A New Method to Estimate Inhibition Percentage of Endogenous Digitalis in Patients with Pre-eclampsia (original) (raw)
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International Journal of Molecular Sciences
Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is the major cause of morbidity and mortality linked to pregnancy, affecting both mother and fetus. Despite advances in prophylaxis and managing PE, delivery of the fetus remains the only causative treatment available. Focus on complex pathophysiology brought the potential for new treatment options, and more conservative options allowing reduction of feto-maternal complications and sequelae are being investigated. Endogenous digitalis-like factors, which have been linked to the pathogenesis of preeclampsia since the mid-1980s, have been shown to play a role in the pathogenesis of various cardiovascular diseases, including congestive heart failure and chronic renal disease. Elevated levels of EDLF have been described in pregnancy complicated by hypertensive disorders and are currently being investigated as a therapeutic target in the context of a possible breakthrough in managing preeclampsia. Thi...
Study of changes in biochemical parameters of preeclampsia patients, a prospective five year study
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Preeclampsia is associated with changes in biochemical parameters like hepatic dysfunction, increase in blood glucose, thrombocytopenia, urea, creatinine, uric acid, alteration in lipid profile, hypoalbuminemia, electrolyte and C-reactive protein. Based on variability in literature regarding biochemical parameters present study has been designed to evaluate the changes in biochemical parameters in preeclampsia patients in tertiary care hospital.Methods: Pregnant women with pre eclampsia attending OPD of obstetrics department were enrolled for this study based on following inclusion and exclusion criteria. Similarly normotensive pregnant women were enrolled as control per same inclusion and exclusion criteria.Results: Total platelet count was significantly lower in preeclampsia patients then control (2.02±0.7 lakh/µl versus 3.29±.58 lakh/µl). Blood urea was significantly higher in preeclampsia patients than control (29.22±4.56 mg/dl versus 18.32±6.23 mg/dl), (p=0.0001) se...
Cogent Medicine, 2017
Background: Preeclampsia remains a poorly understood complication of pregnancy affecting 5-14% pregnancies worldwide. Recent studies indicate that serum electrolytes may play a role in preeclampsia since it is a vascular endothelial disorder. Aim: To compare serum sodium and potassium levels between preeclamptics and normotensive pregnant women in a tertiary hospital in Ghana. Methods and materials: This was a case-control study consisting of 30 preeclamptics and 30 normotensive pregnant women recruited consecutively at their first third trimester pre-natal visit at Korle-Bu Teaching Hospital. Serum sodium and potassium were analysed using Sherwood Flame Photometer (Model 420 Sherwood Scientific Ltd, UK). Analysis was done using Statistical Package for Social Sciences (SPSS®) software version 20.0 and presented as means (standard deviation). A p-value of ≤0.05 was judged significant. Results: There was a significantly reduced (p < 0.001) serum sodium levels in preeclamptics (mean = 136.13; SD = 4.17 mmol/L) compared to normotensive pregnant women (mean = 142.17; SD = 5.66 mmol/L). There was a significantly reduced (p < 0.001) serum potassium levels in preeclamptics (mean = 3.45; SD = 0.54 mmol/L) compared to normotensive pregnant women (mean = 3.98; SD = 0.36 mmol/L). Conclusion: The reduced levels of serum sodium and potassium in preeclampsia as compared to normotensive pregnant women, suggests that changes in these electrolytes may be associated with preeclampsia.
Erythrocyte cation metabolism in preeclampsia
American Journal of Obstetrics and Gynecology, 1989
To determine if there are abnormalities in cellular cation regulation in pregnancy-induced hypertension, erythrocyte intracellular levels of calcium, magnesium, sodium, and potassium and circulating parathyroid hormone and "endoxin" were examined in 13 women with pregnancy-induced hypertension and 34 control subjects matched for gestational age (:235 weeks). Both endoxin and parathyroid hormone levels were higher in patients with pregnancy-induced hypertension than in control suojects (endoxin, 294 ± 34 vs. 210 ± 19 pg/ml, p < 0.05; parathyroid hormone, 0.65 ± 0.05 vs. 0.60 ± 0.03 ng/ml); the increase was significant only for endoxin. Intracellular calcium was higher in the patients with pregnancy-induced hypertension (0.033 ± 0.010 vs. 0.015 ± 0.001 mEq/L, p < 0.05, in the patients with pregnancy-induced hypertension and control patients, respectively) but intracellular sodium, potassium, and magnesium levels were not different. This intracellular calcium elevation may be caused directly by the increase in parathyroid hormone or indirectly by the observed elevation in endoxin. Our data indicate that the observed effect is specific because no changes in intracellular sodium, potassium, or magnesium levels were found.
