Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother's HBsAg seropositivity (original) (raw)
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Seroprevalence of Toxoplasmosis in Pregnant Women in Daejeon, Korea
Laboratory Medicine Online, 2011
Background: Toxoplasma gondii can cause devastating disease in the fetus and newborn infant. Serologic testing of pregnant women for Toxoplasma-specific antibodies can be used to identify those women at risk of transmitting Toxoplasma gondii infection. In Korea, despite a few reports on the seroprevalence of Toxoplasma (Toxo) antibody, the incidence of acute or chronic toxoplasma infection during pregnancy has not been well established. We performed a prospective screening for Toxoplasma antibodies to obtain a basic epidemiological data on the seroprevalence of acute and chronic toxoplasma infection. Methods: During a 6-month period, 787 pregnant women at various weeks of gestation were enrolled in the prospective study. Toxo IgG and IgM antibodies were determined by the Abbott AxSYM Toxo IgG and IgM assays. Serum specimens showing positive results of both IgG and IgM antibodies were further tested using the Abbott ARCHITECT Toxo IgG Avidity test. Results: The seropositivities of Toxo-specific IgG and IgM antibodies in this cohort were 2.3% (18/787) and 0.1% (1/787), respectively. No woman showed positive results for both Toxoplasma IgG and IgM antibodies. One specimen showing IgG positive and IgM grayzone results was tested by Toxo IgG avidity test and a low avidity test result (9%) was obtained, suggesting a possible acute primary infection. Conclusions: This study was the first trial on the investigation of the seroprevalence of both IgG and IgM antibodies in Korea, and we found that the seroprevalence of the antibodies was lower than that previously reported.
Report on the External Quality Assessment Scheme of Hepatitis Viral Markers in Korea, (2016-2017)
Journal of Laboratory Medicine and Quality Assurance, 2018
As part of the immunoserology program of the Korean Association of External Quality Assessment Service, we organized two trials on the external quality assessment of hepatitis viral markers in 2016 and 2017. The hepatitis viral antigens and antibodies program consisted of 10 test items. We delivered two and three types of pooled sera specimens to 965 and 965 institutions for the first and second trials of external proficiency testing in 2016, respectively. The number of participating laboratories was 915 (94.8%) and 913 (95.0%) in the first and second trials in 2016, respectively. We also delivered three kinds of pooled sera specimens to 936 and 1,015 institutions for the first and second trials of external proficiency testing in 2017, respectively. The number of participating laboratories was 920 (98.3%) and 996 (98.1%) in the first and second trials in 2017, respectively. The most commonly tested items were hepatitis B surface antigen, followed by the antibodies to hepatitis B surface antigen, anti-hepatitis C virus, hepatitis B envelope antigen, antibodies to hepatitis B envelope antigen, anti-hepatitis A virus and antibodies to hepatitis B core antigen. The most frequently used methods for detecting viral markers were the chemiluminescence immunoassay and the electrochemiluminescence immunoassay, but they yielded a few-false positive results due to the matrix effect. The immunochromatographic assay yielded falsenegative results for anti-hepatitis A virus due to low sensitivity. Continuous improvement in the quality of viral hepatitis testing through participation in the survey seems necessary.
Objectives: This study aims to assess the stages of individual readiness to take the cancer screening test and to identify factors relating to the progress of their readiness to take the test. Methods: We analyzed the data acquired from our 'Cancer Screening Behavior among Korean Adults' Survey' in 2003. 1,057 participants' stages of readiness to take the cancer screening test were classified through the Precaution Adoption Process Model (PAPM). Their knowledge, beliefs and other factors related to cancer screening were examined at each PAPM stage through the Health Belief Model (HBM), and the various PAPM stages were compared with each other to identify factors likely to determine progress between stages. Results: The distribution of the PAPM stages of readiness for cancer screening was as follows: 18.9% were unaware; 9.7% were unengaged; 29.8% were deciding to take the test; 1.5% decided not to take the test; 11.6% decided to take the test, while 28.6% had taken th...
