The Importance of Diet in Predicting the Remission of Urticaria—Determination of Allergen-Specific IgE (original) (raw)
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Background: Atopic dermatitis (AD) is an inflammatory disease of the skin, which is charac-terised by a chronic relapsing course. Aim: The aim of the study was to assign the prevalence of clinically active food allergies among a group of children between 3 months and 7 years of age, with AD. Methods: Eighty-eight children with AD were screened for specific IgE antibodies to food proteins. All patients with AD and specific IgE antibodies to food proteins were subjected to Oral Food Challenges (OFCs) with the relevant foods. Results: Food-sensitised patients with moderate levels of sIgE had clinically active food allergy to milk (39.28%) and egg (42.34%) on the basis of positive OFCs. High IgE and eosinophilia had a prevalence of almost 80% and 25%, regardless of concomitant food sensitisation and disease severity. Conclusions: In this study, clinically active food allergies were recognised in 26.13% of children with AD. Nevertheless, no association was confirmed between food sensitisation and AD severity. High IgE and peripheral eosinophilia have not been found more prevalent among children with severe AD nor among children with food sensitisation. Infants and younger children with AD should be screened for an underlying food allergy, regardless of disease severity.
A Demographics Analysis of IgE- and Non-IgE-mediated Food Allergies in Children
Journal of Kermanshah University of Medical Sciences
Background: There are three broad types of food allergies, including IgE-mediated reactions, non-IgE-mediated reactions, and mixed reactions. The onset of IgE-mediated food allergies is usually rapid and can sometimes lead to serious illness. Non-IgE-mediated and mixed types of food allergies can cause significant morbidity as a result of chronic disease. Objectives: This study aimed to compare various types of food allergies and discuss the basis of their different presentations. Methods: This study was conducted on children aged 2 - 12 years old with signs or symptoms of food allergy in the allergy clinics of Azad University Hospitals, Tehran, Iran, from January 2019 to January 2020. Food allergy was evaluated in these patients by careful history, physical exam, skin prick test, and atopy patch test. Results: A positive family history of atopy was detected in the first-degree relatives of 82 (63%) patients. All the children were exclusively breastfed at the beginning. A total of 6...
International Journal of Environmental Research and Public Health, 2013
IgE-mediated food allergy is a transient condition for some children, however there are few indices to predict when and in whom food allergy will resolve. Skin prick test (SPT) and serum-specific IgE levels (sIgE) are usually monitored in the management of food allergy and are used to predict the development of tolerance or persistence of food allergy. The aim of this article is to review the published literature that investigated the predictive value of SPT and sIgE in development of tolerance in children with a previous diagnosis of peanut, egg and milk allergy. A systematic search identified twenty-six studies, of which most reported SPT or sIgE thresholds which predicted persistent or resolved allergy. However, results were inconsistent between studies. Previous research was hampered by several limitations including the absence of gold standard test to diagnose food allergy or tolerance, biased samples in retrospective audits and lack of systematic protocols for triggering re-challenges. There is a need for population-based, prospective studies that use the gold standard oral food challenge (OFC) to diagnose food allergy at
The Indian journal of chest diseases & allied sciences
Prevalence of immunoglobulin (Ig) E-mediated food allergy is primarily reported for certain pediatric populations and adults. The present study was aimed to investigate the relative prevalence of food allergy and allergens in older children and adults with asthma and allergic rhinitis. Patients (12-62 years) were screened using standard questionnaire and skin prick-test (SPT) with common foods and aeroallergens. Specific IgE level was determined by enzyme linked immunosorbent assay (ELISA) and allergy was established by blinded food challenges. Of 1860 patients screened, 1097 (58.9%) gave history of food allergy. Of the history positive patients skin tested (n=470), 138 (29.3%) showed a marked positive reaction to food extracts. Rice elicited positive SPT reaction in maximum number of cases 29 (6.2%) followed by blackgram 28 (5.9%), lentil 26 (5.5%), citrus fruits 25 (5.3%), pea 18 (3.8%), maize 18 (3.8%) and banana 17 (3.6%). The SPT positive patients showed elevated specific IgE l...
