Biomarkers in lung cancer: integration of genomics with radiotherapy response data (original) (raw)

Abstract

Lung cancer is the neoplasia with higher incidence and mortality in men and women worldwide. Lung cancer is classified into two large histologic subgroups: small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) according to cellular origin, molecular changes, clinical-pathological features, and response to treatments. The NSCLC constitutes 80% of the all cases of lung cancer; nevertheless the molecular mechanisms underlying the tumoral etiology still remain poorly understood. MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs that negatively regulate gene expression at the post-transcriptional level by repressing translation or decreasing mRNA stability in numerous biological processes. In cancer, miRNAs have spatial and temporal expression, which is related with several clinical, biological, molecular and genomic features of tumors. miRNAs expression profiles, polymorphisms and epigenetic modification in NSCLC have been studied, and they have i...

Claudia Haydée hasn't uploaded this paper.

Let Claudia know you want this paper to be uploaded.

Ask for this paper to be uploaded.