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2015
Background/Aims: Helicobacter pylori eradication rates achieved by first-line triple treatment with proton pump inhibitor (PPI), clarithromycin, and amoxicillin have decreased to 70∼85%, in part due to increasing antimicrobial resistance. This study evaluated the trend in H. pylori eradication rates during the most recent 8 years in Daegu, Korea and analyzed different clinical factors between success group and failure group of H. pylori eradication. Materials and Methods: This was a retrospective study at a single institution. A total of 768 H. pylori-positive patients who received one or two weeks of first-line triple regimens were included between January 2007 and October 2014. Results: The overall H. pylori eradication rate was 86%. The eradication rate from years 2007 to 2014 was 80.5%, 89.4%, 95.6%, 85.5%, 87.9%, 75.8%, 83.3%, and 85.8%, respectively (P=0.027). There was no significant difference in the eradication rate among various PPIs (P=0.358). In addition, there were no significant difference of clinical factors between success and failure group of H. pylori eradication. Conclusions: The eradication rates of first-line triple therapy for H. pylori over 8 years were 75.8∼95.6%. No significant difference in clinical factors were noted between success and failure group of H. pylori eradication. Triple therapy may be a useful regimen for
The Journal of Korean Oriental Pediatrics, 2013
The goal of the present study was to elucidate the characteristics of behavior problems in Sasang typology with child patients. Methods Subjects consisted of 176 (95 boys, 81 girls) children from 36 months to 83 months were diagnosed by two clinical experts in pediatrics and Sasang medicine. There were 22 So-Yang types, 141 Tae-Eum types, and 13 So-Eum types. The behavior problems were measured with Child Behavior Checklist (CBCL) and ANOVA (analysis of variance) was used for the analysis. Results There were no significant differences between Sasang types among subject's age (F(2, 173)=.190, p=.827) and sex (χ 2 (2, N=176)=1.639, p=.441) as well as their mother's age (F(2, 169)=.060, p=.942) and education level (χ 2 (4, N=172)=.394, p=.983) and their father's age (F(2, 168)=1.184, p=.309) and education level (χ 2 (4, N=172)=5.664, p=.226). So-Yang types (50.14±22.35; 17.27±8.60) had higher scores than Tae-Eum types (38.74±21.32; 12.62±7.98) in total problems and internalizing problems score of the CBCL, respectively. More specifically, So-Yang types (5.90±2.81; 3.77±1.90) had significantly higher depression/anxiety and somatization subscale score than Tae-Eum types (4.04±2.73; 2.30±2.12). Scores of So-Yang types were significantly higher than those of CBCL clinical group in depression/anxiety and somatization subscales. Conclusions There were significant differences between child outpatients with different Sasang types, which would be taken into consideration concerning development of Sasang type diagnosis in addition to parenting, treatment, and prevention for children.
Journal of Life Science, 2019
Saposhnikovia has been used as a traditional medicinal herb in Asia because of the reported anti-inflammatory, anti-allergic rhinitis, pro-whitening, anti-atopy, anti-allergy, and anti-dermatopathy effects of the phytochemical compounds it contains. In this study, we investigated the antioxidant effects of a Saposhnikovia extract after fermentation by Lactobacillus plantarum BHN-LAB 33. Saposhnikovia powder was inoculated with L. plantarum BHN-LAB 33 and fermented at 37℃ for 72 hr. After fermentation, the total polyphenol content of the Saposhnikovia extract increased by about 14%, and the total flavonoid content increased by about 9%. The superoxide dismutase-like activities, DPPH radical scavenging, ABTS radical scavenging, reducing power activity, and tyrosinase inhibition activity also increased after fermentation by approximately 70%, 80%, 45%, 39%, and 44%, respectively. The results confirmed that fermentation of a Saposhnikovia extract by L. plantarum BHN-LAB 33 is an effective way to increase the antioxidant effects of the extract. The bioconversion process investigated in this study may have the potential to produce phytochemical-enriched natural antioxidant agents with high added value from Saposhnikovia matrices. These results can also be applied to the development of improved foods and cosmetic materials.
Laboratory Medicine Online, 2016
Background: Many molecular diagnostic methods have been developed to detect sexually transmitted infections (STI). The STDetect Chip (Lab-Genomics, Korea) which is a DNA microarray-based tool, newly developed for STI diagnosis in vitro, and the real-time PCR-based Anyplex STI-7 (Seegene, Korea) in clinical use were evaluated using ATCC DNA and clinical samples to determine the clinical usefulness of the STDetect Chip. Methods: The two methods were compared for consistency, sensitivity, and specificity for 6 pathogens in 300 prospectively selected clinical samples. Analytical sensitivity for ATCC Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma hominis and Trichomonas vaginalis DNA and the effect of mixing bacterial DNA were studied. Results: The consistency of the two methods for clinical samples was superior at more than 0.92 kappa value. The sensitivity and specificity of the STDetect Chip compared with Anyplex STI-7 were 90.5-98.8%, and 95.6-99.6%, respectively. With similar analytical performance for ATCC DNA, the STDetect Chip detected 10-5 ng/μL of N. gonorrhoeae, 10-4 ng/μL of C. trachomatis, 10-6 ng/μL of M. hominis, and 10-3 ng/μL of T. vaginalis. For the mixture of three bacterial DNAs, less sensitive detection level was observed for T. vaginalis. Conclusions: The STDetect Chip showed good agreement with the Anyplex STI-7 test and it is considered clinically useful for detecting sexually transmitted pathogens.
모-자녀 기질 적합성과 자녀의 문제행동간의 관련성 연구
The Journal of Korean Oriental Pediatrics, 2013
Objectives The purpose of this study was to identify the importance of goodness of fit in mother-child temperamental interaction (MCTI) and the child problem behaviors. Methods The behavior problem of 180 child outpatients from traditional Korean medical clinic was measured with Korean version of Child Behavior Checklists, and the temperament of child and their mother was measured with Junior Temperament and Character Inventory and Temperament and Character Inventory-Revised-Short. The MCTI was calculated as the difference of the temperament score between mother and child. The correlation and linear regression analysis was performed to examine the effects of temperament on Child Behavior Checklists. Results The MCTI on Harm-Avoidance was the significant factor for explaining the internalizing problem (B=-.154, t=-10.130, p<.001), externalizing problem (B=-.045, t=-3.340, p=.001) and total problem (B=-.298, t=-7.574, p<.001). We also confirmed that the temperament of mother and child significantly correlated with the child behavior problems as provided previously. Conclusions These results showed that the temperament interaction between mother and child is an important factor for predicting problem behaviors in child clinical sample. The goodness of fit in MCTI and problem behavior should be considered as pivotal element in traditional Korean pediatrics.