Dynamic contrast enhanced ultrasound imaging; The effect of imaging modes and parameter settings for a microvascular phantom (original) (raw)

2018

Abstract

Dynamic contrast enhanced ultrasound (DCE-US) imaging has the potential to provide quantitative information which is sensitive to tumour perfusion, an indicator for tumour response to radiotherapy. To increase the reproducibility of time-intensity curve (TIC) characteristics, we are developing a 3 DDD DCE-US imaging system. There are, however, many choices to be made in system design, such as whether to use plane wave (PWI) or focused imaging (FI), and the values to use for parameters such as focal depth (FD), F-number (F#), mechanical index (MI) and number of angles (NA) (for PWI). We evaluated the effect of such choices on TICs (we refer to time-amplitude curve (TAC) here), using a microvascular flow phantom containing sim100,000\sim 100, 000sim100,000 parallel microtubes, each 200mutextm200\mu \text{m}200mutextm in diameter. DCE-US 2D images were obtained using a Vantage (Verasonics Inc.) and a pulse-inversion algorithm. 800 frames were recorded at 10 Hz for PWI and FI. All measurements were repeated 3 times, injec...

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