Correlation between Serum Sodium and Potassium Levels in Preeclampsia
International Journal of Biochemistry Research & Review, 2020
Aims: The aim of this study was to find the correlation between serum sodium and serum potassium with preeclampsia. Study Design: This is a cross sectional study. Place and Duration of Study: Conducted in Department of Biochemistry in collaboration with the Department of Obstetrics and Gynaecology, (RIMS), Imphal (Manipur) from September 2016 to August 2018. Methodology: Blood samples of 30 diagnosed patients of preeclampsia and above 18 years of age admitted in the obstetrics antenatal ward of RIMS, Imphal was taken. Samples were analysed for serum sodium and potassium by randox rx imola autoanalyser. The data were analyzed using statistical tools like Chi-square test through SPSS 21.0. Results: Serum sodium levels were high in 63.34%of study group, low levels were seen in 3.33% followed by normal levels in 33.3%of study group. Serum potassium levels were low in 56.6%of study group, normal in 40% and high in 3.33% of study group. There was positive correlation between serum sodium ...
International Journal of Gynecology & Obstetrics, 2004
In contrast with advances made in treating or eliminating many other serious disorders, severe morbidity and mortality associated with pre-eclampsiayeclampsia remain among the leading problems that threaten safe motherhood, particularly in developing countries. This article reviews technical issues related to diagnosis, screening, prevention, and treatment of pre-eclampsia and identifies corresponding needs. The authors stress the lack of standardized definitions of pre-eclampsia and eclampsia and discuss problems in blood-pressure measurements and assessment of urinary protein. They summarize the evidence for prevention strategies and screening tests for early detection. For treatment, magnesium sulfate has been proven effective, but not widely used. The authors outline priorities for narrowing the identified gaps and emphasize the need for coordinated efforts to reduce the morbidity and mortality due to pre-eclampsiayeclampsia. They conclude that the mystery of this disease must be resolved to achieve primary prevention of it.
Diagnosis, pathophysiology and management of pre-eclampsia: a review
Portuguese Journal of Nephrology Hypertension, 2013
Pre-eclampsia is a multisystem disease that occurs in 2 to 8% of pregnant women and is a leading cause of maternal and perinatal morbidity and mortality. It is classically defined by new-onset hypertension and proteinuria after 20 weeks of gestation. In recent years, we have witnessed a substantial advance in the understanding of the pathogenesis of this condition. All disease subtypes are characterized by a disruption of vascular remodelling and a systemic antiangiogenic response that leads to hypertension, proteinuria, glomerular endotheliosis, HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome, and cerebral oedema-the clinical signs of pre-eclampsia and eclampsia. In the clinical practice, there is currently no reliable screening method in the first trimester of pregnancy with sufficient accuracy to identify women at high risk of developing pre-eclampsia, and only two interventions are strongly recommended by the World Health Organization for prevention of pre-eclampsia: calcium supplementation in all women with low dietary calcium intake and low-dose aspirin. Delivery is the only known cure. The treatment of pre-eclampsia and its complications is usually carried out by obstetricians but the role of nephrologists can be crucial, particularly when the condition is complicated by acute kidney injury. Several recent studies have shown an association between early-onset or severe pre-eclampsia and an increased risk of cardiovascular and/or renal disease later in life, suggesting that these women deserve a more careful monitoring programme, including clinical evaluation by nephrologists.
American journal of hypertension, 1995
An endogenous sodium pump inhibitor, or digitalis-like factor (DLF), has been postulated to mediate essential hypertension. It may also play a role in preeclampsia. However, studies of this factor in hypertensive pregnancy have not provided consistent findings. Part of this may be due to the absence of subclassification of pregnant women with pregnancy-induced hypertension (PIH) when assessing these parameters. In this study we explored serum DLF and digoxin-like immunoreactive factor (DLIF) in insulin-dependent diabetic (IDDM) women with normotensive pregnancies or PIH, comparing them to each other and to nondiabetic pregnant women. Our results demonstrated that nondiabetic women with preeclampsia (PE, PIH with proteinuria) had significantly increased serum DLF and DLIF compared to normotensive pregnant women (NL BP). Women with transient hypertension of pregnancy (THP, PIH without proteinuria) had intermediate values (DLF. NL BP: 3.3 +/- 0.6, THP: 4.8 +/- 1.1, PE: 7.6 +/- 1.3% inh...