Anticancer Activity of Natural Bioactive Compounds against Human Carcinoma Cell Lines - A mini review (original) (raw)
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Cancer is a complex disease which is associated with cell signaling, DNA damage and cell cycle. Cancer is a multifactorial in origin .Cancer causes for 12.5% of deaths worldwide. Cancer treatment methods in cancer therapy like radiation and chemotherapy and using synthetic drugs leading to side effects. Therefore, there is a lot of demand to identify and develop effective novel therapeutic agents to treat many diseases. Plants are richest and unique source of energy, oxygen, metabolites and therapeutic agents. Many compounds of plant derivatives are very active against many dreadful diseases including cancer. Humans benefit from using many of the plants as medicinal purposes to combat diseases and microbes. Since plants are the natural, safe and best source in providing these active components especially anticancer drugs. Hence it is very essential to study about natural products and their potential role in therapeutic use. This review paper focuses mainly on achievements in cancer therapy using plant products and the potential clinical applications of medicinal plants and the role of their products, especially as anticancer drugs.
Anticancer Potential of Plants and Natural Products: A Review
American Journal of Pharmacological Sciences, 2013
Cancer is one of the leading causes of death and globally the numbers of cases of cancer are increasing gradually. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. The major problem in the cancer chemotherapy is the toxicity of the established drugs. However plants and plant derived products have proved effective and safe in the treatment and management of cancers. These days most of the research work on cancer drugs is targeted on plants and plants derived natural products. Many natural products and their analogues have been identified as potent anti-cancer agents and day by day the anti-cancer property of various plants is being identified. Here an attempt is being made through this review to highlights the natural products and their analogues established as anti-cancer agents and the new plant species identified with anti-cancer properties either in vivo or in vitro.
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Cancer is a major public health burden in both developed and developing countries and globally the numbers of cancer patients are increasing day by day. There are several medicines available in the market to treat the various types of cancer but no drug is found to be fully effective and safe. So the anticancer activity of certain natural products and their analogs are being explored. Diverse efficient compounds derived from natural products have been isolated as anticancer agents. These chemical compounds are formulated with a view to create effective drugs against cancer. This review focuses on some medicinal plants used for treating cancer. The phytochemical exploration of these plants will make significant contribution to the discovery of new anticancer drugs. In recent years, owing to the fear of side effects, people prefer to use natural plant products for cancer treatment. Although drug discovery from medicinal plants continues to provide an important source of safe drugs, numerous challenges are encountered including the procurement of plant materials and their selection. This paper reviews wide array of promising bioactive compounds obtained from various medicinal plants and their potential therapeutic uses.
Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment
Pharmaceuticals, 2021
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless,...
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Chinese Journal of Natural Medicines, 2014
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Medicinal Plants as Potential Source of Anticancer Agents: A Review
Journal of Pharmacognosy and Phytochemistry, 2016
Cancer is a major public health burden in both developed and developing countries. Anticancer activity is the effect of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Therefore an attempt has been made to review some medicinal plants having anticancer properties. In this review, anticancer medicinal plants of Indian origin belonging to various families are reported along with detailed information. All these plants are potential candidates for advanced studies since they are showing good anticancer activity. The present paper is a comprehensive review of different literature sources. It will be helpful to explore the medicinal value of the plants against the cancer and for the new drug discovery from them for the researchers and scientists around the world.
Plants and its parts as a source of anti-cancer compounds: A review
Plant has been used in the treatments of many diseases and now it has shown tremendous potential in the treatment of cancer. Various parts of plant including whole plant, leaves, bark, roots and fruits yield compounds which show greater prospective of treating cancer cells in the biological system. This review gives an insight about the anti-cancer compounds isolated from plants and its parts. The compounds described consist of marketed drugs, drugs under clinical trials, and herbs which have been not tested on human models. This review also illustrates that which drug is effective against the type of cancer. The review concludes with the future prospects of these compounds which could be marketed for the better health of the patients.
An overview of medicinal plants as anticancer agents
IP International Journal of Comprehensive and Advanced Pharmacology, 2021
Due to the lack of conventional therapies and the severe side effects of chemotherapy, cancer is a major public health concern across the world. After cardiac disorder, it is the second leading cause of death globally. Since ancient times, medicinal plants have been utilized to cure a variety of diseases. Natural products play an essential role in the battle against cancer and serve as a useful access source for the development and testing of novel therapeutic agents. The discovery and development of anticancer drugs can be aided by medicinal plants which contain various bioactive secondary phytochemicals viz. Alkaloids, phenolics, flavonoids, carotenoids, and other secondary metabolites. The therapeutic plants and their bioactive constituents exerted anticancer effects by induction of apoptosis, removing free radicals and antioxidant effects, inhibition of angiogenesis, and cell cycle arrest. This review explains an overview of potential therapeutic plants, including a brief descri...
ANTI-CANCER AGENTS DERIVED FROM PLANT AND DIETARY SOURCES: A REVIEW
Cancer is a disease of deregulated cellular behavior. Acquisition of oncogenic attributes, loss of tumor suppressive functions, evasion of physiological tissue architecture and interactions with the cellular microenvironment enable malignant cells to escape the mechanisms of normal cellular homeostasis in an organism. Cancer cells are therefore able to sustain unlimited proliferation, to thrive under conditions that preclude normal cell survival, and to spread to distant sites through the process of metastasis. Natural products are important sources of new anticancer drugs, new drug leads and new chemical entities. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, paclitaxel, etoposide, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide (allium), S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin (fenugreek), 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears, prunes), silymarin (milk thistle), anethol (anise, camphor, and fennel), catechins (green tea), eugenol (cloves), indole-3-carbinol (cruciferous vegetables), limonene (citrus fruits), beta carotene (carrots), and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents, but also novel lead compound and potentially relevant mechanisms of action.
Anti-Cancer Constituents from Plants: A Brief Review
2020
Now-a-days, cancer is a major concern globally, for which a large number of deaths occur annually, instead of the accessibility to various treatment options. Nevertheless, the latest treatment options are principally conglomerate with many side effects. Consequently, the development of an effective and competent anticancer therapy with the lower or minimum adverse or unwanted minor effect is the prime direction of research in the fields of natural product chemistry, drug design, and drug discovery. Phytochemicals available in plants have already been proven as prospective candidates in this regard. In general, phytochemicals are non-selective in their functions and restricted due to their differential activity on cancer cells along with the normal cells. As a consequence, researchers show their interest in isolating bioactive phytochemicals from nature with potent anticancer properties and generate lead compounds based on the natural skeleton of a molecule as a synthetic approach. S...