IgG food hypersensitivity: A potential hidden precipitant for chronic spontaneous urticaria
Allergologia et immunopathologia, 2023
Background: While the link between foods and chronic spontaneous urticaria (CSU) is controversial, many immunological mechanisms have been proposed to establish a causal relationship. Objective: To explore the potential benefit of avoiding immunoglobulin G (IgG)-mediated food hypersensitivity as a triggering factor in a case with CSU. History: The patient is a 50-year-old woman who complained of CSU for 1 and half year, which responded partially and temporarily to antihistamine medications. Of interest, it started 6 months after she followed an oat-rich diet. Her Urticaria Activity Score 7 was 23 out of 40. Results: Specific immunoglobulin E responses to common food and inhalant allergens were negative. A food-specific IgG antibody test was conducted, and it was mainly elevated for chicken eggs, rye, sweet pepper, gluten, garlic, wheat, and pineapple. Avoiding these foods had a curative effect on the CSU over a 2-month period. Conclusion: To the best of our knowledge, this is the first case report of symptoms of CSU that resolved after identifying and avoiding food items with IgG antibodies. Furthermore, well-controlled studies are advocated to verify the potential role of IgG food hypersensitivity in the pathogenesis of CSU.
Food allergy test in chronic urticaria adult patients: A cross sectional study
IP innovative publication pvt. ltd, 2019
Introduction: Chronic urticaria is a distressing cutaneous allergic condition with diverse clinical presentations which can affect the physical and psychological aspects of both adult and paediatric group of patients. Food allergens are considered to be one of the common aetiology in adult chronic urticaria patients. The best way to prevent it is by taking specific measures to avoid or reduce the consumption of offending food allergens that causes signs and symptoms, suspected food allergies should be evaluated clinically, diagnosed with skin prick test as well as blood test and treated by a qualified medical professional. Materials and Methods: This is a cross –sectional study conducted in 100 adult chronic urticaria patients visiting the out-patient department of dermatology, Azeezia medical college, Kollam from a period of December 2017 to December 2018. This study was conducted to know the prevalence of food allergens in chronic urticarial patients with the help of skin prick test with 32 food antigens. Results: Almost 99% of patients with chronic urticaria had some sorts of food allergy. Major offending food allergens were Haldi (16.2%), cashew nut (14.1%), mustard (12.1%), saunf (12.1%), milk and chicken (11.1%), garlic, ginger, gram, apple and fish (9.1%), banana and coffee (8.1%). Conclusion: Food allergy is one of the common cause for cutaneous distressing diseases like chronic Urticaria, which can impair the mental and physical well-being of patients. Specific diagnosis, evaluation and treatment of the above mentioned condition can improve the general aspects of urticarial patients. Main offending food allergens were Haldi (16.2%), cashew nut (14.1%), mustard (12.1%), saunf (12.1%), milk and chicken (11.1%), garlic, ginger, gram, apple and fish (9.1%), banana and coffee (8.1%). Skin prick test is one of the cheapest and fairly effective tool in the diagnosis of Chronic Idiopathic urticaria.
Iranian journal of allergy, asthma, and immunology, 2017
IgE- mediated food allergy affects 6-8% of children. Our study aimed to define the correlations between the results obtained with skin prick tests (SPTs) using commercial extracts and fresh foods, and the correlations between these result and those obtained with specific IgE (sIgE) and/ or challenge. Children aged from 2 months to 6 years were recruited prospectively. Overall 571 children were positive to one food. In all children we performed SPT using commercial extracts of suspected food and fresh foods and sIgE. If SPT and sIgE test results did not correspond to the history, we performed open oral food challenge. Sensitivity of SPT with commercial extracts for all tested food was poor (3-35%), while sensitivity of fresh food skin prick tests (FFSPT) was excellent (50-100%), and showed correlation with open oral food challenge (p<0.001). Our results suggest that fresh food extracts are more effective in detecting sensitization and with levels of sIgE greater than class 3 cou...