Textual reading comprehension and naming in Alzheimer's disease patients (original) (raw)
Related papers
Journal of Communication Disorders, 1997
The narrative production of adults with probable dementia of Alzheimer's type (DAT) was investigated to determine the extent to which cognitive or linguistic deficits might explain the breakdown of discourse production. The structure of narrative tasks was manipulated so that the relationships among task structure and language production corresponded to predictions about the suspected origin of deficit. Sixteen DAT and 16 normal control subjects were administered four narrative tasks that were controlled for the amount of content and picture format display. The DAT subjects exhibited reduced content in terms of propositions and lexical items, shorter sentence lengths with more sentence fragments and reference errors. The mode of picture display failed to influence the amount of target content, or the grammatical performance of subjects. However, when compared to the normal controls, the amount of information pictorially represented significantly influenced the content provided by the DAT subjects; they performed better when the message to be related contained relatively less information. These findings support the contributions of both semantic-lexical and ideational systems to narrative discourse production.
Narrative analysis in Alzheimer’s disease
Psychology in Russia: State of the Art, 2018
Background. Alzheimer's Disease (AD) is a neurodegenerative illness, which occurs with increasing frequency as people age. While progressive memory impairment is the upfront element associated with the disease, other neurocognitive troubles are also associated with it, such as language impairment which can degenerate into aphasia. Language disorders interfere and worsen the functioning of memory. Aim of the study. To evaluate semantic and textual impairment in AD patients. Methods. The current study involved 151 AD patients undergong consultation at Brest University Hospital. Certain sociodemographic data (sex, age, cultural levels) were collected, as well as results from the following neuropsychological tests: Folstein (MMSE); Dubois's 5-word test; Dubois's frontal assessment test battery (fluencies); Cornell's scale for depression; and Barbizet's test ("The Lion's tale"). All were subject to textual analysis. Our sample of demented patients included 102 females and 49 males of average age 80.3 ± 6.91. Results. All the tests, including the number of items recalled much later in the Barbizet's test, showed impairment, all the more by Folstein's test being altered. The demented patients' formal fluency was less impaired than their semantical lexical fluency (scored respectively 5.74 ± 1.09 versus 4.41 ± 2.19; t = 5.60, p < 0.01). The demented cohort exhibited more intrusions (n = 36) than inversions in the delayed recollection of the Lion's Tale, both for items and the episodes in which they occurred (n = 19). The regressive PLS analysis showed that, to explain the overall scores relating to "The Lion's Tale", calculated later, only attainment of lexical fluency had any notable influence (Regression coefficient CR = 0.224) or, more accessorily, the cultural level (CR = 0.12). Conclusion. AD patients' proficiency in tests of category fluency and their cultural levels have effects on narrativity.
A linguistic profile of narrative speech in early and late Alzheimer's disease
2021
Objective. Alzheimer's Dementia is defined as multiple impairments in cognitive functions and language impairment is one of the observed problems in this disease. In order to analyse these problems, narrative speech transcriptions of Turkish patients with early and late-onset Alzheimer's Disease (AD) and an age/education-matched control group were examined. Materials & Methods. By using different language tests, the sentence production of Turkish patients with early (n: 23) and late-onset (n: 39) was examined and the results A Linguistic Profile of Narrative Speech in Early and Late-Onset... 29 © Can Eda & Kuruoğlu Gülmira were compared within groups and within language tests. Our aim was to reveal the differences in sentence processing of Turkish Alzheimer patients. Results. According to the results, Turkish Alzheimer patients use short and simple sentences composed of fewer words in their speech. It was determined that these patients performed better in Picnic Picture Description test, which is thought to be easy to describe. In Cookie Theft Picture Description test, which is a complex one, and in the Subject-based Narration test, it was found that the speech amounts of AD patients were less. It was revealed that early-onset AD patients used shorter sentences including fewer words compared to late-onset AD patients. Conclusions. In the light of the data obtained, it can be said that AD patients have different sentence processing than normal individuals because of the problems in the language and memory areas of the disease. The fact that sentence processing is different means that these patients do not prefer the types of sentences that normal individuals prefer in their speeches, and use less words and simpler sentences.
Selective Naming (and Comprehension) Deficits in Alzheimer's Disease
Cortex, 2007
The present study compared object and action naming in patients with Alzheimer's dementia. We tested the hypothesis put forward in (some) previous studies that in Alzheimer's dementia the production of verbs, that is required in action naming, is better preserved than the production of nouns, that is required in object naming. The possible reason for the dissociation is that verbs are supported predominantly by frontal brain structures that may remain relatively better preserved in early Alzheimer's disease. Objects, on the other hand, are supported by temporal lobe structures that are aVected early in the disease. An alternative hypothesis, which is supported by other studies, is that action naming is more impaired than object naming due to verbs being semantically more complex than nouns. In order to test these contrasting hypotheses, the present study used more stringent methodology than previous studies. We used a larger set of stimuli with carefully matched object and action items and we collected not only accuracy data but also naming latencies, a measure that is sensitive to even mild lexical retrieval problems. We compared the performance of 19 patients with mild to moderate Alzheimer's disease with that of 19 healthy age matched participants. We found that both the patients and the comparison group responded faster and made fewer errors on the object pictures than the action pictures. A qualitative analysis of the naming errors indicated that object and action naming pose diVerent demands for the language system. The results overall suggest that the patients' performance is an exaggeration of the pattern present in the comparison participants.
