[Malignant priapism and secondary bladder cancer] (original) (raw)
Cureus
Priapism is one of the most common urologic emergencies and is characterized by a prolonged and painful erectile state unrelated to sexual stimulation or sexual desire. Neoplasm-associated priapism is a rare condition and is usually caused by corporeal metastases of other pelvic area malignancies. Primary penile malignancy-related malignant priapism is extremely rare. In this reported case, an 82-year-old male presented with priapism. The penile doppler ultrasound and pelvic magnetic resonance imaging were compatible with ischemic priapism and corporal mass. Subsequently, the patient underwent total penectomy and bilateral superficial inguinal lymphadenectomy. The pathology report was consistent with primary penile squamous cell cancer (SCC), so the patient underwent adjuvant radiotherapy. However, he developed multiple metastases and could survive for about six months. The patient had undergone radical cystectomy (RC) and urethrectomy 19 and 2 years ago due to urothelial carcinoma, respectively. To the best of our knowledge, this is the second case of malignant priapism due to primary penile SCC and represents one of the longest urethral recurrence periods after RC. When a patient presents with malignant priapism, primary penile malignancies should be considered in differential diagnosis, even if the patient has a history of pelvic area malignancies.
Asian Journal of Medical Sciences, 2013
Metastatic neoplasms of the penis are uncommon. The most common primary organs have been reported to be the bladder and prostate. In the present report, a patient with priapism was demonstrated to have carcinoma prostate complicated with penile, lung, and liver metastasis in the absence of bone involvement and normal serum PSA levels.DOI: http://dx.doi.org/10.3126/ajms.v4i2.7827 Asian Journal of Medical Sciences 4(2013) 51-54
Cases Journal, 2009
Metastatic involement of penis is an exceptionally rare condition. 77% of the metastases are originated from the pelvic region; prostate and bladder are the most frequent primary locations. Retrograde venous route, retrograde lymphatic route, arterial spread, direct extension, implantation and secondary to instrumentation are the mechanisms of metastasis. Approximately two thirds of all penile metastasis are detected at a mean time of 18 months after the detection of the primary tumor and the remaining one third is presented at the same time with primary tumor. Diagnosis is usually made by biopsy and also non invasive methods as MRI or colour-coded duplex ultrasonography. Treatment options in these patients are local excision, partial or complete penectomy, external beam radiation therapy and chemotheraphy. Despite these alternatives prognosis is usually poor.
High flow malignant priapism with isolated metastasis to the corpora cavernosa
Urology, 1998
Malignant priapism is a rare disease with only 88 reported cases. We present a case of a patient with priapism secondary to isolated metastasis to corpora cavernosa from bladder tumor. Metastasis to penis usually represents evidence of a more widespread disease in 80% to 90% of the patients. Rarely, as in this case, the metastasis is solitary.
Penile metastasis from invasive bladder cancer
Acta chirurgica iugoslavica, 2009
Objective: To present the rare case of penile metastasis from bladder cancer. Patient report: A 68-year-old man with invasive bladder cancer disseminated in penile shaft and the pelvic lymph nodes is presented. The patient underwent cystoprostatectomy, total penectomy and adjuvant chemotherapy. Results: Ten months after surgery, patient is in complete remission. Conclusion: Despite the fact that secondary penile tumors usually require palliative therapy, in selected cases surgical treatment of primary tumor and penectomy, followed with chemotherapy, can improve survival.
A rare case of penile metastasis of testicular cancer presented with priapism
Hinyokika kiyo. Acta urologica Japonica, 2005
Priapism is thought as a condition of penile erection that persists beyond or is unrelated to sexual stimulation. Commonly two different entities of priapism are known, one is low-flow priapism and the other is high-flow priapism. It is important to distinguish these two conditions for the subsequent different treatments. We report a rare case of an indistinguishable priapism caused by penile metastasis of testicular cancer.
Prognosis of men with penile metastasis and malignant priapism: a systematic review
Oncotarget, 2018
Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease. We reviewed the literature relating to all case reports, series and reviews about penile metastasis, from 2003 to 2013, through a Medline search. We identified 63 articles and 69 patients. Metastases were located on the root (38.8%), the shaft (38.8%) or the glans (22.2%) of the penis. The diagnosis of penile metastasis was made after the primary cancer had been diagnosed. The most common presentation was a single small penile nodule. Ten patients reported priapism. The median survival time after diagnosis of penile metastasis was 10 months (range 6-18 months). A Kaplan-Meier analysis has shown that the patients presenting with priapism and those with metastases from non-urologic tumors have a significantly worse prognosis (age adjusted Log Rank: p=0.037 fo...
