Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases (original) (raw)

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

Howard Robinson

Biochemistry, 2008

View PDFchevron_right

Classification of Phosphodiesterases and the Therapeutic Effects of their Inhibitors (Review

IJSES Editor

View PDFchevron_right

Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity

Hengming Ke

Current Topics in Medicinal Chemistry, 2007

View PDFchevron_right

Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors

ana castro

Medicinal Research Reviews, 2005

View PDFchevron_right

Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity

Hengming Ke

Journal of Biological Chemistry, 2004

View PDFchevron_right

Pharmacologic activity of phosphodiesterases and their inhibitors

Romeo Cristina

View PDFchevron_right

Adenine Nucleoside 3'-Tetraphosphates Are Novel and Potent Inhibitors of Adenylyl Cyclases

Laurent Desaubry

Journal of Biological Chemistry, 1998

View PDFchevron_right

Combined ligand based pharmacophore modeling, virtual screening methods to identify critical chemical features of novel potential inhibitors for phosphodiesterase-5

Chandrasekaran Meganathan

Journal of the Taiwan Institute of Chemical Engineers, 2011

View PDFchevron_right

A stimulating effect of guanyl nucleotides on the rat-liver soluble cyclic GMP high-affinity phosphodiesterase activity

Annamaria Spina

FEBS Letters, 1983

View PDFchevron_right

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis † , ‡

Hengming Ke

Biochemistry, 2003

View PDFchevron_right

Advances in targeting cyclic nucleotide phosphodiesterases

Vincent Manganiello

Nature Reviews Drug Discovery, 2014

View PDFchevron_right

Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

Ahmad Fawzi

Bioorganic & Medicinal Chemistry Letters, 1999

View PDFchevron_right

Moueqqit Mohammed

European journal of biochemistry / FEBS, 1989

View PDFchevron_right

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

George Baillie

Nature Reviews Drug Discovery, 2019

View PDFchevron_right

An Improved, Automated Adenylate Cyclase Assay Utilizing Preparative HPLC: Effects of Phosphodiesterase Inhibitors

Richard Mailman

Journal of Neurochemistry, 1984

View PDFchevron_right

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

Howard Robinson

Biochemical Journal, 2007

View PDFchevron_right

The N-Terminal Domain of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase Harbors a GTP/ATP Binding Site

Fabrizio Piaz

Chemical Biology & Drug Design, 2007

View PDFchevron_right

Isolation of cyclic AMP and cyclic GMP by thin-layer chromatography. Application to assay of adenylate cyclase, guanylate cyclase, and cyclic nucleotide phosphodiesterase

James Keirns

Analytical Biochemistry, 1974

View PDFchevron_right

Inhibition of Phosphodiesterase Type 5 by the Activator of Nitric Oxide-Sensitive Guanylyl Cyclase BAY 41-2272

Florian Mullershausen

Circulation, 2004

View PDFchevron_right

Structural Basis for the Inhibition of Mammalian Membrane Adenylyl Cyclase by 2 ′(3′)-O-(N-Methylanthraniloyl)-guanosine 5 ′-Triphosphate

Andreas Gille

Journal of Biological Chemistry, 2004

View PDFchevron_right

Identification of Inhibitor Specificity Determinants in a Mammalian Phosphodiesterase

Daniel Susanto

Journal of Biological Chemistry, 1999

View PDFchevron_right

Toward the identification of the cardiac cGMP inhibited-phosphodiesterase catalytic site

Raffaella Boggia

Journal of computer-aided molecular design, 1998

View PDFchevron_right

Differential Inhibition of Various Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by 2',3'-O-(2,4,6-Trinitrophenyl)-Substituted Nucleoside 5'-Triphosphates

Andreas Gille

Journal of Pharmacology and Experimental Therapeutics, 2009

View PDFchevron_right

Analysis of cyclic nucleotide phosphodiesterase(s) by radioimmunoassay

Samuel Strada

Archives of Biochemistry and Biophysics, 1982

View PDFchevron_right

Crystal Structure of the Catalytic Fragment of Human Brain 2′,3′-Cyclic-nucleotide 3′-Phosphodiesterase

Yasumitsu Sakamoto

Journal of Molecular Biology, 2005

View PDFchevron_right

Comparison of cyclic nucleotide phosphodiesterase isoforms from rat heart and bovine aorta

C. Lugnier

Biochemical Pharmacology, 1988

View PDFchevron_right

2`,5`-Dideoxyadenosine 3`-Polyphosphates Are Potent Inhibitors of Adenylyl Cyclases

Laurent Desaubry

Journal of Biological Chemistry, 1996

View PDFchevron_right

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

Sanjay Bhattarai

Frontiers in pharmacology, 2017

View PDFchevron_right

Exploring the origin of phosphodiesterase inhibition via proteochemometric modeling

S. Shirin Shahangian

RSC Advances, 2017

View PDFchevron_right

Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

W. Filipowicz

Biochemical and Biophysical Research Communications, 2002

View PDFchevron_right

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases (original) (raw)

Related papers