journal of Cancer & Allied Specialties
Purpose: Head and neck cancers (HNC) are among the most common cancers in developing countries, especially in the Southeast Asia. Oral cavity is the most commonly affected site. The risk factors are tobacco, betel nut and alcohol. The dimensions of the disease are quite different in developing countries than the western world. Poor socioeconomic status, poverty, lack of healthcare facilities and illiteracy are the factors that pose a major challenge to the management of the disease. The aim of this study is to analyse the database that has been collected over a period of 10 years showing the trends of the disease and the management outcome of these individuals.Methods: Men and women diagnosed with HNC from 2004 to 2014 from Cancer Registry Database of Shaukat Khanum Memorial Cancer Hospital and Research Centre have been retrospectively analysed.Results: In the 10 year period a total of 5027 patients presented to the head and neck clinic at our institution with a mean age + standard ...
Diabetes has been implicated as an altered risk for development of various cancer types. Aim of the present study was to compare the mortality from malignancies in diabetic and non-diabetic population and to understand the interrelationship between diabetes and cancer. Retrospective observational analysis of data obtained from death certificate providing information about the cause of death, age, sex and identity of decedents from Pune city, excluding the suburbs, was undertaken. Death certificates from January 2006 to December 2006 were analysed. Thirty-two different cancer types were detected in a deceased population of 14,838 with 8% and 6.8% suffering from diabetes and cancer respectively. Out of the total population, 7% of diabetics and 6.8% of the non-diabetics had cancer. Liver (OR = 2.05, 95% CI (1.04-4.04), P = 0.033) and pancreatic (OR = 3.78, 95% CI (1.84-7.73), P = 0.0001) cancer were the major cancer types in diabetic population. Average survival age of breast cancer patients with diabetes was 70.3 years and it was 57.9 years for non-diabetics. We observed that in a given population, there is an increase in the occurrence of certain cancer types under diabetic condition. The present study hints that the interplay between diabetes and cancer in Indian population may be complex and provides impetus for a detailed cohort study.
Diabetes Mellittus and the Risk of Cancer Formation – Possible Link and Review of Literature
American Journal of Internal Medicine, 2015
Background: The incidence of cancer is increased in patients with Type 2 diabetes mellitus. The aetiology is not exactly known. Various studies have been done to ascertain this fact. Aim: The aim of this study was to access the correlation between cancer and diabetes mellitus. Method: Using internet search, a comprehensive literature review was done and words such as diabetes mellitus, cancer, breast, pancreas, colorectal, prostate, liver, were searched from google scholar, yahoo, pubmed, medline, web MD to check for various articles published on this subject. The references of the relevant articles were also searched. Results: Analyses of results of various studies were considered and their RR were noted to access the correlation between cancer and diabetes mellitus. Conclusion: There is an increased fold rise of various cancers among type 2 diabetes mellitus patients.
ecancermedicalscience, 2020
Background: Head and neck cancers are among the commonest cancers in the developing world. Personal habits, such as the use of tobacco, betel nut and alcohol are strongly associated with the development of head and neck cancers at certain sites. Therefore, they are among the preventable cancers. In Bhutan, there has not yet been a study conducted on head and neck cancers. Objective: To describe baseline epidemiological and histopathological characteristics of head and neck cancers in Bhutan. Methods: This is a 7-year descriptive study of all cases of head and neck cancers presented at the Jigme Dorji Wangchuk National Referral Hospital from 2011 to 2017. The data were collected from the hospital's medical records section, histopathology records, patient referral unit and some treatment centres in India. Prior approval was sought from the Research and Ethics Board for Health, the Ministry of Health and the hospital management. Results: There were a total of 515 cases of head and neck cancers from 2011 to 2017. The crude incidence rate was 10 per 100,000 and the overall age adjusted rate was 12.3 (95% CI 9.5-15.1) per 100,000 population. The prevalence during this 7-year period was 69.1 per 100,000 population. The commonest cancers are thyroid, oral cavity, hypopharyngeal, laryngeal and nasopharyngeal cancer in decreasing order. Head and neck cancers are more common in males than females in the majority of sites except thyroid, salivary gland and sinonasal malignancies. Thyroid cancers and nasopharyngeal cancers are found to affect younger age groups. Tashigang (48) followed by Paro (43) recorded the highest number of cases. Squamous cell carcinoma is the commonest histopathology type in almost all the cases, while papillary carcinoma is the commonest among thyroid cancers. Personal habits, such as smoking, chewing tobacco, betel nut and alcohol consumption, were found to be more common among patients suffering from oral cavity, laryngeal, hypopharyngeal and oropharyngeal cancers. Conclusion: Head and neck cancers are the third most common cancer in Bhutan after stomach cancer and cervical cancer. Thyroid, oral cavity and hypopharynx are the top three anatomical sites for head and neck cancers in Bhutan. The current epidemiological and histopathological profile of head and neck cancers will form a baseline of information and basis for further research on head and neck cancers in Bhutan.
Clinical Epidemiology and Global Health, 2015
Cases related to head and neck squamous cell carcinoma (HNSCC) are major clinical challenge in oncology and represent the sixth most common neoplasm in the world today. 1 Worldwide about 650,000 new cases of head and neck cancer (HNC) are reported every year. 2 HNC is the most common cancer in India. 3-5 Mouth and tongue cancers are more common in the Indian subcontinent; nasopharyngeal cancer is more common in Hong Kong, as well as pharyngeal and laryngeal cancers are more common in other populations. Smoking, tobacco and alcohol consumption are main risk factors for HNC. 6 Epidemiological studies also reported a c l i n i c a l e p i d e m i o l o g y a n d g l o b a l h e a l t h 4
The Risk of Cancer in Diabetes Patients: A Review
https://www.ijrrjournal.com/IJRR\_Vol.5\_Issue.8\_Aug2018/Abstract\_IJRR0017.html, 2018
Diabetes and cancer are complicated, severe, homogenous and chronic fatal disease with tremendous impact on worldwide. One of the theory why diabetes and cancer link may exist is that high level of circulating insulin can promote the growth of tumours. The people with diabetes are more risk of many forms of cancer in which cancer is the second leading cause for death and diabetes is the seventh leading cause to death. The common risk factors that link diabetes and cancer is age, sex, obesity, physical activity, increased calorie intake, alcohol and smoking. The mechanism that increases the risk of cancer in diabetic patient is insulin resistance and hyperglycemia which leads to progression of cancer. The risks of cancer are shown to be higher in type II diabetes patients because in type II diabetes the body produces more insulin than normal. Thus we have concluded that diabetes is a high-risk state for several types of cancer. It is increased according to age, sex, obesity and decreased physical activity. The diabetes and cancer risk is higher in obese patients. However, most diabetes is not associated with the risk of cancer. Therefore, we can provide awareness of preventive strategies and public health policies to avoid overlapping burden of both diseases that already have tremendous impact on people health and economy. By providing awareness we can overcome the mortality rate of the both disease.