Transitional cell carcinoma of the bladder metastatic to the penis
Urology, 2004
Transitional cell carcinoma of the bladder has the potential to metastasize to multiple organs, and the vascularity of the penis makes it a potential site for hematogenous metastases. We present 2 cases of transitional cell carcinoma with metastases to the penis, with a review of the published reports involving penile metastases. We also discuss the presentation of penile metastases and relevant management issues in these patients who typically have quite advanced disease at presentation. UROLOGY 63: 981.e1-981.e3, 2004.
Penile gangrene: An unusual complication of priapism in a patient with bladder carcinoma
Journal of Surgical Technique and Case Report, 2011
A 40-year-old, apparently healthy farmer presented with a 4-day history of progressively painful penile erection with no known predisposing or precipitating factor. He had an emergency El-Ghorab shunt which resulted in almost complete detumescence. He was noticed to have developed ischemic changes of the distal part of the penile skin which progressed to gangrene of the distal part of the penis on the 4th day post intervention. Abdomino-pelvic ultrasound revealed an intravesical mass and urine and corpus cavernosa aspiration cytology were positive for malignant cell. The patient, however, declined further treatment and was discharged against medical advice.
Penile metastasis from primay mucinous adenocarcinoma of bladder
Indian Journal of Urology, 2007
Primary adenocarcinoma of the urinary bladder is not common. Though penile metastases from transitional cell carcinoma are reported, such metastases from adenocarcinoma of urinary bladder is unknown. We report a 55-year-old male having penile metastasis from primary mucinous adenocarcinoma of bladder.
Malignant priapismus induced by adenocarcinoma of the prostate
Urology Case Reports, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Secondary penile tumours revisited
International seminars in surgical oncology : ISSO, 2006
To highlight the salient features of metastatic malignancies involving the penis, with special reference to the primary tumour sites, metastatic mechanisms, clinical features, differential diagnosis, treatment and prognosis. A comprehensive search of the literature was performed using MEDLINE and EMBASE, using the keywords 'penis', 'secondary malignancy', 'metastasis' and 'malignant priapism' to identify reviews and case reports of secondary penile malignancy. A case of rare clinical presentation of metastatic penile lesion is presented along with the review of the literature. Secondary malignancy of the penis is a rare clinical entity, despite the rich vascularisation of this organ. The majority of metastatic lesions take their origin from the neighbouring genito-urinary organs, mainly prostate and bladder. These lesions are often associated with disseminated malignancy and hence have a poor outcome. Nodular or ulcerative lesions involving the corpor...
Medical Journal of Clinical Trials & Case Studies
Background: Metastatic transitional cell carcinoma in the penis is extremely rare. Symptoms like penile pain, swelling, or priapism should raise the suspicion, when they happen in a known case of invasive bladder cancer. Case presentation: We report an unusual case of penile pain and swelling in a 69-year-old man, known to have invasive bladder cancer that was initially treated with radiotherapy. Although both penile ultrasound and MRI suspected hematoma or scarring rather than malignancy, the penile biopsy confirmed metastatic transitional cell carcinoma. Conclusion: Metastatic urothelial carcinoma in the penis is a rare presentation with poor prognosis, where treatment options are very limited and mainly palliative.
Penile metastasis from prostate cancer: a case report
Tumori
Metastatic involvement of the penis is rare. About 80% of secondary lesions originate from pelvic primary tumors, mainly bladder and prostate. We present a case of prostatic mucinous adenocarcinoma with penile metastasis symptomatic for pain, which was treated with external-beam radiation (35 Gy/14 fractions; 2.5 Gy daily) combined with androgen deprivation, resulting in complete pain relief and objective response after treatment.
Penile metastases of prostate cancer
Acta clinica Croatica, 2011
Prostatic adenocarcinoma metastasizing to the penis is rare. A case of prostatic adenocarcinoma with metastases to the glans penis is presented. In this case, penile metastases developed nine years after the diagnosis of prostate cancer with regional lymph node metastasis.
BMC cancer, 2004
Almost one-third of all penile metastases are detected at the same time as a primary tumor, whereas the remaining two-thirds are detected a mean of 18 months after the discovery of the primary tumor. Cutaneous metastasis of transitional cell carcinoma (TCC) is extremely rare and generally accepted as the late manifestation of a systemic spread. We report the first case of simultaneous penile and lung metastases from a primary TCC of the renal pelvis in a 76-year-old man, that occurred 8 years after a left nephroureterectomy. This case report underscores the importance of physical examinations of the skin of patients who undergo surgical procedures for TCC from bladder as well as from the upper urinary tract, including those seemingly without metastatic disease, because of the possibility of skin and penile metastatic spread.