Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections (original) (raw)

Science, 2002

Abstract

To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2 + T cell responses to mycobacterial infections. These phosphoantigen-specific γδ T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2 + T cells were also seen during Mycobacterium tuberculosis infection of naı̈ve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vγ2Vδ2 + T cells may contribute to adaptive immunity to mycobacterial infections.

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