An In Vitro Antibacterial and Cytotoxic Potentials of Bioactive Metabolites Extracted from Padina tetrastromatica (original) (raw)
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Nowadays marine algae are having a numerous commercial applications in various fields. Marine algae produce 60 trace elements in a concentration much higher than in terrestrial plants then the macroscopic marine algae also contain protein, iodine, bromine, vitamins and substances of stimulatory and antibiotic nature. This present study was summarized to the antimicrobial activity of the organic solvents of the Marine alage Padina tetrastromatica and phytochemical analysis of Padina tetrastromatica with various organic solvents such as Acetone, Ethanol, Ethyl acetate, Methanol and Tolune . The antibacterial activity against Bacillus subtilis, Proteus sp and Streptococcus sp in various solvents extracts of Padina tetrastromatica. The higher inhibitory activity was in Ethyl acetate extracts of Padina tetrastromatica and lesser inhibitory effect was in Acetone. The responsible functional groups in the solvent extract were identified by Fourier Transform Infrared (FTIR). Mostly marine algal products play a crucial role in various fields. May it's become even more diversified and economically competitive.
International Journal of Zoology and Applied Biosciences, 2017
Marine macroalgae like Padina Gymnospora are used in traditional remedies in many parts of the world. In the present study, the extracts of P. gymnospora have been shown to have antibacterial activity in vitro against Gram-positive and Gram-negative bacteria. The pharmaceutical properties and anti-microbial activities were considered to be an indicator of the capacity of the macro algae to synthesize bioactive secondary metabolites. It have been identified that the macro algae P.gymnospora per 100 g contain 5.0 g protein, 0.30 g fat, 4.2 g fiber, 3.4 g Ash, 1.4 mg niacin, 190 mg ascorbic acid, 0.7 mg Ca, 4.1 mg P, 21 mg Na, and 16 mg K. Apart from that the P. gymnospora shows the phyto pharmaceutical compounds such as alkaloids, flavanoids, tannis, terpanoids and phenolic compounds. They have known to show medicinal activity as well as exhibiting antibacterial activity.
The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved to survive the high concentrations of infectious and surface-fouling bacteria that are indigenous to ocean waters. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion. The resistance of pathogenic bacteria to existing antibiotics has become a global epidemic. Marine algae derivatives have shown promise as candidates in novel, antibacterial drug discovery. The efficacy of these compounds, their mechanism of action, applications as antibiotics, disinfectants, and inhibitors of foodborne pathogenic and spoilage bacteria are reviewed in this article.
Screening of the Antibacterial Activity of Some Marine Algae Against Fish and Human Pathogens
2009
This study aims to investigate the effect of some algal extracts as antibacterial agents against some pathogenic bacteria. Thus the ethyl acetate and methanolic extracts of the marine algae Ulva lactuca, Enteromorpha compressa, Ulva fasciata, Pterocladia capillacea, Corallina mediterranea, Hypnea musciformis and Padina pavonia, collected from the coast of Alexandria (Egypt), were tested as antibacterial agents against fish and human pathogenic bacteria; Aeromonas hydrophila, Vibrio anguillarum, Pseudomonas fluorescens, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhimurium. The best activities were shown by the methanolic-L extract of P. capillacea against P. fluorescens, V. anguillarum and P. aeruginosa. The methanolic-L extract of U. lactuca showed high activity towards A. hydrophila, V. anguillarum, P. fluorescens and S. aureus. Cluster analysis was used to study the action of the crude algal extracts.
Antimicrobial Action of Compounds from Marine Seaweed
Marine Drugs, 2016
Seaweed produces metabolites aiding in the protection against different environmental stresses. These compounds show antiviral, antiprotozoal, antifungal, and antibacterial properties. Macroalgae can be cultured in high volumes and would represent an attractive source of potential compounds useful for unconventional drugs able to control new diseases or multiresistant strains of pathogenic microorganisms. The substances isolated from green, brown and red algae showing potent antimicrobial activity belong to polysaccharides, fatty acids, phlorotannins, pigments, lectins, alkaloids, terpenoids and halogenated compounds. This review presents the major compounds found in macroalga showing antimicrobial activities and their most promising applications.
Antibacterial activities of different extracts of some fresh and marine algae
The in v itro antimicrobial activity of algal extracts belonging t o two species of microalgae; Chlorella vulgaris, Spirulina p lat ensis and two species of seaweeds; Sargassum vulgare and Sargassum w ightii were tested against m ethicillin-resistant Staphylococcus aureus (MRS A) and m et hicillin-sensitive S. aureus (MSS A) clinical isolates. In this study, microtiter plate reader assay m ethod was used to eluci date the effects. The ext racts were prepared in four different solvents, out of whi ch methanol extracts showed better and promising result s. The results also confirm ed the potential use of algal extracts as a source of antimicrobi al compounds.
Journal of Applied Pharmaceutical Science, 2020
Marine microalgae have been reported as an excellent source of bioactive compounds. The present study analyzes the existence of bioactive phytochemicals and their efficacy in antimicrobial activity against aquatic pathogens. The antimicrobial compounds were extracted from three marine microalgae, namely Chlorella sp., Pavlova sp., and Chaetoceros sp., and Pavlova sp. showed a broad spectrum of activity. Pavlova sp. extracts were tested against the selected aquatic pathogens, such as Vibrio harveyi, Vibrio parahaemolyticus, Pseudomonas aeroginosa, Aeromonas hydrophila, and Staphylococcus aureus, and the result showed the inhibiting activity against aquatic pathogens. The minimum inhibitory concentration and minimum bactericidal concentration, cytotoxic assay, and mode of action were also studied. The effective five crude extracts were purified by column chromatography and tested against the pathogens; then, the active fraction was partially characterized by Fourier transform infrared (FTIR) analysis. The FTIR result suggested the presence of bioactive groups, such as amines, alkane, carboxylic acid, sulfoxide, alcohol, boron, etc. From the five extracts, two active extracts were selected and subjected to TLC (Thin layer chromatography). The cytotoxic activity (LD-50) indicates that the compound may be safe and effective for clinical trial. Finally, the algal cytotoxic assay concluded that the isolated compound can also be used as an algicide to control algal blooms. This study proves that Pavlova sp. is an excellent source of pharmacologically active resourceful algae and shows effective activity against aquatic pathogens.
Bioactive Compounds from Bacteria Associated to Marine Algae
Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life, 2012
Biotechnology-Molecular Studies and Novel Applications for Improved Quality of Human Life 26 characteristics, have attracted attention on either a big quantity of investigators on a global scale in the search of new natural products with anticancer and antibiotic activity principally.
Natural Compounds with Bioactive Properties from Marine Algae
Medicinal and Aromatic Plant Science and Biotechnology, 2010
Algae, mainly of marine origin, are producers of many economically important compounds. These compounds are bioactive compounds since they have different biological activities and have been used in the nutraceutical, pharmaceutical and cosmetic industries for many years. Recent trends in drug research from natural sources and several screening and clinical studies have led to the discovery and elucidation of a number of new and active compounds from macroalgae. This review covers those algae from which bioactive substances have been identified and/or synthesized with a potential impact on health and medicine.