To Study the Relationship Between the Glycosylated Hair Protein and HBA1C for Assessment of Blood Glucose Level in Diabetes Mellitus Type II (original) (raw)

BACKGROUND: Hair is a dead tissue and is composed of keratin and related proteins. Hair is a protein offew growing cells at the base of the hair root. If the patient is diabetic glycosylation occurs in these growingcells.Since the extent of glycation of hair protein varies with the distance from the hair root, we hypothesizedthat glycation of hair protein might provide insight into blood glucose level over a period of several mouthsto one year.So hemoglobin Ale (HbAIc) may be established as an indicator of long-term blood glucosecontrol in diabetic patients. It is formed by non-enzymatic reaction of glucose with Hb.The objective of thisstudy was to estimate the furosine(an intermediate in the breaking down of amadori compounds likeglycosylated proteins) level by HPLC of glycosylated hair proteins, to find interrelation of fasting glucosewith HbAIc and furosine in diabetic patients, to determine the efficacy of Glycosylation of HbA,c andfurosinemay be a reliable marker in diabetic pa...