Bayesian Network Approach to Estimate Gene Networks (original) (raw)

Concepts, Methodologies, Tools, and Applications

In cells, genes interact with each other and this system can be viewed as directed graphs. A gene network is a graphical representation of transcriptional relations between genes and the problem of estimation of gene networks from genome-wide data, such as DNA microarray gene expression data, is one of the important issues in bioinformatics and systems biology. Here, we present a statistical method based on Bayesian networks to estimate gene networks from microarray data and other biological data. Because microarray data are measured as continuous variables and the relationship between genes are usually nonlinear, we combine Bayesian networks and nonparametric regression to handle continuous variables and nonlinear relations. Most parts of gene networks are still unknown, and we need to estimate them from observational data. This problem is equivalent to the structural learning of Bayesian networks, and we solve it from a Bayes approach. The main difficulty of gene network estimatio...

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