The method of extracorporeal resection of the kidney in conditions of pharmaco-cold ischemia in kidney cancer with orthotopic renal replantation (original) (raw)
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Kidney cancer is a common cause of death for many patients worldwide.The exact cause of kidney cancer is unknown. Factors that increase the risk of developing kidney cancer are: old age, chronic kidney failure, dialysis, polycystic kidney disease, kidney stones, etc. It’s targeting and elimination is still a problem in modern medicine. Chemotherapy, radiation, surgery, and immunotherapy ас standard treatments for this type of cancer do not give satisfactory results. One of the newer approaches in the treatment of kidney cancer is the use of tyrosine kinase inhibitors (sunitinib or pazopanib) that inhibit angiogenesis by preventing the growth, development and metastasis of cancer. Both medicines have inhibitory effects against vascular endothelial growth factor (VEGF) and inhibit its biological activities (blood vessel formation, cancer progression). More specifically, these drugs are tyrosine kinase inhibitors and inhibit the biochemical pathways that take place inside the cell when...
Ukrainian Journal of Nephrology and Dialysis
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Novosti Khirurgii, 2014
Институт общей патологии и патологической анатомии, Клиника "rechts der Isar" Технического Университета Мюнхена 3 , г. Мюнхен, Институт судебной медицины Людвиг-Максимиллиана и Технического Университета Мюнхена 4 , г. Мюнхен, Клиника Св. Марии, Академическая учебная клиника университета Ганновера, г. Фехта 5 , Федеративная Республика Германия Пересадка почки является рутинным вмешательством в современной трансплантологии, спасающим десятки тысяч жизней по всему миру ежегодно. Эта методика прошла долгий путь развития, прежде чем достичь современного состояния. У истоков трансплантации почки стояли такие всемирно известные ученые-хирурги как Carrel, Landsteiner, Hufnagel и Murray. Почетное место среди них принадлежит украинскому хирургу Юрию Вороному, впервые в мире выполнившему эксплантацию почки у трупного донора, а также ее аллотрансплантацию у пациента в клинике. Наиболее удивительным при этом является то, что данный факт еще до недавнего времени был недостаточно известен широкой мировой медицинской общественности. В настоящей статье мы поставили перед собой цель провести обзор архивной литературы о Юрии Вороном и предоставить новый, незаангажированный взгляд на биографию этого выдающегося хирурга и ученого. Мы также попытались описать и проанализировать выполненную Ю. Вороным в 1933 году первую клиническую эксплантацию и аллотрансплантацию почки у человека. Кроме того, целью работы был ретроспективный анализ результатов выполненных им клинических трансплантаций почек и их современная оценка с точки зрения ценности для развития транспланталогии. Мы также попытались провести обзор научных исследований ученого в других областях хирургии. Юрий Вороной был неординарной личностью, хирургом и ученым, который, несмотря на все неблагоприятные политические и социальные обстоятельства, волею судьбы и силой собственного характера стал пионером мировой трансплантации почки. Результаты выполненных им клинических трансплантаций были важным источником первичных знаний, позволивших развивать данную методику хирургам западных стран. Каждый пациент с пересаженной почкой, по сути, в какой-то мере обязан своей жизнью Юрию Вороному. Ключевые слова: история медицины, история трансплантологии, трансплантация почки, Ю.Ю. Вороной Kidney transplants are one of the most common transplant operations in the modern transplantology saving annually tens of thousands of lives worldwide. This technique has come a long way of development before reaching the current state. Such world famous scientists and surgeons as Carrel, Landsteiner, Hufnagel and Murray were pioneers of the kidney transplantation. The honorable place among them belongs also to the Ukrainian surgeon Yury Voronoy who performed the first human-to-human renal transplant using cadaver organ. Astonishing is that until recently this fact hasn't been known to the world medical community. In the present paper we aim to review the archival literature about Yury Voronoy and present a new independent view at the biography of this prominent surgeon and scientist. We have also tried to describe and analyze the first in the world clinical kidney explantation and allotransplatation to human carried out in 1933 by Voronoy. In addition we had the goal to perform a retrospective analysis of the results of all the kidney transplantations that he performed and evaluate them in respect on their importance for the development of the transplantology. We have also tried to review the researches of this scientist in the other branches of surgery. Yury Voronoy was not an ordinary person, surgeon and scientist who, despite all the unfavorable political and social circumstances of his time by fate and thanks to the force of his own character, became a pioneer of the world kidney transplantation. The results of the clinical transplantations performed by Yury Voronoy were an important source of the primary knowledge that allowed developing this method for the surgeons of the western countries. Every patient with the transplanted kidney, as a matter of fact, to a certain extent is obliged by his life to Yury Voronoy.
Russian Journal of Transplantology and Artificial Organs, 2018
Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation.
The Use of Extracorporeal Liver Support Systems In Acute Decompensated Liver Failure
General Reanimatology
The aim of the study: to evaluate the efficacy of extracorporeal liver support systems in patients with acute liver failure of various etiologies.Material and methods. The study included 117 patients with acute liver failure of various etiologies. The main group consisted of 71 patients who received complex intensive therapy, including MARS-therapy and hemodiafiltration. The comparison group included 46 patients who received albumin dialysis (24 patients) and hemodiafiltration (22 patients) alone. The mean age of the patients was 34±5.6 years, the majority (56.4%) were men. Dynamic assessment of patients' severity was performed using Sequential Organ Failure Assessment (SOFA) and Model for End-Stage Liver Disease (MELD) scales.Results. A more significant reduction of SOFA and MELD scores was noted as early as by day 10 of intensive therapy in the main group with sequential use of extracorporeal liver detoxification methods — to 2.7±0.2 vs. 8.3±0.5 points (P=0.021) on SOFA and to 16.7±...