Role of glucocorticoid receptor in vision and behavior (original) (raw)

Neuroscience Research, 2007

Abstract

Concomitant activation of ACC and DLPFC has been linked to cuereactivity, but their differences are not known. We studied the role of DLPFC using rTMS that reduces excitability of the targeted cortex. Ten smokers received four fMRI scans on different days, during which they viewed smoking-cue video. Each of four fMRI was scanned under different conditions of expectancy (non-expectant vs. expectant) and rTMS (true vs. sham) performed immediately before scan. Repeated TMS was targeted previously identified left DLPFC. In the true TMS condition, we found lowered self-reporting cue-induced craving and lack of cue-induced BOLD increase in the ACC and a correlation between craving and BOLD signal in the left DLPFC, both observed during the expectant and the sham rTMS conditions. The left DLPFC became less responsive to input from the contralateral DLPFC and medial temporal regions, but not to ACC. These findings suggest that DLPFC associates perceived drug availability with craving in a positive feed-forward manner.

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