The 18F PET/CT scan in patients with chronic sarcoidosis (original) (raw)

1.5 Diffuse Parenchymal Lung Disease, 2016

Abstract

Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New markers of activity are important due to lack of sufficiently sensitive and specific .The aim : Performed 18F-FDG PET / CT scan in clinical problems of chronic sarcoidosis. Method: Previously histological obtained sarcoidosis are enrolled : 58 patients (mean age 54.4 ± 12 years ; 23 – 40% men and 35-60% women). PET scan performed and also after 20 months of finished therapy. Resuls: PET scan is verified inflammation in 54(93.1%)patients (SUVmax 8.84 ± 3.52). MDCT scan was positive in 49(84,48%) patients. Significant difference between the two methods not verified (p = 0.238, McNemar9s test).Spirometry findings:Ventilatory restriction is the main findings in 22 % and obstruction findings in 8 (14%) patients- age over 50 years with fibrotic chest ray findings. Markers of activity are higher in patients with positive findings on 18F-FDG PET / CT scan , compared to the group with negative results (p = 0.002, Mann-Whitney test). Specified group of 16( 28%) patients with positive PET but normal ACE and Ca in 24h urine,was obtained .Chitotriosidase levels significantly correlated with the findings of the 18F-FDG PET / CT scan in 57 patients. Logistic regression (univariate and multivariate) indicates significant correlation (p=0.001),positive PET scan findings and the modifying treatment. Control findings of PET scan after 14-22 months, obtaine reduction in SUV (8.84 vs.4.4) . Located SUV were significantly correlated with the subjective perception of the state of patients (P = 0.019). Conclusion: 18F-FDG PET / CT scan is the significant diagnostic method in determining the sites of inflammation in patients with chronic sarcoidosis.

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