The effectiveness of clomiphene citrate in LH surge suppression in women undergoing IUI: a randomized controlled trial (original) (raw)

2010, Fertility and Sterility

Objective: To study the effectiveness of clomiphene citrate (CC) in preventing a premature LH surge during controlled ovarian stimulation in women undergoing assisted reproduction. Design: Prospective, randomized, controlled trial. Setting: University hospital. Patient(s): Two-hundred thirty couples with mild male factor, or unexplained infertility. Intervention(s): Couples were randomized to receive human menopausal gonadotrophins (hMG) followed by CC or hMG alone until the day of hCG. Main Outcome Measure(s): The primary outcomes were the incidence of a clinical pregnancy and premature LH rise. Secondary outcomes were the E 2 levels, number of mature follicles, and endometrial thickness as determined on the day of hCG. Result(s): The number of patients who had a premature LH surge was significantly lower in the hMG þ CC group (5.45% vs. 15.89%). Additionally, the mean E 2 levels (pg/mL) and the number of mature follicles were also significantly higher in the hMG þ CC group (360.3 AE 162.9 vs. 280 AE 110.0 and 2.4 AE 0.97 vs. 1.3 AE 1.1, respectively), although there was no significant difference regarding number of canceled cycles, endometrial thickness, or clinical pregnancy rate. Conclusion(s): The addition of CC to hMG has been proven to be effective in reducing premature LH surges without compromising the pregnancy rate. (Fertil Steril Ò 2010;94:2167-71. Ó2010 by American Society for Reproductive Medicine.

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