Development of EEG test for psychiatric disorder Schizoprenia (original) (raw)

Schizophrenia is a long-term mental illness affecting ~1% of the population. Patients exhibit symptoms such as hallucinations, delusions, emotional flattening, as well as functional deficits. Structural and functional alterations in the prefrontal cortex and abnormalities in other brain regions have been reported. Early diagnosis of Schizophrenia is challenging and there are few appropriate biomarkers to study associated brain abnormalities. Deficits in mismatch negativity (MMN), an electroencephalography (EEG) measure to distinguish rare deviant auditory stimuli, are specific to Schizophrenia, and associated with functional and cognitive disability. The MMN amplitude is reduced compared to healthy controls. Reduced auditory P300 amplitude also reflects deficits in cognitive processing in Schizophrenia. This project measured five deviant MMNs and P300 in 13 healthy male controls and investigated increased inter-stimulus interval (ISI), allowing more data to be included in a novel frequency analysis. Time domain analysis was performed on raw and filtered data while time/frequency analysis was performed on MMN and P300 raw data in one of