Patterns of thrombospondin genes polymorphisms in acute myocardial infarction patients in Ismailia city (original) (raw)

Abstract

ABSTRACT Thrombospondin (TSP) 2 and 4 are multidomain calcium-binding extracellular glycoproteins which play a role in platelet aggregation and inflammatory response. TSP-2 has chemotactic and mitogenic activities for vascular smooth muscle cells while TSP-4 mRNA is expressed by endothelial and smooth muscle cells in vascular wall, and brain endothelial cells produce the protein both in vivo and in cell culture, localization consistent with its pro-atherogenic effects. These common functions may be central to the roles of the thrombospondins in coronary artery disease and myocardial infarction (MI). In the present study, the association of the TSP-2 (3949 T→G, rs8089) and TSP-4 (Ala387Pro 1186 G→C, rs1866389) gene variations and MI among Egyptian patients living in Ismailia city has been examined. Both rs8089 and rs1866389 were studied in 50 acute MI patients and 50 controls using Real-Time polymerase chain reaction. The prevalence of TSP-2 and TSP-4 alleles was not different in MI ...

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