The impact of plasma rich in growth factors on clinical and biological factors involved in healing processes after third molar extraction (original) (raw)
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BMC Oral Health
Background The surgical extraction of impacted third molars is one of the most common procedures in oral and maxillofacial surgery, which associated with several postoperative complications. The aim of this clinical trial was to estimate the implication of concentrated growth factor (CGF) on postoperative sequelae after the completely impacted lower third molar extraction. Materials and methods A total of 74 sides of 37 participants who had completely bilateral impacted lower third molars were enrolled in this split-mouth, randomized single‑blind, clinical trial. Surgical extraction was undertaken on both sides of the mandible. Randomization was achieved by opaque, sealed envelopes. The postoperative outcomes including wound healing, swelling and pain were clinically assessed at different-time intervals(1st, 3rd and 7th days). A p-value < 0.05 was considered statistically significant. Results The wound healing index was significantly better in the test sides (P = 0.001). Regardin...
Journal of Evidence Based Dental Practice
Purpose The purpose of this study was to determine whether the adjunctive use of plasma rich in growth factors in postextraction sites could be beneficial in terms of hard-/ Q2 soft-tissue healing and patients' comfort. Materials and Methods An electronic search was performed on MEDLINE, EMBASE, Scopus, and CENTRAL. Only controlled clinical trials or randomized clinical trials that used plasma rich in growth factors in the test group were included. The primary outcomes were pain assessment, complications, and adverse events. Secondary outcomes were hard-tissue healing, bone remodeling, and soft-tissue healing. Results Eight comparative studies (5 randomized clinical trials) were included. Four studies had a split-mouth design. Six hundred fourteen teeth were extracted in 338 patients. Only qualitative analysis could be performed. Postoperative pain and the incidence of complications such as alveolar osteitis were consistently lower in the test group. Hard-tissue healing, evaluated by clinical, radiographic, histologic, and histomorphometric techniques, showed significantly better results for the test group in almost all studies. Better epithelialization, keratinized tissue thickness, and healing score were also reported. Conclusion Plasma rich in growth factors may bring advantages in some relevant clinical and radiographic outcomes, such as bone density and soft-tissue healing, after tooth extraction. It could also represent a useful tool for reducing adverse events, complications, and patients' discomfort, although it is still not quantifiable.
Medicina oral, patología oral y cirugía bucal, 2009
To apply autologous Plasma Rich in Growth Factors (PRGF) in wounds provoked in the tongue of New Zealand albino rabbits and to study its effects in the epithelialization and inflammation of the wounds at 7 and 28 days after its application. A prospective study carried out on 20 adult rabbits. Two wounds were made on the midline of the dorsal surface of the tongue in each animal, one control, and the other in which PRGF was applied. A histological study of the epithelialization and inflammation of wounds at 7 and 28 days was made. At 7 days were not observed differences between the study group and the control, nevertheless at 28 days all the wounds in which we applied the PRGF were completely epithelialized and with resolution of the inflammatory process, finding significant differences with respect to the control (p=0.031) and (p=0.023). The PRGF accelerates epithelialization and reduces inflammation at 28 days of provoking wounds in the oral mucosa.
Plasma rich in growth factors in dentistry
Australasian Medical Journal, 2017
Background Plasma rich in growth factors (PRGF) has wider use in many fields of dentistry due to its endogenous biocompatible regenerative potential i.e., their potential to stimulate and accelerate tissue healing and bone regeneration. Aims This review shows the increasing use of PRGF technology in various fields of dentistry. Methods In the last nine years PubMed has been searched in order to find out published articles upon PRGF in dentistry and 36 papers have been included. Results PRGF technology has many advantages with positive clinical and biological outcomes in tissue healing and bone regeneration. Conclusion In order to determine the most effective therapeutic value for patients, further research is required.
Healing of Alveolar Sockets Treated with Concentrated Growth Factors: A Split-Mouth Study
Materials
Background: tooth extraction is a common procedure in oral surgery. The socket healing process involves hard and soft tissues and is characterized by intense remodeling, which may determine consistent dimension changes. Several autologous platelet concentrates (APCs) proved to be effective for enhancing alveolar socket healing after tooth extraction, accelerating socket closure and countering alveolar bone resorption. Concentrated growth factors (CGFs) are one of the most recently developed APCs, and their effect on the socket healing process still needs to be confirmed. Aim: The aim of the present split-mouth study was to evaluate the effectiveness of CGFs in enhancing the healing process in the postextraction alveolar socket and reducing postoperative pain. Methods: One hundred and fifty-four extractions were performed. One of the extraction sockets of each patient was treated with CGFs (test site), and the other socket was unfilled (control site). The main outcomes were: healing ...
