Refractoriness to platelet transfusion in the presence of anti-HLA antibodies—reassessing the alloantibody hypothesis (original) (raw)

Refractoriness to platelet transfusion, particularly in the context of anti-HLA antibodies, presents a critical challenge in treating thrombocytopenic patients. While humoral alloimmunization has been the accepted explanation for this condition, emerging evidence suggests the potential role of CD8+ T cells in mediating platelet clearance, even in the absence of detectable alloantibodies. This paper reassesses the alloantibody hypothesis, arguing for the exploration of alternative explanations like the CD8+ T cell hypothesis that remain consistent with available data.