Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models (original) (raw)

Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentrati...

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