A Linguistic Profile of Narrative Speech in Early and Late-Onset Alzheimer’s Disease
PSYCHOLINGUISTICS
Objective. Alzheimer’s Dementia is defined as multiple impairments in cognitive functions and language impairment is one of the observed problems in this disease. In order to analyse these problems, narrative speech transcriptions of Turkish patients with early and late-onset Alzheimer’s Disease (AD) and an age/education-matched control group were examined. Materials & Methods. By using different language tests, the sentence production of Turkish patients with early (n: 23) and late-onset (n: 39) was examined and the results were compared within groups and within language tests. Our aim was to reveal the differences in sentence processing of Turkish Alzheimer patients. Results. According to the results, Turkish Alzheimer patients use short and simple sentences composed of fewer words in their speech. It was determined that these patients performed better in Picnic Picture Description test, which is thought to be easy to describe. In Cookie Theft Picture Description test, which is a ...
Object and Action Naming in Alzheimer's Disease
Cortex, 1998
We administered measures of object naming and action naming to matched groups of ten patients with Alzheimer's disease (AD) and ten normal control subjects. AD patients were impaired in both object and action naming, with object naming impaired to a significantly greater extent than action naming. This difference remained after controlling for the effects of word frequency. We propose that the pattern of pathological changes in AD impairs both conceptual and lexical retrieval systems for objects but only conceptual systems for actions. The similar patterns of error during the two tasks suggest quantitative rather than qualitative differences in the breakdown of the two abilities.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Introduction: The depiction of features in discourse production promotes accurate diagnosis and helps to establish the therapeutic intervention in cognitive impairment and dementia. We aimed to identify alterations in the macrolinguistic aspects of discourse using a new computational tool. Methods: Sixty individuals, aged 60 years and older, were distributed in three different groups: mild Alzheimer's disease (mAD), amnestic mild cognitive impairment, and healthy controls. A narrative created by individuals was analyzed through the Coh-Metrix-Dementia program, extracting the features of interest automatically. Results: mAD showed worse overall performance compared to the other groups: less informative discourse, greater impairment in global coherence, greater modalization, and inferior narrative structure. It was not possible to discriminate between amnestic mild cognitive impairment and healthy controls. Discussion: Our results are in line with the literature, verifying a pathological change in the macrostructure of discourse in mAD.
Is action naming better preserved (than object naming) in Alzheimer’s disease and why should we ask
Brain and Language, 2006
The present study compared object and action naming in patients with Alzheimer's dementia. We tested the hypothesis put forward in (some) previous studies that in Alzheimer's dementia the production of verbs, that is required in action naming, is better preserved than the production of nouns, that is required in object naming. The possible reason for the dissociation is that verbs are supported predominantly by frontal brain structures that may remain relatively better preserved in early Alzheimer's disease. Objects, on the other hand, are supported by temporal lobe structures that are aVected early in the disease. An alternative hypothesis, which is supported by other studies, is that action naming is more impaired than object naming due to verbs being semantically more complex than nouns. In order to test these contrasting hypotheses, the present study used more stringent methodology than previous studies. We used a larger set of stimuli with carefully matched object and action items and we collected not only accuracy data but also naming latencies, a measure that is sensitive to even mild lexical retrieval problems. We compared the performance of 19 patients with mild to moderate Alzheimer's disease with that of 19 healthy age matched participants. We found that both the patients and the comparison group responded faster and made fewer errors on the object pictures than the action pictures. A qualitative analysis of the naming errors indicated that object and action naming pose diVerent demands for the language system. The results overall suggest that the patients' performance is an exaggeration of the pattern present in the comparison participants.
2020
Due to advances in the early detection of Alzheimer's disease (AD) biomarkers including beta-amyloid (Aβ), neuropsychological measures that are sensitive to concurrent, subtle changes in cognition are critically needed. Story recall tasks have shown sensitivity to early memory declines in persons with Mild Cognitive Impairment and early stage dementia, as well as in persons with autosomal dominantly inherited AD up to 10 years prior to a dementia diagnosis. However, the evidence is inconclusive regarding relationships between evidence of Aβ and story recall measures. Because story recall tasks require the encoding and delayed retrieval of several lexical-semantic categories, such as proper names, verbs, and numerical expressions, and because lexical categories have been shown to be differentially impaired in persons with MCI, we focused on item-level analyses of lexical-semantic retrieval from a quintessential story recall task, Logical Memory from the Wechsler Memory Scale. Our...