Photomedicine and Laser Surgery, 2016
Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-b 1 , platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-b 1 , PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-b 1 , PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-b 1 , PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-b 1 levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-b 1 , PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators.
2020
Aim: The aim of this study is to evaluate the changes in the serum levels of interleukin-6 after impacted third molar surgery and its relation with the degree of the operative difficulty. Materials and methods: This prospective cohort study included patients who underwent surgical extraction of impacted mandibular third molar. Two blood samples were drawn from the patients; one before the operation and the second 48 hours postoperatively. The serum interleukin-6 levels were measured using the enzyme-linked immunosorbent assay (ELISA) and the differences between the pre and postoperative levels were assessed and correlated with the difficulty of surgical extraction determined by duration and technique of surgery and other variables. Results: Thirty nine patients were included: 12 (30.8%) males and 27 (69.2%) females. The age range was from 20-38 years, with a mean ± SD of 29 ± 5 years. The level of interleukin-6 increased significantly following surgery in comparison with the level b...
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2020
This prospective study was designed to assess the efficacy of autologous PRP gel in healing of extraction socket after surgical extraction of impacted mandibular third molar. Methods: A total of 100 patients necessitating treatment were randomly allocated in two groups; experimental and control. In experimental group, PRP gel was placed in the extraction socket after extraction, whereas in control group the similar procedure was carried out without application of PRP gel. The outcome variables were pain, swelling, and maximum mouth opening, which were assessed on 1st, 3rd, 5th, 7th and 14th day following extraction. Socket healing was analyzed radiographically by allocating scores for overall density and trabecular pattern on 4th, 10th and 16th week postoperatively. Results: Results showed significant lower pain scores, reduced facial swelling and improved interincisal opening in experimental group postoperatively when compared to control group. The bone density and trabeculae pattern in both groups didnot show any difference at 4th week. However, highly significant difference (P value < 0.005) was observed between both groups radiographically at 10th and 16th weeks following extraction. Conclusions: The present study concludes that the use of simple, cost-effective method of autologous PRP gel may be beneficial to enhance the wound healing process and promotes bone regeneration.
Journal of Oral and Maxillofacial Surgery, 2011
Purpose: This investigation assesses the effect of platelet-rich plasma (PRP) gel on postoperative pain, swelling, and trismus as well as healing and bone regeneration potential on mandibular third molar extraction sockets. Patients and Methods: A prospective randomized comparative clinical study was undertaken over a 2-year period. Patients requiring surgical extraction of a single impacted third molar and who fell within the inclusion criteria and indicated willingness to return for recall visits were recruited. The predictor variable was application of PRP gel to the socket of the third molar in the test group, whereas the control group had no PRP. The outcome variables were pain, swelling, and maximum mouth opening, which were measured using a 10-point visual analog scale, tape, and millimeter caliper, respectively. Socket healing was assessed radiographically by allocating scores for lamina dura, overall density, and trabecular pattern. Quantitative data were presented as mean. Mann-Whitney test was used to compare means between groups for continuous variables, whereas Fischer exact test was used for categorical variables. Statistical significance was inferred at P Ͻ .05. Results: Sixty patients aged 19 to 35 years (mean: 24.7 Ϯ 3.6 years) were divided into both test and control groups of 30 patients each. The mean postoperative pain score (visual analog scale) was lower for the PRP group at all time points and this was statistically significant (P Ͻ .05). Although the figures for swelling and interincisal mouth opening were lower in the test group, this difference was not statistically significant. Similarly, the scores for lamina dura, trabecular pattern, and bone density were better among patients in the PRP group. This difference was also not statistically significant. Conclusion: The PRP group recorded reduced pain, swelling, and trismus as well as enhanced and faster bone healing compared with those in the control. Hence the study showed that topical application of PRP gel has a beneficial effect in enhancing socket healing after third molar surgery.