Hemorheological Evaluation and Cytokine Production in Dogs Naturally Infected with Anaplasmataceae (original) (raw)
Related papers
Typical and Atypical Manifestations of Anaplasma phagocytophilum Infection in Dogs
Journal of the American Animal Hospital Association, 2011
Eighteen clinically ill dogs, naturally infected with Anaplasma phagocytophilum, were examined at a veterinary practice in Baxter, Minnesota. A clinical examination, complete blood cell count, enzyme- linked immunosorbent assay (ELISA) for A phagocytophilum, Borrelia burgdorferi, and Ehrlichia canis antibodies and Dirofilaria immitis antigen, and a polymerase chain reaction test for A phagocytophilum DNA were obtained for all dogs. Physical examination findings included fever, arthropathy, lymphadenopathy, epistaxis, acute gastritis, cervical hyperpathia, and central nervous system dysfunction. Complete blood cell count abnormalities included thrombocytopenia, morulae in neutrophils, anemia, leukopenia, eosinopenia, lymphopenia, and monocytosis. Seroreactivity to A phagocytophilum was found in 61%, B burgdorferi antibodies in 17%, and D immitis antigen in 5% of the dogs. Fever, arthropathy, neurologic dysfunction, and epistaxis are clinical syndromes that can be associated with A ph...
Exposure to Anaplasma phagocytophilum in two dogs in Belgium
Vlaams Diergeneeskundig Tijdschrift, 2015
In this report, two dogs are described, which were exposed to Anaplasma phagocytophilum in Belgium. The first case was presented for acute weakness and collapse, and was diagnosed with immune mediated hemolytic anemia. Vector-borne serology panel revealed a positive antibody titer for A. phagocytophilum, and the dog recovered during doxycycline therapy. The second patient suffered from an immune mediated glomerulopathy, and concurrently had a highly increased antibody titer for A. phagocytophilum. The relationship between canine granulocytic anaplasmosis and both IMHA and protein-losing nephropathy is unclear in these cases. However, it is suspected that A. phagocytophilum could be associated with kidney injury, as it is described in the second case.
Sri Lanka Vaterinary Journal, 2022
Canine anaplasmosis is a zoonotic disease caused by Anaplasma phagocytophilum and Anaplasma platys transmitted by ticks. In Sri Lanka, only a few studies are available as this disease is often neglected (underdiagnosed) in clinical practice due to the non-specific clinical signs. This clinical communication describes seroprevalence, clinical and laboratory findings of 266 dogs seropositive for Anaplasma spp. identified from 450 anaemic dogs presented from Gampaha, Colombo and Kalutara areas of Western Province, Sri Lanka. Accordingly, the seroprevalence of Anaplasma spp. among this population of anaemic dogs was 59% (266/450). The majority of the Anaplasma seropositive dogs had non-specific clinical signs with low packed cell volume and thrombocytopenia. There was no statistically significant difference between seropositivity with age or gender of the dogs.
Sensitivity and specificity levels of two rapid assays for antibodies to Anaplasma spp. in dogs
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 2017
Canine anaplasmosis is a tick-borne disease of dogs that results following infection with Anaplasma phagocytophilum or Anaplasma platys. The SNAP 4Dx Plus test (IDEXX Laboratories) and the VetScan Canine Anaplasma Rapid test (Abaxis) are commercial in-house rapid tests for the detection of antibody to these 2 antigenically related Anaplasma species. We evaluated 2 tests using serum and whole blood samples obtained from reference laboratories and veterinary hospitals. Samples were obtained from regions of the country known to be habitats of the primary tick vectors. The A. phagocytophilum sample set comprised 236 dog sera from the northeastern and midwestern United States; the A. platys sample set comprised 179 sera from dogs living in the southwestern United States. An indirect immunofluorescent antibody (IFA) test and an A. platys species-specific ELISA were used as reference assays for the A. phagocytophilum and A. platys samples, respectively. The SNAP test demonstrated significa...
Survey of Anaplasma phagocytophilum antibodies in dogs from South Western Romania
Current Opinion in Biotechnology, 2013
Anaplasma phagocytophilum (formerly Ehrlichia equi) is a tickborne pathogen of domestic horses and the causative agent of equine granulocytic anaplasmosis. After the occurrence of clinical anaplasmosis in a Przewalski's horse (Equus ferus przewalskii) housed at the Smithsonian Conservation Biology Institute in 2008, opportunistic serosurveillance of the herd was initiated. From 2008 to 2014, 57 serum samples were collected from 27 individuals (10 males; 17 females). Using indirect immunofluorescent antibody assays for anti-Anaplasma phagocytophilum antibodies, it was determined that prevalence was 53%. No significant sex differences were identified. A statistical association between increasing age and seropositive status suggests cumulative risk of exposure to Anaplasma phagocytophilum. After exclusion of four clinical cases of anaplasmosis, it was found that 22-57% of those sampled each year were seropositive and clinically normal, suggesting that the majority of Przewalski's horses develop subclinical or self-limiting anaplasmosis after exposure to A. phagocytophilum.