Rajasekaran A Protective effects of Capparis zeylanica Linn. leaf extract on gastric lesions in experimental animals (original) (raw)
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Avicenna journal of medical biotechnology, 2011
The aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of Capparis zeylanica Linn on experimental animal models. The methanol extract of Capparis zeylanica Linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. HCl-Ethanol induced ulcer in mice and indomethacin induced ulcer in rats at 200 mg/kg body weight p.o. A significant (p<0.01, p<0.001) anti-ulcer activity was observed in all the models. Pylorus ligation showed significant (p<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 88.5% ulcer inhibition in HCl-ethanol induced ulcer and 83.78% inhibition in indomethacin induced ulcer.
Antiulcer activity of ethanolic leaf extract of Capparis zeylanica against chemically induced ulcers
Future Journal of Pharmaceutical Sciences, 2021
Background Peptic ulcer is the term which refers to acid peptic injury of the digestive tract, and it results in mucosal break reaching the submucosa. Leaves of Capparis zeylanica are used as counterirritant, rubefacient, as a cataplasm in piles, boils and swellings. The objective of the present study was to evaluate the antiulcer activity of C. zeylanica ethanolic extract against chemically induced ulcers. The leaves were extracted with ethanol (50%) as solvent using hot perforation method. The extract was evaluated against acute and chronic ulcer models. Further, extract was evaluated for gastric autopsy of animals infected with Helicobacter pylori bacteria. The genes of rats were evaluated by gel electrophoresis method. Morphology of stomach was also studied after treatment with plant extract. Results Results exhibited that the area of ulcer was significantly reduced in both acute [naproxen-induced ulcer model (3.62 mm2), histamine-induced ulcer model (3.2 mm2) and ethanol-induce...
Journal of Pharmaceutical Research
The objective of the study was to investigate the possible effects of 50% ethanolic extract of Capparis zeylanica (CZE) on gastric secretion and Phenylbutazone ulcer in rats. Approach: Twenty four adult male rats were used in this study (four groups) and several parameters were determined to assess any degree of protection. The ulceration was induced by Phenylbutazone at a dose of 100 mg/kg b.w. Findings: Phenylbutazone toxicity induced + CZE treated rats showed a significant decrease (p < 0.001) in volume of gastric juice, free and total acidity, pepsin concentration and acid output with a significant increase (p < 0.001) in pH compared to Phenylbutazone toxicity induced rats. Phenylbutazone caused a significant decrease (p < 0.001) in TC:P with a concomitant increase (p < 0.001) in protein and DNA. After treatment of CZE in rats, a significant increase (p < 0.001) in the carbohydrate concentration in terms of TC:P ratio and significantly lowered (p < 0.001) protein concentration in gastric juice was observed. CZE tended to increase mucin activity in Phenylbutazone + CZE group. Conclusion: It can be concluded that CZE imparted a protective action against phenylbutazone induced chronic ulcer in rats.
Journal of chemical and pharmaceutical research, 2021
Background: Most parts of Capparis cartilaginea plant especially the leaves are used to treatment of many diseases such as skin inflammation, bruises, swellings, rheumatism, cough, indigestion, colics...etc. The leaves of C. cartilaginea are used traditionally in many areas of Yemen for heartburn/peptic ulcers, itching, shortness of breath and tumors. Objective: To evaluate the potential anti-ulcer effect of C. cartilaginea leaves in experimental animals. Method: 15 male rabbits were divided into 5 groups. Each group contains 3 rabbits, Ulceration was induced in the groups II-V rabbits with indomethacin (40 mg/kg body weight, oral intubation) dissolved in distilled water, while group I was kept as a control and it was only given the vehicle oral dose of gum acacia in distilled water (2% w/w). Results: The results showed that the leaves of C. cartilaginea have a significant effect (P<0.05) as anti-ulcer when compared to the indomethacin-induced gastric ulcer group (Group II). It was found that seven days post-ulcerative treatment with the C. cartilaginea leaves extracts was optimal for the effective healing of gastric ulcer. Conclusion: Through this study, we conclude that the extracts of C.cartilaginea leave have anti-ulcerogenic activity and they can be used to treat gastric ulcer.
International Journal of Research in Medical Sciences
Background: Peptic ulcer disease is a non-malignant, mucosal lesion of the stomach or duodenum. The mucosal defect reaches the muscularis mucosa and sometimes, beyond causing life threatening complications, including haemorrhage, perforations, gastrointestinal obstruction and malignancy.Methods: The animals were pre-treated with omeprazole 20 mg/kg and 300 mg/kg of Capparis cartillaginea decne orally for 14 days. On the 15th day, ulcers were induced using indomethacin 30 mg/kg and 4 hours post ulcer induction, they were sacrificed. Ulcer index, pH, total acidity and volume were determined.Results: Extensive lesions were seen in indomethacin ulcerated rats with mean ulcer score of (1.260±0.18). In comparison, there were minimal areas of erosion on animals pre-treated with omeprazole (0.14±0.025) and plant extracts (0.280±0.097). Indomethacin-induced ulcer treated animals showed the highest volume of gastric juice output (3.14±0.21 ml), whereas the animals pre-treated with omeprazole ...
Anti-Ulcerogenic Effect of Some Indian Medicinal Plants on Mucosal Lesion in Rats
The antiulcer activity of the poly herbal formulation (composed of the leaf extracts from Lantana camara, Annona muricata, Kalanchoe pinnata) was evaluated in necrotizing agents induced ulcer model in rats. The extract at dose of 1000mg/kg produced significant inhibition of gastric lesion induced by above mentioned method. The extract reduced ulcerative lesion, gastric volume, free and total acidity and pH of gastric juice in the model. The result obtained suggesting that extract possesses significant anti-ulcer activity.
