Distribution of 3H-domperidone, a P-glycoprotein (P-gp) substrate, in heart structures and whole-body tissues of MDR1A (−/−) mice (original) (raw)

Clinical Pharmacology & Therapeutics, 2005

Abstract

Background: Block of voltage-gated cardiac K+ channels and drug-induced Long QT syndrome have been reported with domperidone. We hypothesized that accumulation of domperidone in the heart could occur in the context of decreased activity of the ABC transporter P-gp (mdr1a (−/−)), thus leading to cardiac toxicity. The aim of our study was to determine whether distribution of domperidone to the

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