Diagnostic reliability check of red cell indices in differentiating Iron Deficiency Anemia (IDA) from Beta Thalassemia Minor (BTT) (original) (raw)
2016, Bimonthly Journal of Hormozgan University of Medical Sciences
Abstract
Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study. Correspondence: Mostafa Ravanbakhsh, MD. Department of Pathology, Hazrat-E- Abolfazl Hospital, Hormozgan University of Medical Sciences. Minab, Iran Tel:+98 9177675403 Email: mostafaravanbakhsh1358@gmail.com Methods: A total of 227 patients from 21st March to 21st June 2014 were studied by calculating 14 DFs i.e. Keikhaei (KI), RDWI, Green & King (G & KI), England & Fraser (E & FI), Mentzer (MI), Shine & Lal (S & LI), Telmissani (TI), Ricerca (RI), Ehsani (EI), Keli (RBC) and 4 new indices (F1, F2, F3 & F4). The study included 105 iron deficient patient and 122 beta-thalassemia trait cases (HbA2>3.5 & HbA2 KI> RDWI> E & FI> F3> EI> MI> RBC>...
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.
References (23)
- Ehsani MA SE, Shahgholi E, Rahiminejad MS, Seighali F, Rashidi A. A new index for discrimination between Iron deficiency anemia and Beta -Thalassemia minor: Results in 284 patients. Pakistan Journal of Biological Sciences. 2009;12(5):473-475.
- Merat A, Haghshenas M. The spectrum of betathalassemia mutations in Iran. Med J I R Iran. 2000;14(1):103-106.
- Keikhaei B, Zandian K, Ghasemi A, Tabibi R. Iron-deficiency anemia among children in southwest Iran. Food and Nutr Bull. 2007;28(4):406-411.
- Hashemizadeh H, Noori R. Premarital Screening of Beta Thalassemia Minor in north-east of Iran. Iran J Ped Hematol Oncol. 2013;3(1):210-215.
- Keikhaei B. A new valid formula in differentiating Iron deficiency anemia from β- Thalassemia trait. Pak J Med Sci. 2010;26(2):368-373.
- Alwar V, Kavdia R, Singh N, Rameshkumar K. Hunt for hidden trait. J Lab Physicians. 2009;1(1):15-18.
- Shalev O, Yehezkel E, Rachmilewitz EA. Inadequate utilization of routine electronic RBC counts to identify Beta Thalassemia carriers. Am J public Health. 1988;78(11):1476-1477.
- Nobilia B, Perrotta S, Matarese MR, Conte ML, del Giudice EM. Evaluation of body iron status in Italian carriers of beta-thalassemia trait. Nutrition Research. 2001;21(1-2):55-60.
- Madan N, Sikka M, Sharma S, Rusia U. Phenotypic expression of Hemoglobin A2 in betathalassemia trait with iron deficiency. Ann Hematol. 1998;77(3):93-96.
- Youde WJ. Index for rating diagnostic tests. Cancer. 1950;3(1):32-35.
- Jayabose S, Giamelli J, Levondoglu Tugal O, Sandoval C, Ozkaynak F, Visintainer P. Differentiating iron deficiency anemia from thalassemia minor by using an RDW-based index. J Pediatr Hematol Onclo. 1999;21(4):314.
- Green R, King R. A new red blood cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells. 1989;15(3):481- 491.
- England JM, Fraser PM. Differentiation of iron deficiency from thalassemia trait by routine blood-count. The Lancet. 1973;3:1(7801):449- 452.
- Mentzer WC JR. Differentiation of iron deficiency from thalassemia trait. Lancet. 1973;1(7808):882.
- Shine I, Lal S. A strategy to detect beta thalassemia minor. Lancet. 1977;1(8013):692- 694.
- Telmissani OA KS, Roberts GT. Mean density of hemoglobin per liter of blood: a new hematologic parameter with an inherent discriminant function. Lab Haematol. 1999;5(1):149-152.
- Ricerca BM SS, Storti S, d'Onofrio G, Mancini S, Vittori M, Campisi S, et al. Differentiation of iron deficiency from thalassemia trait: A new approach. Haematologica. 1987;72(5):409-413.
- Rathod DA, Kaur A, Patel V, Patel K, Kabrawala R, Patel V, et al. Usefulness of cell counter-based parameters and formulas in detection of beta-thalassemia trait in areas of high prevalence. Am J Clin Pathol. 2007;128(4):585-589.
- Rahim F, Keikhaei B. Better differential diagnosis of Iron deficiency anemia from beta-thalassemia trait. Turk J Hematol. 2009;26(3):138-145.
- Ntaios G, Chatzinikolaou A, Saouli Z, Girtovitis F, Tsapanidou M, Kaiafa G, et al. Discrimination indices as screening tests for â- thalassemic trait. Ann Hematol. 2007;86(7):487- 491.
- Alfadhli SM, Al-Awadhi AM, Alkhaldi AD. Validity assessment of nine discriminant functions used for the differentiation between iron deficiency anemia and thalassemia minor. J Trop Pediatr. 2007;53(2):93-97.
- Rosatelli C, Leoni GB, Tuveri T, Scalas MT, Mosca A, Galanello R, et al. Heterozygous beta-thalassemia; relationship between the hematological phenotype and the type of beta -thalassemia mutation. Am J Hematol. 1992;39(1):1-4.
- Rajabiani A. Heshmati P, Ghafouri M. Mean Density of hemoglobin a better discriminator of Iron deficiency anemia from Thalassemia minor. MJIRC. 2005;8(2):47-50.