AN REVIEW ARTICLE ON THE ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANTS
Peptic ulcer is one of the most common gastrointestinal diseases. The exact causes of peptic ulcer disease are not known but it may be result from an imbalance between acid-pepsin secretion and mucosal defence factors. Peptic ulcer disease occurs mainly due to consumption of NSAIDs, infection by H. pylori, stress, or due to a pathological condition such as Zollinger –Ellison Syndrome. Nature provides a number of medicines and perhaps all solutions for human illnesses. So far, nature supplies many clinically useful drugs. Ulcer is a major increasing health problem. Nowadays, there are several synthetic medications available for the treatment of peptic ulcers, but these drugs are expensive and are likely to produce more side effects than herbal drugs. Certain antiulcer drugs such as proton pump inhibitors and H2 receptor antagonists are used to treat peptic ulcers. However, these drugs have shown disease relapse, side effects, and even drug interactions. Numerous medicinal plants have anti-ulcer activity and are useful in the treatment of peptic ulcers. The aim of this review is to find out more about the anti-ulcer properties of herbal medicines. The present article reviews the antiulcerogenic and ulcer healing property of Ocimum sanctum, Allophylus serratus, Desmodium gagenticum, Azadirachta indica, Hemidesmus racemosus, Asparagus racemosus, and Musa sapientum. We have brought to light some of the important plants reported for their anti-ulcer and ulcer healing properties. Ayurvedic knowledge supported by modern science is necessary to isolate, characterize and normalize the active components of herbal sources for antiulcerative activity. KEYWORDS: Antiulcer activity, Ethanolic extract, Aspirin-induced ulcer model, NSAIDs.
Evaluation of Anti-Ulcer activity of Capsicum annuum fruit extract by using Pylorus Ligation Model
International Journal of Current Trends in Pharmaceutical Research , 2016
Many herbalists believe that Capsicum annuum (cayenne) is the most useful and valuable herb in the herb kingdom, not only for the entire digestive system, but also for the heart and circulatory system. Because it acts as a catalyst and it increases the effectiveness of other herbs when used along with them. Because of its ability to stimulate the circulatory and digestive systems, it has a tonic and antiseptic affect as well. The present study aims to evaluate the anti-ulcer activity of C. annuum chloroform extract. Anti-ulcer activity was evaluated by Pylorus ligation model (shay model) in rats (adult male albino; weighing 180 to 220 g). Changes in the gastric secretion volume, pH, Ulcer Index, Free acidity and Total acidity and Acid volume were observed in rats. C. annuumantagonized histaminic effects on gastric juice volume, pH and pepsin activities. Fraction also inhibited gastric ulcer formation induced by Pylorus ligation model in this study. The anti-ulcer effects of C. annuum found comparable to the Ranitidine, a reference anti-ulcer agent.
IN VIVO GASTRO-PROTECTIVE EFFECTS OF FIVE MOROCCAN MEDICINAL PLANTS AGAINST GASTRIC ULCER
Centaurea chamaerhaponticum Ball. (Asteraceae), Lawsonia inermis L. (Lythraceae), Origanum compactum Benth. (Lamiaceae), Punica granatum L. (Punicaceae) and Ceratonia siliqua L. (Sapindaceae) are medicinal plants recommended in Moroccan folk medicine for the treatment of gastric ulcers. The protective effects of the studied plants against gastric damage were investigated using three experimental models in rats (HCl/ethanol, pylorus ligation, and aspirin-induced ulcer). Each plant extract (250 or 500 mg/kg) was orally administered once prior to ulcer induction. The antiulcer activity was assessed by comparing the ulcer index and gastric parameters in the test group with those of the control group. As a result, all five plant extracts showed, at the high dose, a significant gastro-protective effect. O. compactum showed the highest ulcer protective in NSAID-induced ulcer model (86.1 % of protection), greater than that of omeprazole (79.7 %) and almost similar to that of cimetidine (84.8%). The volume of gastric secretion was decreased significantly by C. chamaerhaponticum (50% of gastric secretion reduction), C. siliqua (46.4%) and L. inermis (42.8%) similarly to omeprazole’s antisecretory effect (50% of secretion reduction). A significant decrease in the total acidity was noticed only at the highest dose for all tested plants (percent of total acidity reduction ranged from 22.2 to 30.5 %), except for C. chamaerhaponticum which showed no significant modifications in both total acidity and gastric pH. Taken together, the results of this study indicate that the selected plants possess potent gastroprotective and antisecretory properties, which justify the ethno-medicinal claims.
Journal of Ethnopharmacology, 1995
Anti-ulcerogenic activity of the methanolic extracts of 4 medicinal plants were studied in aspirin-induced gastric ulcers in rats. Their effects on the volume of gastric juice secreted, acid output, peptic activity, mucin activity and curative ratio were recorded. Bauhinia racemosa (flower buds) decreased the ulcer index significantly, and Moringa pterygosperma (flower buds) showed some decrease in the ulcer index. Trianthema pentandra (whole plant) did not show any decrease in the acid or pepsin content or any increase in mucin; however, it showed a highly significant decrease in the ulcer index. Cordia latifolia (ripened fruit) did not however decrease the ulcer index.