Vitamin D and Its Relationship with the Pathways Related to Thrombosis and Various Diseases (original) (raw)
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International Journal of Hematology and Blood Disorders, 2017
International Journal of Hematology and Blood Disorders Open Access Mini Review Although several studies have been conducted regarding this subject, data from human studies are less conclusive than in vitro Analytical Comparison between Microhematocrit and Automated Methods for Packed Cell Volume (PCV) Determination Augmentation of anticoagulant effect with vitamin D: possible therapeutic target for venous thromboembolism
Iranian journal of pharmaceutical research : IJPR, 2014
Low plasma level of vitamin D is linked to the increased risk of cardiovascular diseases such as hypertension, diabetes, dyslipidemia and peripheral vascular diseases. Vitamin D deficiency is a worldwide problem that involves Iranian population. To the best of our knowledge, this was the first investigation on venous thromboembolism (VTE) subjects that assessed the correlation of vitamin D level with plasma P-selectin, hs-CRP, and risk factors of thrombosis. In this prospective pilot study, patients with diagnosis of acute deep vein thrombosis and/ or pulmonary embolism were enrolled. All patients' clinical data, demographics and risk factors of thrombosis were evaluated. Plasma level of P-selectin and hs-CRP were measured by ELISA method. Radio immune assay method was used to determine plasma level of 25-hydroxy vitamin D (25(OH) D). In this study, 60 subjects were included. The mean ± SD plasma 25-hydroxy vitamin D level (25(OH) D) of participants was 21.4 ± 14.6 ng/mL. The vi...
Clinical and Applied Thrombosis/Hemostasis, 2013
Objective: The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI). Methods: Patients who had 25-hydroxyvitamin D3 (25(OH)D3) levels measured were included. Coagulation and hemostatic parameters were evaluated. Patients were divided into 3 groups based on 25(OH)D3 levels as group 1 (25(OH)D3 < 10 ng/mL, n = 25), group 2 (25(OH)D3 = 10-19.9 ng/mL, n = 22), and group 3 (25(OH)D3 ≥ 20 ng/mL, n = 28). Results: A total of 75 patients with a mean age of 39 (range 18-57) years were included in the study. Prothrombin time was longer in group 3 than in group 2 ( P = .043). The TFPI levels were higher in group 3 than in the other groups ( P < .001). There was a strong positive correlation between 25(OH)D3 and TFPI levels ( r = .47, P < .001). Conclusion: Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015
High plasma level of P-selectin is associated with the development of venous thromboembolism (VTE). Furthermore, supplementation of vitamin D could decrease thrombotic events. Hence, this study was designed to examine whether the administration of vitamin D can influence the plasma level of P-selectin in patients with VTE. In the randomized controlled trial, 60 patients with confirmed acute deep vein thrombosis and/or pulmonary embolism (PE) were randomized into the intervention (n = 20) and control (n = 40) groups. The intervention arm was given an intramuscular single dose of 300 000 IU vitamin D3. Plasma level of 25-hydroxy vitamin D, P-selectin, and high-sensitive C-reactive protein (hs-CRP) was measured at baseline and 4 weeks after. The plasma level of P-selectin (95% confidence interval = -5.99 to -1.63, P = .022) and hs-CRP (P = .024) significantly declined in vitamin D-treated group, while only hs-CRP was significantly decreased in the control group (P = .011). However, the...
Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults
PLOS ONE
Introduction Vitamin D insufficiency, defined as 25-hydroxyvitamin D (25(OH)D) levels < 75nmol/L is associated with cardio-metabolic dysfunction. Vitamin D insufficiency is associated with inflammation and fibrosis, but it remains uncertain whether these anomalies are readily reversible. Therefore, we aimed to determine the effects of vitamin D supplementation on markers of: 1) nitric oxide (NO) signaling, 2) inflammation, and 3) fibrosis, in healthy volunteers with mild hypovitaminosis. Methods Healthy volunteers (n = 35) (mean age: 45 ± 11 years) with 25(OH)D levels <75nmol/L, received vitamin D supplementation (Ostelin ® capsules 2000IU) for 12 weeks. Resting systolic and diastolic blood pressures (BP) were assessed. Routine biochemistry was examined. Plasma concentrations of asymmetric dimethylarginine (ADMA), thrombospondin-1 (TSP-1), plasminogen activator inhibitor-1 (PAI-1), hs-CRP, activin-A, and follistatin-like 3 (FSTL3) were quantitated. Results Vitamin D administration for 12 weeks significantly increased 25-(OH)D levels (48.8 ± 16 nmol/L to 100.8 ± 23.7 nmol/L, p<0.001). There was significant lowering of systolic and diastolic BP, while there was no significant change in lipid profiles, or fasting insulin. Plasma concentrations of ADMA, hs-CRP, PAI-1, activin A, and FSTL-3 did not change with vitamin D supplementation. However, there was a marked reduction of TSP-1 (522.7 ± 379.8 ng/mL vs 206.7 ± 204.5 ng/mL, p<0.001).
Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke
International journal of cardiology, 2017
There continues to be interest in understanding the role of vitamin D in the pathogenesis, epidemiology and prevention of cardiovascular disease (CVD). In fact vitamin D deficiency has been associated to an increased risk of developing CVD given to the relationship between low vitamin D levels and obesity, diabetes mellitus, dyslipidaemia, endothelial dysfunction and hypertension. However, although vitamin D has been identified as a potentially important marker of CVD, the mechanisms through which vitamin D deficiency leads from endothelial dysfunction to myocardial infarction and stroke are not fully understood. Thus, the goal of this review is to provide an updated review of the literature on the basic science of how vitamin D may affect the cardiovascular system and in particular to analyze the role that vitamin D may have in the whole dynamic process from the initiation of endothelial dysfunction to the development of myocardial infarction and stroke.
Relationship between vitamin D levels and platelet count: A retrospective study
Gulhane Medical Journal, 2020
Vitamin D is synthesized from cholesterol and has hormonal activity. Vitamin D has some important metabolic effects such as regulation of calcium and phosphorus homeostasis, bone mineralization, enhancing immune system, regulating cell division and differentiation, regulating coagulation and decreasing inflammation. Vitamin D enhances calcium absorption in the duodenum and reduces calcium excretion by the kidney (9). Low vitamin D levels were associated with coronary heart disease, metabolic syndrome, insulin resistance, susceptibility to infections, allergic diseases, malignancies and autoimmune diseases (10).
Impact of vitamin D on cardiovascular disease - mini review
Cab Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 2016
Vitamin D deficiency was only limited to rickets in children and bone related disorders in adults in the past. However, nowadays it has also been associated with the pathogenesis and/or progression of many other diseases such as hypertension, multiple sclerosis (MS), diabetes, cancer, and renal disease. Despite this close relationship of vitamin D deficiency with human diseases, vitamin D insufficiency is not widely recognized as a problem by people, especially patients and physicians as well as health policy makers. It is recommended to conduct further studies on this association to clarify the exact effect of vitamin D deficiency as well as supplement therapy with vitamin D on human diseases.