Klebsiella pneumoniae producing Carbapenemase KPC-3 identified in hospital wards (original) (raw)

Abstract

The emergence and global spread of Enterobacteriaceae carbapenem-resistant is a public health threat because they are associated with high morbidity and mortality. The aim of this study was to characterize the blaKPC-3 gene, their genetic environment and other resistances associated in bacteria with reduced susceptibility to carbapenems in the North of Lisbon Hospital Centre, EPE. Forty-one clinical isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter aerogenes, Escherichia coli and Citrobacter freundii were identified between November 2009 and June 2011 and all isolates were KPC-3 carbapenemase producing. Associated with this carbapenemase we detected other ß-lactamases: broad spectrum ß-lactamases, TEM-1 and SHV-1; extended-spectrum ß-lactamases SHV-12, SHV-35, CTX-M-15 and DHA-1 cefalosporinase. The absence of OmpK35 and OmpK36 outer membrane porins justify the increased of resistance in the strains to carbapenems and cephalosporins. The gene blaKPC-3 is associated...

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